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公开(公告)号：US12293827B2
公开(公告)日：2025-05-06
申请号：US17365464
申请日：2021-07-01
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stephen Martin , Jakub Winiarz , Alexandra Paun
Abstract: A computer-implemented method for inferring a condition of at least one analytical device based on at least one automatic notification received over a network from the analytical device is disclosed. The method comprises receiving, at a data processing agent, at least one automatic notification from at least one analytical device, processing, at the data processing agent, the at least one automatic notification, to thus identify one or more characteristics of the at least one automatic notification from the at least one analytical device, inferring, at the data processing agent, the condition of the at least one analytical device, by applying the one or more identified characteristics to a model; and generating, at the data processing agent, a notification reporting the inferred condition of the analytical device.
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公开(公告)号：US12275778B2
公开(公告)日：2025-04-15
申请号：US17015662
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to improved variant monoclonal antibodies binding to cardiac troponin T and having a better KD than the monoclonal antibody 12.1A11.11-7, produced by hybridoma clone 7.1 A 12.2-22 (ECACC 89060901) as deposited with European Collection of Animal Cell Cultures, GB.
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公开(公告)号：US12260956B2
公开(公告)日：2025-03-25
申请号：US18063836
申请日：2022-12-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Alejandro Morcillo Montejo , Raúl Ropero Ruíz
Abstract: A healthcare data management system for managing healthcare data comprising in-vitro diagnostics (IVD) data created using at least one IVD analytical instrument, the healthcare data management system being accessible by a plurality of client devices. The healthcare data management system including: a plurality of healthcare applications each configured to execute one or more operations associated with the healthcare data management system using healthcare data of the healthcare data management system; an intent management system including: an intent registry, storing information about a plurality of intents, the information for each intent including: an intent type identifier, and one or more healthcare applications configured to execute an operation associated with the intent type; and the intent management system further comprising: a healthcare application determination module configured to receive an intent, and to determine, using the intent registry, one or more healthcare applications configured to execute an operation associated with the received intent.
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公开(公告)号：US20250069875A1
公开(公告)日：2025-02-27
申请号：US18719252
申请日：2022-12-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Florian Schweinberger , Benjamin Tiemann , Marius Wagner
IPC: H01J49/00
Abstract: A method for characterization of a mass spectrometry instrument (100) comprising at least one mass analyzing cell (102, 104, 106) is proposed. The method comprising the steps of analyzing a sample (110) comprising at least one substance having a known molecular weight by means of the mass spectrometry instrument (100) so as to provide a mass spectrum (116, 118, 144, 146) of the sample (110), determining an outer envelope and an inner envelope of the mass spectrum (116, 118, 144, 146), calculating a squared difference between the outer envelope and the inner envelope, and determining a deviation of the calculated squared difference from a theoretical mass to charge ratio value of the substance.
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5.发明申请公开(公告)号：US20250067761A1
公开(公告)日：2025-02-27
申请号：US18941549
申请日：2024-11-08
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Ole Lambaek , Andreas Schesny
Abstract: The present disclosure refers to a method for operating a sorter device in an IVD laboratory system, the method comprising providing a sorter device in an IVD laboratory system provided with a system operation controller, the sorter device having a plurality of sample container racks each provided with reception holes for receiving sample containers, a handling device configured to pick sample containers from and place sample containers in the reception holes of the sample container racks, a sorter device controller configured to control operation of the sorter device and connectable to the system operation controller, and an output device functionally connected to the sorter device controller and configured to output at least one of audio data and video data. The sorter device is configured in a pre-operation process, the configuring comprising: assigning the plurality of sample container racks to a plurality of processing sub-targets conducted by the IVD laboratory system in operation, wherein a first sample container rack is assigned to a first processing sub-target and a second sample container rack is assigned to a second processing sub-target which is different from the first processing sub-target, and assigning to the first sample container rack a first threshold value indicative of a first threshold number of sample containers in the first sample container rack, wherein the first threshold number of sample containers is smaller than a maximum number of sample containers receivable in the first sample container rack. The sorter device is operated in an operation process, the operating comprising: placing sample containers in the reception holes of the first sample container rack by the handling device, determining a first present number of sample containers received in the first sample container rack by the sorter device controller, comparing the first present number of sample containers to the first threshold value by the sorter device controller, and if the first present number of sample containers is equal to or greater than the first threshold value, outputting a first warning data through the output device. Furthermore, an IVD laboratory system is provided.
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Patent Agency Ranking
公开(公告)号：US20250046455A1
公开(公告)日：2025-02-06
申请号：US18723851
申请日：2022-12-23
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Nils Bruenggel , Patrick Conway , Simon John Davidson , Emilie Dejean , Jacob Gildenblat , Chen Sagiv , Pascal Vallotton
Abstract: A computer-implemented method of differentiating between lymphoid blast cells and myeloid blast cells comprises: receiving a digital image containing one or more blast cells; applying a parametric model classifier to one or more portions of the digital image each containing a respective blast cell, the parametric model configured to generate an output indicative of whether each blast cell is a lymphoid blast cell or a myeloid blast cell. Computer-implemented methods of training a parametric model are also provided, as well as a clinical decision support system relying on the computer-implemented method of classifying blast cells.
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公开(公告)号：US12172299B2
公开(公告)日：2024-12-24
申请号：US17303373
申请日：2021-05-27
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Marius Kraetschmer , Andreas Decool
Abstract: A gripping system is provided comprising: gripping fingers of a first type, gripping fingers of a second type, a gripping device for handling sample containers, wherein the gripping device comprises base portions, wherein a gripping finger of the first type and a gripping finger of the second type are releasably fixable to the base portions, and a drive, wherein the drive is adapted to move at least one of the base portions relative to the other base portions to cause a gripping or a releasing of a sample container, and a gripping finger change device, wherein the gripping finger change device is adapted to store gripping fingers of the first type and gripping fingers of the second type, and wherein the gripping finger change device is adapted to replace a gripping finger of the first type fixed to a base portion by a gripping finger of the second type.
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公开(公告)号：US20240400672A1
公开(公告)日：2024-12-05
申请号：US18662694
申请日：2024-05-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Gerg , Klaus Hirzel , Caroline Dorothea Hojer , Hans-Peter Josel , Ute Jucknischke , Holger Lehmann , Anastasia Markina , Giuseppe Prencipe , Leopold von Proff , Michael Schraeml , Steinar Halldórsson
Abstract: The present invention provides a novel monoclonal antibody specifically binding to L-Thyroxine (T4) and compositions and kits comprising such antibodies. Furthermore, provided are polynucleotides encoding such monoclonal antibodies, host cells expressing said antibodies, methods of producing such antibodies and diagnostic methods using such monoclonal antibodies. The monoclonal antibody of the invention comprises a heavy chain variable domain (VH) comprising V or A in position 33; Y in position 50; W in position 52; I in position 98, G, A or V in position 99; Y in position 100; and I in position 100b; and a light chain variable domain (VL) comprising amino acids H or Y in position 28; N or K in position 29; W in position 32; G or A in position 91; Y, W or F in position 92; S or T in position 93; Y or F in position 95b; N, S, T or Q in position 95c; and H in position 96, wherein the positions of the amino acids in the VH and the VL are indicated according to the Kabat numbering scheme, respectively.
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公开(公告)号：USD1052269S1
公开(公告)日：2024-11-26
申请号：US29841723
申请日：2022-06-08
Applicant: Roche Diagnostics Operations, Inc.
Designer： Peter Arnold , Carolin Frontzek , Sofia Elisabeth Galbraith , Roman Gebhard
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公开(公告)号：US12152871B2
公开(公告)日：2024-11-26
申请号：US17110451
申请日：2020-12-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Rein
Abstract: A method for determining a vertical position of a horizontally extending interface between first and second components is presented. The first and second components are contained in a laboratory sample container in layers vertically separated from each other. The method comprises generating first data, generating second data in the form of picture data of the laboratory sample container containing the first and second components, determining a first probability distribution function in response to the first data, determining a second probability distribution function in response to the second data, and determining the vertical position of the horizontally extending interface depending on the first and second probability distribution functions. The first data depend on the vertical position of the horizontally extending interface. The first and second probability distribution functions assign a probability of the presence of the horizontally extending interface to a vertical position.
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