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    Mobile sensor system and methods for use
    2.
    发明授权
    Mobile sensor system and methods for use 有权

    公开(公告)号：US10729370B2

    公开(公告)日：2020-08-04

    申请号：US14964690

    申请日：2015-12-10

    申请人： Rosalind Franklin University of Medicine and Science

    发明人： Fang Lin ,  Sai V. Yalla

    IPC分类号： A61B5/00 ,  A61B3/113 ,  A61B5/11

    摘要： The present disclosure provides a system including one or more sensors, a mounting system configured to removeably mount a computing device such that a camera of the computing device is positioned facing an eye of a subject, and a control system. The control system is configured to (a) receive sensor data from the one or more sensors, (b) determine whether the sensor data is indicative of balance instability of the subject, (c) track a position of the eye of the subject to assess vestibular dysfunction, (d) determine whether the camera data is indicative of vestibular dysfunction of the subject, and (e) in response to (i) the sensor data being indicative of balance instability of the subject and/or (ii) the camera data being indicative of vestibular dysfunction of the subject, display an indication of symptoms that are characteristic of a traumatic brain injury or concussion.

    Antisense compounds targeting genes associated with usher syndrome
    5.
    发明授权
    Antisense compounds targeting genes associated with usher syndrome 有权
    靶向与引发综合征相关的基因的反义化合物

    公开(公告)号：US09353371B2

    公开(公告)日：2016-05-31

    申请号：US14009782

    申请日：2012-05-02

    申请人： Michelle L. Hastings ,  Frank Rigo ,  C. Frank Bennett

    发明人： Michelle L. Hastings ,  Frank Rigo ,  C. Frank Bennett

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  C07H21/04 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/33 ,  C12N2310/3525

    摘要： The present invention provides compounds comprising oligonucleotides complementary to an Usher transcript. Certain such compounds are useful for hybridizing to an Usher transcript, including but not limited, to an Usher transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the Usher transcript. In certain such embodiments, the Usher transcript includes a mutation that results in cryptic splicing and hybridization of the oligonucleotide results in a decrease in the amount of cryptic splicing. In certain embodiments, such compounds are used to treat Usher Syndrome.

    摘要翻译： 本发明提供了包含与Usher转录物互补的寡核苷酸的化合物。 某些这样的化合物可用于与Usher转录物杂交，包括但不限于细胞中的Usher转录物。 在某些实施方案中，这种杂交导致Usher转录物的剪接的调节。 在某些这样的实施方案中，Usher转录物包括导致隐含剪接的突变，并且寡核苷酸的杂交导致隐形剪接的量的减少。 在某些实施方案中，这些化合物用于治疗Usher综合征。

    Splice variant specific messenger RNA transcripts as biomarkers of parkinson's disease
    7.
    发明授权
    Splice variant specific messenger RNA transcripts as biomarkers of parkinson's disease 有权
    接头变体特异性信使RNA转录物作为帕金森病的生物标志物

    公开(公告)号：US08772468B2

    公开(公告)日：2014-07-08

    申请号：US13240821

    申请日：2011-09-22

    申请人： Judith A. Potashkin

    发明人： Judith A. Potashkin

    IPC分类号： C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention provides a method and a diagnostic kit for diagnosing the presence of Parkinson's disease in a human subject. The method includes the steps of: (1) extracting RNA molecules from a blood sample of the human subject to define a test sample; (2) measuring the amount of each RNA molecule having Sequence ID Nos. 1-14 in the test sample; (3) comparing the amount of each of the RNA molecules having Sequence ID Nos. 1-14 to the amount of RNA molecules having Sequence ID Nos. 1-14 present in a control sample to determine how many of the RNA molecules of Sequence ID Nos. 1-14 are present in a significant amount in the test sample greater or less than in the control sample to define a number of biomarkers; and (4) diagnosing the presence of Parkinson's disease in the human subject if the number of biomarkers is equal to or greater than five.

    摘要翻译： 本发明提供了用于诊断人类受试者中帕金森病存在的方法和诊断试剂盒。 该方法包括以下步骤：（1）从人受试者的血液样品中提取RNA分子以定义测试样品; （2）在测试样品中测量具有序列号1-14的每个RNA分子的量; （3）将具有序列号1-14的每个RNA分子的量与存在于对照样品中的具有序列号1-14的RNA分子的量进行比较，以确定序列ID的RNA分子中有多少 1-14在测试样品中大量存在或大于对照样品，以限定许多生物标志物; （4）如果生物标志物的数目等于或大于5，则诊断人类受试者中帕金森病的存在。

    METHOD AND KIT FOR MEASURING MICRO-RNA IN BODY FLUIDS
    8.
    发明申请
    METHOD AND KIT FOR MEASURING MICRO-RNA IN BODY FLUIDS 审中-公开
    用于测量体液中微RNA的方法和试剂盒

    公开(公告)号：US20140154685A1

    公开(公告)日：2014-06-05

    申请号：US13692477

    申请日：2012-12-03

    申请人： Rosalind Franklin University Of Medicine And Science

    发明人： Dominik M. DUELLI

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6806 ,  C12Q2525/207 ,  C12Q2527/125 ,  C12Q2527/137

    摘要： The present invention provides a kit for measuring the content of micro-RNA in a human blood sample including a blood collection tube containing at least 1 μg NaF and 0.8 μg KOx; and providing a set of instructions for collecting a human blood sample in the blood collection tube.

    摘要翻译： 本发明提供了一种用于测量人血液样品中微RNA含量的试剂盒，其包括含有至少1μgNaF和0.8μgKOx的采血管; 以及提供用于在采血管中收集人血液样本的一组说明书。