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    Methods for Sample Quality Assessment
    1.
    发明申请
    Methods for Sample Quality Assessment 有权

    公开(公告)号：US20210311071A1

    公开(公告)日：2021-10-07

    申请号：US17287959

    申请日：2019-10-28

    申请人： SOMALOGIC, INC.

    发明人： Dominic Anthony ZICHI ,  Matthew Joel WESTACOTT

    IPC分类号： G01N33/68

    摘要： The subject invention relates to methods for obtaining biological samples of improved quality. It encompasses the identification of markers or proteins in biological samples that are altered due to variations in sample collection, handling and processing. They are also useful for correcting variations in measured results for disease biomarkers. Further, they can permit the rejection of samples or groups of samples as necessary if it is determined that their collection method was not in accordance with the predetermined protocol. Other advantages useful to the skilled artisan are described herein.

    Multiplexed analyses of test samples
    6.
    发明授权
    Multiplexed analyses of test samples 有权
    测试样品的多重分析

    公开(公告)号：US09404919B2

    公开(公告)日：2016-08-02

    申请号：US14176933

    申请日：2014-02-10

    申请人： SomaLogic, Inc.

    发明人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Martin Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74

    CPC分类号： G01N33/5308 ,  G01N33/54306 ,  G01N33/6863 ,  G01N33/74

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

    摘要翻译： 本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。 所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。 所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。 本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。

    Multiplexed Analyses of Test Samples
    10.
    发明申请
    Multiplexed Analyses of Test Samples 有权
    测试样本的多路复用分析

    公开(公告)号：US20140249043A1

    公开(公告)日：2014-09-04

    申请号：US14176933

    申请日：2014-02-10

    申请人： SomaLogic, Inc.

    发明人： Daniel J. Schneider ,  Dan Nieuwlandt ,  Bruce Eaton ,  Martin Stanton ,  Shashi Gupta ,  Stephan Kraemer ,  Dominic Zichi ,  Larry Gold

    IPC分类号： G01N33/53 ,  G01N33/74 ,  G01N33/68 ,  G01N33/543

    CPC分类号： G01N33/5308 ,  G01N33/54306 ,  G01N33/6863 ,  G01N33/74

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

    摘要翻译： 本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。 所描述的方法，装置，试剂盒和试剂通过检测和定量核酸（即，适体）促进了测试样品中非核酸靶标（例如，蛋白质靶标）的检测和定量。 所描述的方法为非核酸靶产生了核酸替代物，从而允许将广泛种类的核酸技术（包括扩增）应用于更广泛的期望目标，特别是蛋白质靶标。 本公开进一步描述了适于在各种分析检测应用中促进适配体使用的适体构建体。