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公开(公告)号：US10724080B2
公开(公告)日：2020-07-28
申请号：US15937657
申请日：2018-03-27
申请人： SPEEDX PTY LTD
发明人： Alison Velyian Todd , Elisa Mokany , Samantha Walker , Cortny Donald , Dina Lonergan , Lit Yeen Tan
IPC分类号： C12Q1/68 , C12N15/113 , C12Q1/6858 , C12Q1/6818 , C12Q1/6853 , C12Q1/6848
摘要： The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.
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公开(公告)号：US09963738B2
公开(公告)日：2018-05-08
申请号：US14379178
申请日：2013-02-20
申请人： SpeeDx Pty Ltd
发明人： Alison Velyian Todd , Elisa Mokany , Samantha Walker , Cortny Donald , Dina Lonergan , Lit Yeen Tan
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6858 , C12N15/113 , C12N2310/12 , C12Q1/6818 , C12Q1/6848 , C12Q1/6853 , C12Q2525/161 , C12Q2535/125 , C12Q2537/159 , C12Q2521/345 , C12Q2535/131
摘要： The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.
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公开(公告)号：US20200299754A1
公开(公告)日：2020-09-24
申请号：US16472154
申请日：2018-04-11
申请人： SPEEDX PTY LTD
IPC分类号： C12Q1/6816 , C12Q1/44 , C12Q1/689
摘要： The present invention relates to compositions and methods for the detection of target molecules, and the amplification of detectable signals generated by detection assays. More specifically, the present invention relates to methods utilizing catalytic nucleic acid enzymes to generate and/or amplify a signal indicative of the presence of target molecules (e.g. nucleic acids and proteins), and compositions for use in the methods.
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公开(公告)号：US09725757B2
公开(公告)日：2017-08-08
申请号：US14409375
申请日：2013-06-18
申请人： SpeeDx Pty Ltd
IPC分类号： C12Q1/68 , C12N15/113 , C07H21/00 , C12P19/34 , C12N9/22
CPC分类号： C12Q1/6823 , C12N9/22 , C12Q1/682 , G01N2333/9005 , C12Q2521/337 , C12Q2521/345 , C12Q2525/205 , C12Q2537/163 , C12Q2565/1025
摘要： The present invention relates to compositions and methods for the detection of target molecules, and the amplification of detectable signals generated by detection assays. More specifically, the present invention relates to methods utilizing catalytic nucleic acid enzymes to generate and/or amplify a signal indicative of the presence of target molecules (e.g. nucleic acids and proteins), and compositions for use in the methods.
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5.发明授权公开(公告)号：US08673551B2
公开(公告)日：2014-03-18
申请号：US12094708
申请日：2006-12-07
申请人： Laurence Tatiana Rimsky , Inky Paul Madeleine De Baere , Bart Anna Julien Maes , Marie-Pierre T. M. M. G. De Bethune , Guenter Kraus , Elisa Mokany , Alison Velyian Todd
发明人： Laurence Tatiana Rimsky , Inky Paul Madeleine De Baere , Bart Anna Julien Maes , Marie-Pierre T. M. M. G. De Bethune , Guenter Kraus , Elisa Mokany , Alison Velyian Todd
CPC分类号： C12Q1/703
摘要： The present invention relates to methods and means for the evaluation of HIV replicative capacity in a given environment. In particular, the invention provides a growth competition assay that can determine relative viral fitness using a recombinant tagged HIV-1 virus system. The methods rely on plasmid vectors, amplicons, primers and probes, and the generation of replication-competent viruses therefrom. Said methods and materials may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
摘要翻译： 本发明涉及在给定环境中评估HIV复制能力的方法和手段。 特别地，本发明提供可以使用重组标记的HIV-1病毒系统确定相对病毒适应性的生长竞争测定。 该方法依赖于质粒载体，扩增子，引物和探针，并从中产生具有复制能力的病毒。 所述方法和材料可用于多个领域，包括诊断，药物筛选，药物遗传学和药物开发。
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公开(公告)号：US20140017669A1
公开(公告)日：2014-01-16
申请号：US13885554
申请日：2011-11-21
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , C12Q2521/337 , C12Q2537/162 , C12Q2565/101 , C12Q2521/301
摘要： The present invention relates to compositions and methods for the use of enzymes composed of nucleic acid and/or protein enzymes to generate and amplify a signal indicative of the presence of a target. More particularly, the invention relates to compositions comprising nucleic acid structures that serve as partial or complete enzyme substrates and methods for using these structures to facilitate detection of targets.
摘要翻译： 本发明涉及使用由核酸和/或蛋白质酶组成的酶来产生和扩增表示靶的存在的信号的组合物和方法。 更具体地，本发明涉及包含用作部分或完全酶底物的核酸结构的组合物以及使用这些结构以便于检测靶的方法。
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公开(公告)号：US09862990B2
公开(公告)日：2018-01-09
申请号：US13885554
申请日：2011-11-21
CPC分类号： C12Q1/682 , C12Q2521/337 , C12Q2537/162 , C12Q2565/101 , C12Q2521/301
摘要： The present invention relates to compositions and methods for the use of enzymes composed of nucleic acid and/or protein enzymes to generate and amplify a signal indicative of the presence of a target. More particularly, the invention relates to compositions comprising nucleic acid structures that serve as partial or complete enzyme substrates and methods for using these structures to facilitate detection of targets.
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公开(公告)号：US20160348161A1
公开(公告)日：2016-12-01
申请号：US14379178
申请日：2013-02-20
申请人： SpeeDx Pty Ltd
发明人： Alison Velyian Todd , Elisa Mokany , Samantha Walker , Cortny Donald , Dina Lonergan , Lit Yeen Tan
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6858 , C12N15/113 , C12N2310/12 , C12Q1/6818 , C12Q1/6848 , C12Q1/6853 , C12Q2525/161 , C12Q2535/125 , C12Q2537/159 , C12Q2521/345 , C12Q2535/131
摘要： The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.
摘要翻译： 本发明提供修饰的寡核苷酸及其用于检测核酸的方法。 寡核苷酸和方法在扩增和/或检测靶核酸序列遗传变异领域中具有特别的应用。
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公开(公告)号：US20150050656A1
公开(公告)日：2015-02-19
申请号：US14343840
申请日：2012-09-10
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12N15/111 , C12N2310/12 , C12N2310/53 , C12N2320/11 , C12Q1/6818 , C12Q1/686 , C12Q1/6865 , C12Q2521/345 , C12Q2522/101 , C12Q2565/1015
摘要： The invention relates to nucleic acid substrates for catalytic nucleic acid enzymes and methods utilising the substrates.
摘要翻译： 本发明涉及用于催化核酸酶的核酸底物和利用该底物的方法。
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公开(公告)号：US08394946B2
公开(公告)日：2013-03-12
申请号：US11544926
申请日：2006-10-06
CPC分类号： C07H21/04 , C12N15/111 , C12N2310/12 , C12N2320/10 , C12N2330/30 , C12Q1/6811 , C12Q1/6818 , C12Q1/682 , C12Q1/6823 , C12Q2537/125 , C12Q2525/161 , C12Q2521/337 , C12Q2525/205
摘要： The present invention relates to Multicomponent Nucleic Acid Enzymes (MNAzymes) and methods for their use. MNAzymes comprise two or more oligonucleotide components which self-assemble in the presence of one or more MNAzyme assembly facilitator molecules to form a catalytically active structure. Compositions for making MNAzymes, and collections of MNAzymes are provided. Also provided are methods for using MNAzymes for the detection, identification and/or quantification of one or more targets. The methods can be practiced in solution-based assays or in assays where one or more reaction components are attached to a support structure. The methods allow for multiplexing the MNAzyme detection to detect multiple targets in a single reaction. Also provided are kits for making the compositions, and for practicing the methods provided herein.
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