公开(公告)号：US12210014B2

公开(公告)日：2025-01-28

申请号：US17459158

申请日：2021-08-27

Applicant: SYSMEX CORPORATION

Inventor： Chikayuki Tsuruno ,  Takuya Kyoutou ,  Tadashi Ishimoto

IPC: G01N33/543

Abstract: Disclosed is a method for detecting a target substance, comprising: forming on a carrier a complex comprising Wisteria floribunda lectin (WFA) and a target substance by mixing the WFA immobilized on the carrier with the target substance comprising a sugar chain that binds to the WFA in the presence of an alcohol having 1 to 7 carbon atoms consisting of carbon atoms, hydrogen atoms, and oxygen atoms; and detecting the target substance by detecting the complex.

公开(公告)号：US20250027878A1

公开(公告)日：2025-01-23

申请号：US18766916

申请日：2024-07-09

Applicant: SYSMEX CORPORATION

Inventor： Hiroaki Matsuba

IPC: G01N21/64 ,  G01N33/50

Abstract: Disclosed is a method for analyzing blood cells. The method includes irradiating a measurement sample that contains particles stained with a fluorescent dye with at least one light, to acquire fluorescence information and scattered light information generated from the particle. The method includes classifying blood cells from the particles in the measurement sample, with reference to the fluorescence information and the scattered light information. The fluorescent dye including a halogen, an alkyl group, sulfo group, and/or a benzyl group.

公开(公告)号：US12175055B2

公开(公告)日：2024-12-24

申请号：US16583311

申请日：2019-09-26

Applicant: SYSMEX CORPORATION

Inventor： Kazuma Moriura ,  Hiroshi Kurono ,  Akihito Kato

IPC: G06F17/00 ,  G01N35/00 ,  G06F3/04817 ,  G06F3/0482 ,  G06F3/0484

Abstract: A display method according to one or more aspects may be a method used in a sample analyzer comprising holders configured to hold reagent containers of reagents used for an analysis of a sample. The display method may include: displaying, on a display unit, icons respectively associated with the holders; receiving selection of icons from the icons displayed on the display unit; and receiving an instruction for a predetermined operation relevant to the selected icons.

公开(公告)号：US20240329069A1

公开(公告)日：2024-10-03

申请号：US18616282

申请日：2024-03-26

Applicant: SYSMEX CORPORATION

Inventor： Masato HAYASHI ,  Rentaro TAKENAKA

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N2035/00752 ,  G01N2035/00801

Abstract: A sample measuring apparatus according to one or more embodiments is disclosed. The apparatus may include the sample rack storage in which the sample rack holding the sample container is installed, the reagent rack storage in which the reagent rack holding the reagent container is installed, an information reader, and a first flection unit. The sample rack storage is geometrically placed at a position farther from the information reader than the reagent rack storage. The information reader reads the sample identification information of the sample container from the first reflected light acquired via the first flection unit, and reads the reagent identification information of the reagent container from the second reflected light acquired not via the first flection unit.

公开(公告)号：US20240302398A1

公开(公告)日：2024-09-12

申请号：US18594881

申请日：2024-03-04

Applicant: Sysmex Corporation

Inventor： Noriyuki Nakanishi ,  Takaaki Nagai ,  Kota Misawa

IPC: G01N35/04 ,  G01N1/28

CPC classification number: G01N35/04 ,  G01N1/2813 ,  G01N2035/0415 ,  G01N2035/046

Abstract: Disclosed is a specimen analyzer that uses a specimen rack in which a plurality of specimen containers can be held to analyze a specimen in each of the specimen containers, and the specimen analyzer includes: a measurement unit configured to measure the specimen; and a transport unit comprising a first placement region which is disposed in front of the measurement unit and in which a plurality of the specimen racks can be placed, and a second placement region which is disposed in a left-right direction relative to the first placement region and in which a plurality of the specimen racks can be placed, the transport unit configured to transport the specimen racks placed in the first placement region and the second placement region to a start position at which the measurement unit starts measurement.

公开(公告)号：US12076724B2

公开(公告)日：2024-09-03

申请号：US16998040

申请日：2020-08-20

Applicant: SYSMEX CORPORATION

Inventor： Kazuhiro Yamada ,  Kazuki Asao ,  Keisuke Kuwano

IPC: B01L3/00 ,  B01L9/06 ,  G01N21/01 ,  G01N21/64 ,  G01N21/85 ,  G01N33/49

CPC classification number: B01L3/5085 ,  B01L9/06 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/85 ,  G01N33/4915 ,  B01L2200/025 ,  B01L2200/143 ,  B01L2300/0627 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636

Abstract: A specimen processing apparatus performs processing on a specimen contained in a container. The specimen processing apparatus includes: holders having different shapes, each of the holders being configured to hold the container; a holder placement unit that comprises holder receiving portions having different shapes, the shapes of the holder receiving portions corresponding to the shapes of the holders; and a specimen processing unit that performs processing on the specimen contained in the container held by one of the holders placed on the holder placement unit.

公开(公告)号：US12056869B2

公开(公告)日：2024-08-06

申请号：US17197123

申请日：2021-03-10

Applicant: SYSMEX CORPORATION

Inventor： Yoshinori Sasagawa ,  Yoshiaki Miyamoto ,  Kazumi Hakamada ,  Kengo Gotoh ,  Yosuke Sekiguchi

IPC: G06T7/00 ,  G06N3/08 ,  G06T7/11 ,  G06T7/187 ,  G06V20/69

CPC classification number: G06T7/0012 ,  G06N3/08 ,  G06T7/11 ,  G06T7/187 ,  G06V20/695 ,  G06T2207/10064 ,  G06T2207/20081 ,  G06T2207/30024

Abstract: An image analysis method according one or more embodiments may analyze a form of a cell using a deep learning algorithm with a structure of a neural network. The image analysis method may include: generating data for analysis from an image for analysis in which an analysis target cell is captured; inputting the data for analysis into the deep learning algorithm; and generating data indicating a form of the analysis target cell using the deep learning algorithm.

公开(公告)号：US12020492B2

公开(公告)日：2024-06-25

申请号：US17105047

申请日：2020-11-25

Applicant: SYSMEX CORPORATION

Inventor： Momoko Imakubo ,  Jianyin Lu ,  Kentaro Shirai ,  Eri Katsumata ,  Yuji Okamoto

IPC: G06V20/69 ,  G01N15/1429 ,  G01N15/1433 ,  G01N15/1434 ,  G06T7/00 ,  G06V10/70 ,  G01N15/00 ,  G01N15/10 ,  G01N15/14

CPC classification number: G06V20/69 ,  G01N15/1431 ,  G01N15/1433 ,  G01N15/1436 ,  G06T7/0012 ,  G06V10/87 ,  G01N2015/0019 ,  G01N2015/1028 ,  G01N2015/1495 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/20084 ,  G06T2207/30024

Abstract: The present invention is to facilitate analysis of a plurality of analysis items. A cell analysis method for analyzing cells is provided in which data for analysis of cells contained in a sample are generated, and an artificial intelligence algorithm to be the input destination of the generated analysis data is selected from among a plurality of artificial intelligence algorithms, data indicating the properties of the cells are generated based on the analysis data via the artificial intelligence algorithm.

公开(公告)号：US20240142789A1

公开(公告)日：2024-05-02

申请号：US18495946

申请日：2023-10-27

Applicant: SYSMEX CORPORATION

Inventor： Takuya KUWANA ,  Takeshi SUGIYAMA ,  Kazuhiro YAMADA ,  Ayato TAGAWA

IPC: G02B27/42 ,  G01N15/14

CPC classification number: G02B27/4205 ,  G01N15/1436 ,  G01N15/1459 ,  G01N2015/0065

Abstract: Disclosed is an optical system including: a light source configured to emit light; an irradiation optical system including a diffractive optical element on which the light is incident, the irradiation optical system being configured to apply illumination light in which a plurality of diffracted lights generated by the diffractive optical element are distributed; a flow cell in which a sample containing cells is caused to flow to a position at which the illumination light is applied by the irradiation optical system; and a light receiver configured to receive light generated from each cell flowing in the flow cell, upon application of the illumination light by the irradiation optical system. The illumination light includes zero-order diffracted light whose relative intensity relative to another diffracted light is not greater than 10 times. The irradiation optical system applies the illumination light to a position through which the cell in the flow cell passes.

公开(公告)号：US20240118272A1

公开(公告)日：2024-04-11

申请号：US18469093

申请日：2023-09-18

Applicant: SYSMEX CORPORATION

Inventor： Eiya TAMADA ,  Masatoshi Yanagida ,  Kazuto Yamashita ,  Elnaz Nakhael ,  Mami Onishi ,  Maria Kiriyama

IPC: G01N33/543 ,  C07K14/705 ,  C07K16/28

CPC classification number: G01N33/54333 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2896 ,  G01N2333/916 ,  G01N2496/00

Abstract: Disclosed is a method for measuring an activity of alkaline phosphatase contained in an extracellular vesicle in a sample, including acquiring an activity value of alkaline phosphatase contained in an extracellular vesicle in a sample using a calibrator, in which the calibrator contains a conjugate in which a polypeptide having alkaline phosphatase activity and a polypeptide including an amino acid sequence of a membrane protein present on a surface of the extracellular vesicle are covalently bound.