利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

135 条记录 (耗时 0.053 秒)

    Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist
    2.
    发明授权
    Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist 有权
    使用5-HT受体拮抗剂治疗或抑制与疼痛相关的非消化道的腹部疾病的方法

    公开(公告)号：US07820690B2

    公开(公告)日：2010-10-26

    申请号：US11080546

    申请日：2005-03-16

    申请人： Holger Sann

    发明人： Holger Sann

    IPC分类号： A61K31/437

    CPC分类号： A61K31/4184

    摘要： A method of treating or inhibiting non-digestive tract derived abdominal disorders associated with pain, in particular interstitial cystitis, chronic pelvic pain syndrome and/or abdominal pain associated with endometriosis, in a patient in need thereof, by administering to the patient a pharmaceutically effective amount of a 5-HT3 receptor antagonist, in particular cilansetron, or a pharmacologically compatible derivative thereof, such as a salt and/or a solvates.

    摘要翻译： 一种在有需要的患者中治疗或抑制与消化道衍生的腹部疾病有关的疼痛，特别是间质性膀胱炎，与子宫内膜异位症相关的慢性盆腔疼痛综合征和/或腹部疼痛的方法，通过向患者施用药学上有效的 5-HT 3受体拮抗剂的量，特别是西兰司琼或其药理学上相容的衍生物，例如盐和/或溶剂合物。

    Lipase Variants for Pharmaceutical Use
    3.
    发明申请
    Lipase Variants for Pharmaceutical Use 有权
    药用脂肪酶变体

    公开(公告)号：US20100034797A1

    公开(公告)日：2010-02-11

    申请号：US12519868

    申请日：2007-12-12

    申请人： Allan Svendsen ,  Michael Skjoet ,  Deborah Yaver ,  Lars Lehman Hylling Christensen ,  Signe Eskildsen Larsen ,  Nina Lundin ,  Michael Lamsa ,  Peter Colin Gregory

    发明人： Allan Svendsen ,  Michael Skjoet ,  Deborah Yaver ,  Lars Lehman Hylling Christensen ,  Signe Eskildsen Larsen ,  Nina Lundin ,  Michael Lamsa ,  Peter Colin Gregory

    IPC分类号： A61K38/54 ,  C12N9/20 ,  C12Q1/34 ,  A61K38/46

    CPC分类号： A61K38/465 ,  A61K38/47 ,  A61K38/48 ,  C12N9/20

    摘要： The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, an are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.

    摘要翻译： 与包含SEQ ID NO：2的氨基酸1-269的Thermomyces lanuginosus（Humicola lanuginosa）脂肪酶相关的脂肪酶的药物用途，任选地与蛋白酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 本发明的脂肪酶具有例如体外改进的消化性能，在中性范围内的pH值改善的活性，在低pH下的改进的稳定性，对蛋白酶降解是稳定的，和/或在存在时是稳定的 的胃蛋白酶和胆汁盐。 本发明还涉及确定脂肪酶的体外消化性能的方法以及T.lanuginosus的脂肪酶的某些新颖变体。

    Method and pharmaceutical compositions for treating or inhibiting renal dysfunctions, diseases or disorders, particularly in diabetic patients
    7.
    发明授权
    Method and pharmaceutical compositions for treating or inhibiting renal dysfunctions, diseases or disorders, particularly in diabetic patients 失效
    用于治疗或抑制肾功能异常，疾病或病症，特别是糖尿病患者的方法和药物组合物

    公开(公告)号：US07273860B2

    公开(公告)日：2007-09-25

    申请号：US10988847

    申请日：2004-11-16

    申请人： Dirk Thormaehlen ,  Berthold Hocher ,  Harald Waldeck

    发明人： Dirk Thormaehlen ,  Berthold Hocher ,  Harald Waldeck

    IPC分类号： A61K31/55

    CPC分类号： A61K31/55

    摘要： Treatment and/or inhibition of renal dysfunction, disease or disorder in larger mammals, and particularly in humans, especially in human patients suffering from diabetes, using benzazepine-N-acetic acid derivatives which contain an oxo-group in the α-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclopentylcarbonylamino radical, and/or salts or biolabile esters or physiologically acceptable solvates thereof, and production of pharmaceutical compositions and products suitable for treatment and/or inhibition of renal dysfunction, disease or disorder, particularly in diabetic patients, but also in patients with syndrome X or in patients with a renal dysfunction, disease and/or disorder, which patients are additionally hypertensive, obese, hyperglycemic and/or subject to a metabolic disorder.

    摘要翻译： 在大型哺乳动物，特别是人，特别是患有糖尿病的人类患者中，使用含有氧代基的苯并氮杂-N-乙酸衍生物，在α位置的治疗和/或抑制肾功能障碍，疾病或病症 氮原子，并且在3位上被1-（羧基烷基）环戊基羰基氨基取代，和/或其盐或生物不稳定酯或其生理学上可接受的溶剂合物，以及适于治疗和/或抑制肾功能障碍的药物组合物和产品的生产 或障碍，特别是在糖尿病患者中，而且在患有综合征X或患有肾功能障碍，疾病和/或障碍的患者中，该患者另外是高血压，肥胖，高血糖和/或经历代谢紊乱。

    Method and device for concentrating and stabilizing conjugated estrogens from mare urine
    9.
    发明申请
    Method and device for concentrating and stabilizing conjugated estrogens from mare urine 失效
    从母马尿中浓缩和稳定结合性雌激素的方法和装置

    公开(公告)号：US20060234994A1

    公开(公告)日：2006-10-19

    申请号：US11451472

    申请日：2006-06-13

    申请人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

    发明人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

    IPC分类号： A61K31/56 ,  C07J1/00

    CPC分类号： C07J1/00 ,  C07J75/00

    摘要： A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorbent cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.

    摘要翻译： 用于从固体吸附剂载体上浓缩和稳定来自怀孕母马的结合雌激素的方法和装置，以获得在马附近的药筒上含有共轭雌激素混合物的天然混合物的药物起始材料。 吸收剂盒可以装载在尿液收集部位，因此不需要将大量的尿液运送到中央处理点。 加载过程可以持续几周，直到色谱柱饱和。 流出的尿液保留在可处置设施的场所。 只有装载的墨盒才能运输，运输可能会在更长的间隔内进行，最长可达数周。 共轭雌激素对吸附剂的稳定性确保没有分解的危险。

    Method and apparatus for concentrating and stabilizing conjugated estrogens from mare urine
    10.
    发明授权
    Method and apparatus for concentrating and stabilizing conjugated estrogens from mare urine 失效

    公开(公告)号：US07081451B2

    公开(公告)日：2006-07-25

    申请号：US10112040

    申请日：2002-04-01

    申请人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

    发明人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

    IPC分类号： A61K31/56

    CPC分类号： C07J1/00 ,  C07J75/00

    摘要： A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is suitable for decentralized concentration and stabilization of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorber cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.