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公开(公告)号：US11883402B2
公开(公告)日：2024-01-30
申请号：US17275382
申请日：2019-09-12
发明人： Jong Ouk Baek , Hee Cheol Kim , Tae Hee Ha , Kweehyun Suh , Guru Reddy
IPC分类号： A61K31/517 , A61K33/243 , A61K31/282 , A61K31/337 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/475 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/655 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/7105 , A61K38/17 , A61K39/395 , C07D401/12
CPC分类号： A61K31/517 , A61K31/282 , A61K31/337 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/475 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/655 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/7105 , A61K33/243 , A61K38/179 , A61K39/3955 , C07D401/12 , C07B2200/13
摘要： This patent document relates to the crystalline forms of a quinazoline compound and the hydrochloride salts thereof. More particularly, this patent document relates to a preparation method of the crystalline forms of 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one and its hydrochloride salts.
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公开(公告)号：US20230027238A1
公开(公告)日：2023-01-26
申请号：US17781639
申请日：2020-12-04
发明人： Shanta Chawla , Gajanan Bhat
IPC分类号： A61K47/68 , A61K47/60 , A61P7/00 , A61K31/337 , A61K31/664
摘要： This disclosure provides a method of preventing, alleviating or treating a condition (i.e., neutropenia) in a subject in need thereof, the condition characterized by compromised white blood cell production in the subject. The method includes administering to the subject a therapeutically effective amount of a protein complex on the same day as a chemotherapy regimen, wherein the protein complex is a modified human granulocyte-colony stimulating factor (hG-CSF) covalently linked to an immunoglobulin Fc region via a non-peptidyl polymer. The non-peptidyl polymer is site-specifically linked to an N-terminus of the immunoglobulin Fc region, and the modified hG-CSF comprises substitutions in at least one of Cys17 and Pro65.
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公开(公告)号：US09295666B2
公开(公告)日：2016-03-29
申请号：US14015829
申请日：2013-08-30
发明人： Bastiaan Nuijen , Ernie Pfadenhauer , Jos H. Beijnen , Dorla Mirejovsky , Guru Reddy , Luigi Lenaz
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/0034 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/26
摘要： Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
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4.发明授权公开(公告)号：US08961917B2
公开(公告)日：2015-02-24
申请号：US13106637
申请日：2011-05-12
CPC分类号： A61K33/24 , A61K9/0056 , A61K9/0095 , A61K9/10 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/4866 , C01F17/005 , C01P2002/72 , C01P2004/03 , C01P2004/61 , C01P2006/10 , C01P2006/11 , C01P2006/12 , C01P2006/80
摘要： The present invention is a method of producing a lanthanum carbonate hydroxide or lanthanum oxycarbonate which has improved properties. The method involves the use of a water soluble lanthanum and a water soluble non-alkali metal carbonate or bicarbonate. The resulting material can be used as a phosphate binder individually or for treating patients with hyperphosphatemia.
摘要翻译： 本发明是一种具有改进性能的碳酸镧碳酸镧或碳酸镧的制造方法。 该方法涉及使用水溶性镧和水溶性非碱金属碳酸盐或碳酸氢盐。 所得材料可单独用作磷酸盐粘合剂或用于治疗高磷酸盐血症患者。
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5.发明授权Sensitization of tumor cells to radiation therapy through administration of endothelin agonists 有权通过给予内皮素激动剂使肿瘤细胞对放射治疗敏感公开(公告)号：US08957014B2
公开(公告)日：2015-02-17
申请号：US13761043
申请日：2013-02-06
发明人： Anil Gulati , Guru Reddy , Luigi Lenaz
IPC分类号： A61K38/00 , A61N5/00 , A61K41/00 , A61K31/00 , A61K31/28 , A61K31/337 , A61K31/4745 , A61K31/519 , A61K31/704 , A61K33/24 , A61K38/17 , A61K38/22 , A61K45/06 , A61N5/10
CPC分类号： A61K41/0038 , A61K31/00 , A61K31/28 , A61K31/337 , A61K31/4745 , A61K31/519 , A61K31/704 , A61K33/24 , A61K38/1703 , A61K38/2285 , A61K45/06 , A61N5/00 , A61N2005/1098 , A61K2300/00
摘要： Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ETB agonist IRL1620.
摘要翻译： 通过施用内皮素激动剂如ETB激动剂IRL1620使肿瘤细胞对放射治疗敏感的方法。
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公开(公告)号：US08815953B2
公开(公告)日：2014-08-26
申请号：US12381467
申请日：2009-03-12
IPC分类号： A61K31/12
CPC分类号： A61K47/14 , A61K9/0014 , A61K31/122
摘要： The present invention provides topical formulations containing a vitamin K analog, e.g., menadione, that deliver a uniform, therapeutically effective concentration of the vitamin K analog to the skin in a vehicle which is stable, non-irritating, non-drying and cosmetically acceptable. These topical formulations are useful for the treatment and prevention of dermatological conditions associated with inflammation, particularly, dermatological conditions resulting from anti-EGFR therapies.
摘要翻译： 本发明提供含有维生素K类似物（例如甲萘醌）的局部制剂，其在稳定的，无刺激性的，不干燥的和美容上可接受的载体中将维生素K类似物的均匀的治疗有效浓度提供给皮肤。 这些局部制剂可用于治疗和预防与炎症相关的皮肤病学疾病，特别是由抗EGFR治疗引起的皮肤病学病症。
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7.发明授权公开(公告)号：US08729023B2
公开(公告)日：2014-05-20
申请号：US13711519
申请日：2012-12-11
发明人： Anil Gulati , Guru Reddy , Luigi Lenaz
CPC分类号： A61K38/10 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7072 , A61K38/2013 , A61K38/21 , A61K38/2285 , A61K45/06 , A61K2300/00
摘要： Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.
摘要翻译： 公开了用于治疗癌症（包括实体瘤）的方法，组合物和制品。 方法，组合物和制品可以利用内皮素B激动剂（ETB）来增强化疗剂的递送和产生的功效。
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公开(公告)号：US08524762B2
公开(公告)日：2013-09-03
申请号：US13043333
申请日：2011-03-08
申请人： Steffan Nawrocki , Jennifer Carew , Guru Reddy
发明人： Steffan Nawrocki , Jennifer Carew , Guru Reddy
IPC分类号： A61K31/38
CPC分类号： A61K31/27 , A61K31/00 , A61K31/138 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/19 , A61K31/222 , A61K31/337 , A61K31/343 , A61K31/382 , A61K31/39 , A61K31/404 , A61K31/4045 , A61K31/4188 , A61K31/427 , A61K31/435 , A61K31/436 , A61K31/4406 , A61K31/4545 , A61K31/4706 , A61K31/495 , A61K31/506 , A61K31/517 , A61K31/69 , A61K31/7004 , A61K31/7048 , A61K33/36 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these compositions, and methods of treating cancer using such compounds, compositions and kits. Additionally, the present specification provides methods of treating cancer using a thioxanthone-based autophagy inhibitor and a radiotherapy.
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9.发明申请Methods for Treating Cognitive/Attention Deficit Disorders Using Tetrahydroindolone Analogues and Derivatives 有权使用四氢吲哚酮类似物和衍生物治疗认知/注意力缺陷障碍的方法公开(公告)号：US20120070385A1
公开(公告)日：2012-03-22
申请号：US13246014
申请日：2011-09-27
申请人： Alvin J. Glasky , David B. Fick , David Helton
发明人： Alvin J. Glasky , David B. Fick , David Helton
IPC分类号： A61K31/404 , A61P25/00 , A61K9/12
CPC分类号： C07D209/08 , C07D209/88
摘要： The present specification discloses tetrahydroindolone derivatives or analogues and methods for treating cognitive/attention deficit disorders using such tetrahydroindolone derivatives and analogues.
摘要翻译： 本说明书公开了使用这种四氢吲哚酮衍生物和类似物治疗认知/注意力缺陷障碍的四氢吲哚酮衍生物或类似物和方法。
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公开(公告)号：US20110251143A1
公开(公告)日：2011-10-13
申请号：US12809575
申请日：2008-12-19
申请人： Ashok Gore , Kwok Yin Tsang
发明人： Ashok Gore , Kwok Yin Tsang
IPC分类号： A61K31/7048 , A61P35/00
CPC分类号： A61K9/0019 , A61K31/7048 , A61K47/26
摘要： Formulations containing stable forms of elsamitrucin salts are provided. These formulations are useful for treating neoplastic diseases and conditions.
摘要翻译： 提供了含有稳定形式的依沙芦凝素盐的制剂。 这些制剂可用于治疗肿瘤疾病和病症。
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