公开(公告)号：US12121258B2

公开(公告)日：2024-10-22

申请号：US17128138

申请日：2020-12-20

申请人： Surmodics, Inc.

发明人： Derek Stratton ,  John Bridgeman

IPC分类号： A61B17/3207 ,  A61B17/00 ,  A61M25/10

CPC分类号： A61B17/320725 ,  A61M25/10 ,  A61M25/1011 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/00862 ,  A61M2025/1015 ,  A61M2025/1081 ,  A61M2205/0216 ,  A61M2207/00

摘要： In an example, a scoring device is configured for retention of a catheter shaft. The scoring device incudes a proximal portion and a distal portion. A retention sleeve extends between the proximal and distal portions. The retention sleeve has a catheter socket configured to selectively receive and mechanically engage the catheter shaft. The scoring device includes a scoring tool coupled with the retention sleeve, for instance proximate to the distal portion. The scoring tool includes a balloon socket configured to selectively receive a balloon of the catheter shaft. The scoring tool includes one or more scoring elements extending around the balloon socket, the one or more scoring elements configured to provide localized scoring to vasculature.

公开(公告)号：US20240342347A1

公开(公告)日：2024-10-17

申请号：US18612034

申请日：2024-03-21

申请人： Surmodics, Inc.

发明人： Syed Hossainy

IPC分类号： A61L33/00 ,  A61L29/08 ,  A61L29/16 ,  A61L33/06

CPC分类号： A61L33/0023 ,  A61L29/085 ,  A61L29/16 ,  A61L33/0064 ,  A61L33/062 ,  A61L2300/42

摘要： Embodiments herein relate to biofouling resistant coatings for medical devices. In an embodiment, an anti-fouling coated medical device is included having a substrate and a coating disposed over the substrate. The coating can include a hydrogel, and a polyzwitterion. The polyzwitterion can include a bound portion and an unbound portion. In some embodiments the coating can further include a heparin compound. Other embodiments are also included herein.

公开(公告)号：US11938250B2

公开(公告)日：2024-03-26

申请号：US16272808

申请日：2019-02-11

申请人： Surmodics, Inc.

发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

IPC分类号： A61L29/08 ,  A61K31/7024 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  G01N33/543

CPC分类号： A61L29/085 ,  A61K31/7024 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  G01N33/54393 ,  A61L2300/216 ,  A61L2300/418 ,  A61L2300/42 ,  A61L2400/04 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08

摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

公开(公告)号：US11529440B2

公开(公告)日：2022-12-20

申请号：US16847272

申请日：2020-04-13

申请人： Surmodics, Inc.

发明人： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

IPC分类号： A61L29/08 ,  A61L29/16 ,  A61L29/14 ,  A61K31/337 ,  A61K31/713 ,  A61K47/34 ,  A61M25/10 ,  C12N15/113 ,  A61K9/50

摘要： Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

公开(公告)号：US20220219194A1

公开(公告)日：2022-07-14

申请号：US17571095

申请日：2022-01-07

申请人： Surmodics, Inc.

发明人： Ralph A. Chappa

IPC分类号： B05D1/00 ,  A61L29/16 ,  A61L31/16 ,  A61M25/10

摘要： Embodiments herein relate to a system for coating rotatable medical devices and related methods. In an embodiment, a coating system for coating rotatable medical devices is included. The coating system can include a rotation mechanism, wherein the rotation mechanism is configured to mount and rotate a rotatable medical device. The coating system can also include a fluid applicator unit. The fluid applicator unit can include a rotating retention sleeve, the rotating retention sleeve defining a channel, wherein the rotatable medical device fits within the channel. The fluid applicator unit can also include a retention sleeve drive mechanism, wherein the retention sleeve drive mechanism is configured to rotate the rotating retention sleeve. The coating system can also include an inner collar, wherein the inner collar fits within the channel of the rotating retention sleeve. Other embodiments are also included herein.

公开(公告)号：US20220211917A1

公开(公告)日：2022-07-07

申请号：US17700212

申请日：2022-03-21

申请人： Surmodics, Inc.

发明人： Mike Militello

IPC分类号： A61L29/08 ,  A61L29/14

摘要： Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.

公开(公告)号：US20210330343A1

公开(公告)日：2021-10-28

申请号：US16483370

申请日：2019-06-05

申请人： SURMODICS, INC.

发明人： David Meerkin ,  Raphael BENARY ,  Yoav SHAKED

IPC分类号： A61B17/3207 ,  A61B17/221

摘要： Systems, devices and methods for treating a stenosed vessel or heart valve are disclosed. In some embodiments, a cutting/scoring assembly/device for treating a stenosed vessel/heart valve is provided and includes a main, elongated scoring sleeve or element with multiple longitude wires arranged at a distal end. A distal end of the elongated element is proximal to the multiple longitude wires which, when used in conjunction with a balloon catheter, is used to for, according to some embodiments, localized controlled longitudinal vessel incision.

公开(公告)号：US20210260255A1

公开(公告)日：2021-08-26

申请号：US17316244

申请日：2021-05-10

申请人： Surmodics, Inc.

发明人： David E. Babcock ,  Timothy M. Kloke ,  Joseph S. McGonigle

IPC分类号： A61L29/14 ,  A61L29/08 ,  C10M169/04 ,  C10M107/42 ,  A61L29/04 ,  C10M107/48 ,  C10M177/00 ,  C10M107/46 ,  C10M107/50 ,  B05D7/00 ,  C10M107/28 ,  C10M135/36

摘要： Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 μm or greater) which is very desirable for in vivo use.

公开(公告)号：US11000632B2

公开(公告)日：2021-05-11

申请号：US14148339

申请日：2014-01-06

申请人： SurModics, Inc.

发明人： David E. Babcock ,  Timothy M. Kloke ,  Joseph S. McGonigle

IPC分类号： A61L29/14 ,  A61L29/08 ,  C10M169/04 ,  C10M107/42 ,  A61L29/04 ,  C10M107/48 ,  C10M177/00 ,  C10M107/46 ,  C10M107/50 ,  B05D7/00 ,  C10M107/28 ,  C10M135/36 ,  C10N20/00 ,  C10N50/00

摘要： Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 μm or greater) which is very desirable for in vivo use.

公开(公告)号：US10758719B2

公开(公告)日：2020-09-01

申请号：US15838677

申请日：2017-12-12

申请人： Surmodics, Inc.

发明人： Charles Olson

IPC分类号： A61M39/06 ,  A61B17/34 ,  A61M39/00

摘要： Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.