公开(公告)号：US10777724B2

公开(公告)日：2020-09-15

申请号：US16049205

申请日：2018-07-30

Applicant: GAS TECHNOLOGY INSTITUTE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS MERCED CAMPUS ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS BERKELEY CAMPUS

Inventor： David Cygan ,  Hamid Abbasi ,  Aleksandr Kozlov ,  Roland Winston ,  Eli Yablonovitch

IPC: H01L35/02 ,  H01L31/046 ,  H02S40/22 ,  H02S40/44 ,  F24S23/70

Abstract: A hybrid solar system including a hybrid solar collector using non-imaging optics and photovoltaic components and a heat transfer and storage system in thermal communication with the hybrid solar collector, the heat transfer and storage system using particle laden gas as thermal media to simultaneously generate and store electricity and high temperature dispatchable heat.

公开(公告)号：US20190249172A1

公开(公告)日：2019-08-15

申请号：US16077982

申请日：2017-02-16

Applicant: The Regents of the University of California

Inventor： Donald B. Kohn ,  Carmen Flores Bjurstroem

IPC: C12N15/11 ,  C12N9/22 ,  C07K14/47

CPC classification number: C12N15/11 ,  C07K14/4747 ,  C12N9/22 ,  C12N15/10 ,  C12N15/102 ,  C12N2310/20 ,  C12N2800/80

Abstract: The present disclosure provides methods for gene editing in stem cells. The methods generally involve modifying the stem cells by increasing the level of an apoptosis regulator in the stem cells; and introducing into the modified stem cells a genome editing composition.

公开(公告)号：US20240063340A1

公开(公告)日：2024-02-22

申请号：US17642057

申请日：2020-09-10

Applicant: The Regents of the University of California

Inventor： Stacia Keller ,  Umesh K. Mishra ,  Shubhra Pasayat ,  Chirag Gupta

IPC: H01L33/32 ,  H01L33/16 ,  H01L33/12 ,  H01L25/075 ,  H01L33/20

CPC classification number: H01L33/32 ,  H01L33/16 ,  H01L33/12 ,  H01L25/0753 ,  H01L33/20

Abstract: The present disclosure describes porous GaN layers and/or compliant substrates used to enable relaxation of previously strained top layers and the deposition of relaxed or partially relaxed on top. Relaxed In GaN layers are fabricated without generation of crystal defects, which can serve as base layers for high performance long wavelength light emitting devices (LEDs, lasers) solar cells, or strain engineered transistors. Similarly, relaxed AlGaN layers can serve as base layers for high performance short wavelength UV light emitting devices (LEDs, lasers) solar cells, or wide bandgap transistors.

公开(公告)号：US20190256824A1

公开(公告)日：2019-08-22

申请号：US16096784

申请日：2017-05-01

Applicant: The Regents of the University of California

Inventor： Hooman Hefzi ,  Nathan E. Lewis

IPC: C12N9/04 ,  C12N9/12 ,  C12N15/90 ,  C12N5/071 ,  C12P21/00

Abstract: Provided are mammalian cells devoid of lactate dehydrogenase activity.

公开(公告)号：US20200269323A1

公开(公告)日：2020-08-27

申请号：US16305387

申请日：2017-05-23

Applicant: The Regents of the University of California

Inventor： Peidong Yang ,  Fan Cui ,  Letian Dou ,  Zhiqiang Niu

IPC: B22F9/24 ,  B22F1/00 ,  H01L31/0224 ,  H01L31/18

Abstract: Provided are methods for synthesizing metal nanowires in solution using an organic reducing agent. A reaction mixture can be provided in solution with a metal salt, the organic reducing agent, and a solvent, where the solvent includes a surface ligand or consists of a surface ligand. The organic reducing agent, such as benzoin, can be decomposed in the reaction mixture to form organic free radicals that reduce metal ions of the metal salt into metal. The surface ligand of the solvent can coordinate with the metal in a manner so that metal nanowires are formed in solution. The diameter and morphology of the nanowires, reaction speed, reaction yield, and other features may be tunable by adjusting parameters such as reaction temperature and chemistry of the reducing agent.

公开(公告)号：US20250105852A1

公开(公告)日：2025-03-27

申请号：US18891795

申请日：2024-09-20

Applicant: The Regents of the University of California

Inventor： Ian Andrew Galton

IPC: H03M1/06

Abstract: Some embodiments of the present disclosure include a digital-to-analog conversion system configured to reduce inter-symbol interference (ISI) in high-speed continuous-time DACs. The system can include a main DAC with multiple sub-DACs, each configured to process a portion of a digital input sequence and generate part of an output waveform. To address ISI errors introduced by the sub-DACs, the system can include an ISI mitigation feedback loop. The ISI mitigation feedback loop can include an analog-to-digital converter (ADC) that generates a digital sequence from the output waveform and an analog correction signal generated by a correction DAC. A fractional decimation filter can be used to adjust a sampling rate and attenuate high-frequency components. A digital error estimator can generate an error cancellation sequence by correlating encoder information with the input sequence. The correction DAC can use the error cancellation sequence to generate the analog correction signal.

公开(公告)号：US20250101507A1

公开(公告)日：2025-03-27

申请号：US18971678

申请日：2024-12-06

Applicant: The Regents of the University of California

Inventor： Logan Mulroney ,  Mark Akeson ,  Miten Jain ,  Hugh Olsen

IPC: C12Q1/6869 ,  C12P19/34

Abstract: Provided are methods of analyzing capped ribonucleic acids (RNAs). The methods include translocating an adapted RNA through a nanopore of a nanopore device. The adapted RNA includes an RNA region, a 5′ cap, and an adapter polynucleotide attached to the 5′ cap. The methods include monitoring ionic current through the nanopore during the translocating, translocating the 5′ cap through the nanopore, and identifying one or more ionic current features characteristic of the 5′ cap (e.g., a triphosphate linkage between the 5′ cap and nucleotide N1 of the RNA region, a 5′ to 5′ orientation of the 5′ cap and nucleotide N1 of the RNA region, and/or the like), translocating through the nanopore. Also provided are computer-readable media, computer devices, and systems that find use, e.g., in practicing the methods of the present disclosure.

公开(公告)号：US20250101108A1

公开(公告)日：2025-03-27

申请号：US18709427

申请日：2022-11-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Roger S. Lo ,  Zhentao Yang

IPC: C07K16/28 ,  A61K31/18 ,  A61K31/352 ,  A61K31/409 ,  A61K31/4162 ,  A61K31/454 ,  A61K31/519 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00

Abstract: Described are methods for enhancing cancer immune surveillance and the efficacy of the treatment of melanoma or non-melanoma cancers such as pancreatic or colorectal cancers, particularly by controlling cancer cell-surface PD-L1/L2 and the E3 ligase ITCH. Also described are methods of inhibiting an adaptive immune resistance response to anti-immune checkpoint protein therapy in a subject. As described herein, the efficacy of MAPK inhibitor therapy is increased by treatment with an activator of E3 ligase ITCH or a destabilizer of cell-surface PD-L1/L2. As further demonstrated herein, the efficacy of anti-PD-1/L1 therapy is also increased by treatment with an activator of E3 ligase ITCH or a destabilizer of cell-surface PD-L1/L2.

公开(公告)号：US20250099553A1

公开(公告)日：2025-03-27

申请号：US18970544

申请日：2024-12-05

Applicant: YOUHEALTH BIOTECH, LIMITED ,  The Regents of the University of California

Inventor： Kang ZHANG ,  Xin LI ,  Gen LI

IPC: A61K38/45 ,  A61K31/202 ,  A61K31/455 ,  A61K35/76 ,  A61K35/761 ,  A61K35/763 ,  A61K38/17 ,  A61K48/00 ,  A61P39/06

Abstract: Disclosed herein are therapeutic agents capable of increasing the expression level of an epigenetic marker described herein. Also described herein are therapeutic agents that reduce or slow-down an aging phenotype.

公开(公告)号：US20250099508A1

公开(公告)日：2025-03-27

申请号：US18726674

申请日：2023-01-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Faranak FATTAHI

IPC: A61K35/30 ,  C12N5/079

Abstract: The present disclosure relates generally to two-dimensional and three-dimensional cultures of cells, the cultures comprising one or a plurality of enteric neurons and/or one or a plurality of enteric glial cells. These cells and cultures can be used for screening compounds for neurologically active compounds, for transplantation into subjects for animal models, and for administration to a subject with a gut motility disorder.