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公开(公告)号：US20200171145A1
公开(公告)日：2020-06-04
申请号：US16783639
申请日：2020-02-06
发明人： Kari C. Nadeau
IPC分类号： A61K39/35 , A61K9/00 , A61K31/59 , A61K39/005 , A61K45/06 , A61K47/10 , A61K47/44 , A61K47/46 , A61K35/60 , A61K35/747 , A61K9/14 , A61K31/375 , A61K31/593
摘要： Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.
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公开(公告)号：US20180224557A1
公开(公告)日：2018-08-09
申请号：US15507860
申请日：2015-09-04
摘要： There is provided an apparatus comprising an antenna (105) configured to receive a signal from a global navigation satellite system, wherein the antenna includes a first feed and a second feed; a hybrid coupler (110) including a first hybrid input, a second hybrid input, a first hybrid output, a second hybrid output, and wherein the first hybrid output is shifted in phase by 90 degrees relative to the second hybrid output; a variable phase shifter (150) including a shifter input and a shifter output, hybrid output; and a combiner (155) including a first combiner input, a second combiner input, and a combiner output, wherein the first combiner input is coupled to the shifter output, and the second combiner input is coupled to the second hybrid output, and wherein the combiner output is provided to detection circuitry (197).
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3.发明申请公开(公告)号：US20180100865A1
公开(公告)日：2018-04-12
申请号：US15819500
申请日：2017-11-21
申请人： VIB VZW , Vrije Universiteit Brussel , The Board of Trustees of the Leland Stanford Junior University
发明人： Jan Steyaert , Els Pardon , Soren G.F. Rasmussen , Juan Jose Fung , Brian Kobilka , Toon Laeremans
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/705 , C07K14/723 , C07K16/28 , C07K2317/22 , C07K2317/33 , C07K2317/51 , C07K2317/56 , C07K2317/569 , C07K2317/75 , G01N23/20 , G01N33/566 , G01N33/68 , G01N33/6857 , G01N2333/726
摘要： The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
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公开(公告)号：US20240359009A1
公开(公告)日：2024-10-31
申请号：US18646450
申请日：2024-04-25
CPC分类号： A61N1/36046 , A61N1/0543
摘要： Systems and methods for calibration of retinal prosthetics in accordance with embodiments of the invention are illustrated. A closed loop calibration process is described whereby a multi-electrode stimulation regime can be calibrated to a given user's retina. Multi-electrode stimulation can provide increased stimulation selectivity, but significantly increases complexity. Systems and methods described herein provide computational steps that significantly reduce the amount of trials and computation required in order to achieve clinically viable selectivity, making closed-loop calibration of retinal prosthetics possible in significantly less time than open-loop calibration.
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公开(公告)号：US20240353302A1
公开(公告)日：2024-10-24
申请号：US18681312
申请日：2022-08-08
IPC分类号： G01N11/14
CPC分类号： G01N11/14
摘要： Improved rheometry is provided using an autonomous swimming robot that can be driven at least in an angular velocity mode and in a torque mode. The resulting improved capability can enable measurement of multiple rheological parameters, such as both normal stress components ψ1 and ψ2, by observing motion of the robot in the fluid. The robot is preferably rotationally symmetric. but with a fore-aft head-tail asymmetry that enables propulsion in complex fluids when the head and tail are driven to rotate opposite each other about the rotational axis of symmetry.
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公开(公告)号：US20240351996A1
公开(公告)日：2024-10-24
申请号：US18577851
申请日：2022-07-11
IPC分类号： C07D401/12 , A61K31/444 , A61K31/506 , C07D213/74 , C07D239/42 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14
CPC分类号： C07D401/12 , A61K31/444 , A61K31/506 , C07D213/74 , C07D239/42 , C07D239/48 , C07D401/06 , C07D401/14 , C07D405/14
摘要： Provided herein are compounds, tautomers, or pharmaceutically acceptable salts thereof, having a structure of formula (I): wherein X1, Y, Z1, Z2, (R1)n, (R2)m, and ring A are as described herein. Also provided are pharmaceutical compositions comprising compounds, tautomers, or pharmaceutically acceptable salts having a structure of formula (I). Further provided are a method of inhibiting cyclin dependent kinase 19 (CDK19) a method of treating breast cancer with the disclosed compounds.
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公开(公告)号：US20240350307A1
公开(公告)日：2024-10-24
申请号：US18642416
申请日：2024-04-22
发明人： Eduardo Jose Chichilnisky , Ruwan Amila Silva , Martin Breidenbach , Knut Skarpaas, VIII , Marco Oriunno
IPC分类号： A61F9/007
CPC分类号： A61F9/00727 , A61F2220/0033
摘要： A retina clip in accordance with embodiments of the invention are illustrated. One embodiment includes a retina clip including an outer ring having a means of retention against the retina, and an inner platform configured to hold a payload against the retina of an eye, where the inner platform is suspended from the inner ring via several springs. In many embodiments, the springs are flexures. The springs can be modified to generate a desired deflection based on a given payload attached to the inner platform. In numerous embodiments, the payload is a microelectrode array used as part of a retinal prosthetic.
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8.发明公开公开(公告)号：US20240348228A1
公开(公告)日：2024-10-17
申请号：US18631914
申请日：2024-04-10
申请人： The Board of Trustees of the Leland Stanford Junior University , Board of Regents, The University of Texas System
发明人： Eric Stolt , Juan Rivas-Davila , Weston Braun , Ruochen Lu , Kristi Nguyen
IPC分类号： H03H9/02 , H03H9/17 , H10N30/853
CPC分类号： H03H9/02086 , H03H9/17 , H10N30/8542
摘要： In certain examples, methods and apparatus are directed to a resonator-based circuit which, in operation, has an electrically-conductive band (“band”) at least partially surrounding a center electrode which includes the piezoelectric material of the circuit's resonator. In particular examples, the band acts to electrically load vibrations near resonance and consequently, spurious mode suppression is realized. In more particular example embodiments, the band maintains TE mode while eliminating lateral spurious tones, and in one application-specific example, the resonator-based circuitry and the electrical-conductive band are to provide of facilitate piezoelectric power conversion.
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公开(公告)号：US20240341607A1
公开(公告)日：2024-10-17
申请号：US18643950
申请日：2024-04-23
发明人： Nolan R. Williams , Keith Sudheimer
IPC分类号： A61B5/024 , A61B5/00 , A61B5/16 , A61N2/00 , A61N2/02 , G01R33/48 , G01R33/565 , G16H20/30 , G16H50/30
CPC分类号： A61B5/02405 , A61B5/165 , A61B5/4836 , A61N2/004 , A61N2/006 , A61N2/02 , G01R33/4806 , G01R33/4808 , G01R33/565 , G16H20/30 , A61B5/681 , A61B2576/026 , G16H50/30
摘要： Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
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公开(公告)号：US12110504B2
公开(公告)日：2024-10-08
申请号：US18501837
申请日：2023-11-03
申请人： The Board of Trustees of the Leland Stanford Junior University , The United States Government as represented by the Department of Veterans Affairs
发明人： Zurab Siprashvili , Ngon T. Nguyen , M. Peter Marinkovich , Jean Tang , Alfred T. Lane , Paul A. Khavari
CPC分类号： C12N5/0629 , A61K48/0058 , A61K48/0075 , A61K48/0091 , C12N2510/00 , C12N2760/16043
摘要： Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.
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