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    Functional soft materials and methods of making and using thereof
    1.
    发明授权
    Functional soft materials and methods of making and using thereof 有权

    公开(公告)号：US11460356B2

    公开(公告)日：2022-10-04

    申请号：US16895965

    申请日：2020-06-08

    申请人： THE UNIVERSITY OF KANSAS

    发明人： Cory Berkland ,  Jonathan Whitlow ,  Jean Salash

    IPC分类号： G01L1/12 ,  C09D11/037 ,  C09D11/102 ,  H01F7/20 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  B29K509/08 ,  H01F1/032 ,  B29C64/118 ,  B29K83/00 ,  B29K105/16

    摘要： Disclosed are functional materials for use in additive manufacturing (AM). The functional material can comprise an elastomeric composition (e.g., a silicone composite) for use in, for example, direct ink writing. The elastomeric composition can include and elastomeric resin, and a magnetic nanorod filler dispersed within the elastomeric resin. Nanorod characteristics (e.g., length, diameter, aspect ratio) can be selected to create 3D-printed constructs with desired mechanical properties along different axes. Furthermore, since nickel nanorods are ferromagnetic, the spatial distribution and orientation of nanorods within the continuous phase can be controlled with an external magnetic field. This level of control over the nanostructure of the material system offers another degree of freedom in the design of functional parts and components with anisotropic properties. Magnetic fields can be used to remotely sense compression of the constructs, or alternatively, control the stiffness of these materials.

    NEGATIVE PRESSURE AEROSOLIZATION MITIGATION DEVICES AND METHODS
    3.
    发明申请
    NEGATIVE PRESSURE AEROSOLIZATION MITIGATION DEVICES AND METHODS 有权

    公开(公告)号：US20210307985A1

    公开(公告)日：2021-10-07

    申请号：US17219330

    申请日：2021-03-31

    申请人： The University of Kansas

    发明人： Jared STAAB ,  Brent BARTA ,  Brigid FLYNN ,  Tim KRAUSE ,  Jay NACHTIGAL

    IPC分类号： A61G10/00 ,  A61G10/02

    摘要： An aerosolization mitigation device is provided. The aerosolization mitigation device can include a negative pressure aerosolization mitigation system. A transparent barrier can form a frame of the system, and a negative pressure can be generated in the internal volume. The device can isolate a patient to allow ambulatory, surgical, and routine care to proceed during periods of higher patient volume or viral transmission. The negative pressure environment mitigates viral transmission to protect healthcare providers and others in the vicinity of the patient from health risks during patient care.

    METHODS FOR GENERATING THERAPEUTIC DELIVERY PLATFORMS
    4.
    发明申请
    METHODS FOR GENERATING THERAPEUTIC DELIVERY PLATFORMS 有权

    公开(公告)号：US20210268121A1

    公开(公告)日：2021-09-02

    申请号：US17236561

    申请日：2021-04-21

    申请人： The University of Kansas ,  Kansas State University Research Foundation

    发明人： Mei He

    IPC分类号： A61K47/69 ,  G01N33/543 ,  G01N33/574

    摘要： Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.

    GRAPHENE OXIDE-BASED NANOLAB AND METHODS OF DETECTING OF EXOSOMES
    5.
    发明申请
    GRAPHENE OXIDE-BASED NANOLAB AND METHODS OF DETECTING OF EXOSOMES 有权

    公开(公告)号：US20210018501A1

    公开(公告)日：2021-01-21

    申请号：US17032037

    申请日：2020-09-25

    申请人： The University of Kansas ,  Kansas State University Research Foundation

    发明人： Peng Zhang ,  Yong Zeng ,  Mei He

    IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N33/68

    摘要： A graphene-based sandwich immunoassay for detecting whether a target biological substance is present in a sample, generally comprising contacting said sample with a plurality of particles coated with graphene nanosheets, each particle having at least one targeting receptor, such that the target biological substance, if present, associates with the targeting receptor, and detecting the presence of the target biological substance in the sample by subsequently contacting the sample with a detection antibody, wherein the detection antibody is capable of targeting and binding with the target biological substance if bound to the targeting receptor to yield a detectable complex. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome.

    Hydrogel precursors having nanoparticles
    8.
    发明授权
    Hydrogel precursors having nanoparticles 有权

    公开(公告)号：US10335515B2

    公开(公告)日：2019-07-02

    申请号：US14918229

    申请日：2015-10-20

    申请人： The University of Kansas

    发明人： Michael Detamore ,  Emily Beck ,  Stevin Gehrke ,  Cory Berkland

    IPC分类号： A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/20 ,  A61L27/38 ,  A61L27/50

    摘要： An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.

    Reprogramming of human wharton's jelly cells to produce hair cells
    9.
    发明授权
    Reprogramming of human wharton's jelly cells to produce hair cells 有权

    公开(公告)号：US10246681B2

    公开(公告)日：2019-04-02

    申请号：US15353244

    申请日：2016-11-16

    申请人： The University of Kansas

    发明人： Adam J Mellott ,  Michael Detamore ,  Hinrich Staecker

    IPC分类号： A61K35/30 ,  C12N15/113 ,  C12N5/0793

    摘要： A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells (hWJCs) to increase expression of or biological function of HATH1 so as to transform the hWJCs into MHCs. The method can include; administering a nucleic acid that encodes HATH1 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the hWJCs; administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the WJCs by administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5; nucleic acids are administered includes a sequence of SEQ ID NO: 2, SEQ ID NO: 3, and/or SEQ ID NO: 4.