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1.发明公开公开(公告)号：US20240327525A1
公开(公告)日：2024-10-03
申请号：US18293467
申请日：2022-07-29
申请人： VIB VZW , Universiteit Gent
CPC分类号： C07K16/2863 , C07K16/468 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to protein binding agents specifically binding the human cation-independent mannose-6-phosphate receptor (CI-M6PR), more specifically polypeptide agents comprising an immunoglobulin single variable domain (ISVD) specifically binding CI-M6PR at nano- to picomolar affinity, fused to further protein binding agents specifically binding extracellularly-accessible protein targets, such as membrane proteins, extracellular or secreted proteins. More specifically said CI-M6PR-specific ISVD recognizes CI-M6PR N-terminal domains 1, 2 and/or 3, thereby providing for means and methods for internalization, lysosomal targeting and degradation of agents comprising said ISVD, and of targets bound to said protein binding agents. The CI-M6PR binders disclosed herein are thus linked or fused to a further protein binding agent, in particular another antigen-binding protein, such as an ISVD or antibody, relevant for use in therapy, more specifically for treatment of diseases affected by said target antigen bound by said antigen-binding protein. More specifically disclosed herein are CI-M6PR ISVD fusions to antigen-binding proteins specifically binding EGFR, for treatment of cancer.
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公开(公告)号：US12105091B2
公开(公告)日：2024-10-01
申请号：US16761786
申请日：2018-11-06
申请人： VIB VZW , Universiteit Gent
发明人： An Hendrix , Olivier De Wever , Edward Geeurickx , Joke Vandesompele , Pieter Mestdagh , Sven Eyckerman
IPC分类号： G01N33/58 , C07K14/16 , C07K14/435 , C12Q1/6876 , G01N21/64 , G01N33/53
CPC分类号： G01N33/582 , C07K14/161 , C07K14/43595 , C12Q1/6876 , G01N21/6428 , G01N33/5308 , C07K2319/60 , C12Q2600/158 , G01N2021/6439 , G01N2496/30
摘要： This disclosure relates to the field of research and clinical usage of extracellular vesicles. More in particular, this disclosure relates to usages of recombinant extracellular vesicles comprising a) a self-assembling protein that directs its own release through vesicles as a luminal membrane-bound protein and b) a heterologous marker. Indeed, the disclosure provides recombinant extracellular vesicles that can be used as a biological reference material in methods to quantify extracellular vesicles in a sample, and/or, that can be used to calibrate a device for sample extracellular vesicles analysis, and/or, that can be used to evaluate the isolation process of extracellular vesicles. This disclosure thus relates to improving the accuracy of an extracellular vesicle-based diagnosis.
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3.发明公开公开(公告)号：US20240315259A1
公开(公告)日：2024-09-26
申请号：US18272752
申请日：2022-01-20
发明人： Danny GEELEN , Bruno CAMMUE , Geert HAESAERT , Tina KYNDT
摘要： The present invention relates to the use of a Distillers' Dried Grains with Solubles (DDGS) as a biopesticide and/or biostimulant in agriculture.
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公开(公告)号：US12091655B2
公开(公告)日：2024-09-17
申请号：US18551165
申请日：2022-03-22
申请人： UNIVERSITEIT GENT
CPC分类号： C12N13/00 , A61F9/00802 , A61F2009/00872 , A61F2009/00885
摘要： A method to selectively permeabilize and/or fragmentize cells. A structure comprising a material and particles able to absorb electromagnetic radiation and cells are brought at close distance from each other. Part of the particles embedded in the structure are exposed to the free surface of the structure. The structure and, in particular, the particles in the structure are irradiated with electromagnetic radiation to selectively permeabilize and/or fragmentize the cells. Furthermore, the disclosure relates to a structure for use in a photothermal process to selectively permeabilize and/or fragmentize cells.
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公开(公告)号：US12091490B2
公开(公告)日：2024-09-17
申请号：US17291049
申请日：2019-11-05
发明人： Aysu Arslan , Hugues van den Bergen , Patrice Roose , Dirk Bontinck , Sandra van Vlierberghe , Peter Dubruel
CPC分类号： C08G18/673 , C08G18/4244 , C08G18/4825 , C08G18/755 , C08L75/16 , C09D175/16
摘要： The present invention in general relates to acrylate end-capped urethane-based polymers, which are in particular characterized by the presence of at least 3 acrylate end-groups, thereby making them particularly suitable for further processing using multiple kinds of technologies such as 2-photon polymerization, stereolithography (SLA printing), electrospinning, film casting, porogen leaching, extrusion based 3D-printing, spray drying, cryogenic treatment, coatings, cross-linkable micelles, spincoating, and electrospraying.
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公开(公告)号：US20240180268A1
公开(公告)日：2024-06-06
申请号：US18524405
申请日：2023-11-30
申请人： IMEC VZW , Universiteit Gent
IPC分类号： A41D1/00 , D03D1/00 , D03D15/533 , D04B1/24 , D04B21/20
CPC分类号： A41D1/005 , D03D1/00 , D03D15/533 , D04B1/24 , D04B21/207 , D10B2401/18 , D10B2501/00
摘要： According to an aspect of the present inventive concept there is provided a textile device comprising: a first fabric comprising at least one electrically conductive wire; an electronic component, wherein the electronic component is fixated to the first fabric and wherein the at least one electrically conductive wire is electrically connected to the electronic component; wherein the textile device has a transition region at an area of the first fabric arranged laterally from the electronic component; wherein the textile device further comprises a strengthening element at the transition region, wherein the strengthening element comprises: a second fabric arranged around the first fabric; and a thermoplastic material arranged in relation to at least a first portion of the second fabric, wherein the thermoplastic material is arranged around the first fabric and fills a spacing between the first fabric and the second fabric at least in the first portion of the second fabric.
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公开(公告)号：US20240178573A1
公开(公告)日：2024-05-30
申请号：US18523134
申请日：2023-11-29
申请人： IMEC VZW , Universiteit Gent
发明人： Gert-Jan GORDEBEKE , Sam LEMEY , Hendrik ROGIER
摘要： A method is provided for designing an antenna comprising: i) determining dimensions of a fractional-mode, FM, air-filled, AF, antenna cavity, a FM-AF cavity, resonating around a target centre frequency characterized by a conductive ground cavity layer, a conductive top cavity layer, conductive cavity sidewalls between the top and ground cavity layer, and a side opening resulting from the fractional-mode; ii) adding a guard trace for shielding radiation from the side opening by adding sidewalls at a distance from the side opening; wherein the conductive top cavity layer is at least partially open over said distance thereby obtaining a radiating slot between the guard trace and the FM-AF cavity; wherein the FM-AF cavity and radiation slot forms an antenna cavity; iii) matching the impedance of the antenna cavity around the target centre frequency by adjusting the FM-AF and/or radiating slot dimensions within a maximum footprint.
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公开(公告)号：US11992011B2
公开(公告)日：2024-05-28
申请号：US16954976
申请日：2018-12-20
申请人： VIB VZW , UNIVERSITEIT GENT , TAMINCO BV
发明人： Willem Desmedt , Tina Kyndt , Bartel Vanholme
摘要： The present invention is in the field of agricultural pathogen control. More specifically the invention relates to compounds capable of inhibiting cinnamate-4-hydroxylase and their use for protecting plants against plant pathogens, in particular against nematodes, fungi and/or bacteria. The invention also provides for compositions comprising the same, methods of making the same, and methods of controlling plant disease.
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公开(公告)号：US20240168223A1
公开(公告)日：2024-05-23
申请号：US18388960
申请日：2023-11-13
申请人： IMEC VZW , Universiteit Gent
发明人： Emiel Dieussaert , YanLu Li , Roeland Baets
IPC分类号： G02B6/12
CPC分类号： G02B6/12011 , G02B6/12019 , G02B2006/12142 , G02B2006/12147
摘要： According to an aspect of the present inventive concept there is provided a photonic integrated circuit, PIC, comprising a waveguide array. Each waveguide is configured to guide a light signal. All guided light signals originate from a common light beam or multiple mutually coherent light beams.
Each waveguide is associated with a mutually unique modulator, providing modulation, by a modulation signal, of phase and/or amplitude of the light signal, forming a modulated light signal. The modulation signals of all modulators have a common modulation period, such that the modulated light signal comprises a plurality of sideband frequencies representing different orders of frequency shifts based on harmonics of the modulation period.
A free propagation unit comprising inputs associated with the waveguides receives the modulated light signals. The modulated light signals propagate freely in two spatial dimensions through the free propagation unit and interfere to form output signals. Different outputs of the free propagation unit receive light with different peak frequency corresponding to different sideband frequencies.-
公开(公告)号：US20240165261A1
公开(公告)日：2024-05-23
申请号：US18552838
申请日：2022-03-28
申请人： Universiteit Gent
发明人： Stefaan DE SMEDT , Koen RAEMDONCK
CPC分类号： A61K47/6903 , A61K47/61
摘要： The present invention is related to the field of intracellular delivery of membrane-impermeable materials. It provides compositions enabling the delivery of such membrane-impermeable materials into cells, applicable for both in vitro, in vivo and ex vivo delivery applications, as well as the use thereof in methods of cytosolic delivery of membrane-impermeable materials. The compositions and methods are particularly useful in biological research, diagnostic methods and the development of cell-based therapies.
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