CELLULAR MEMBRANE VESICLES AND USES THEREOF
    8.
    发明公开

    公开(公告)号:US20230390202A1

    公开(公告)日:2023-12-07

    申请号:US18032094

    申请日:2021-10-14

    IPC分类号: A61K9/127 C12N9/22

    摘要: The present invention provides a stable non-naturally occurring cellular membrane vesicle for delivering an active agent into a target cell. The cellular membrane vesicle comprises a biological membrane from a parent cell and a liquid medium encapsulated by the biological membrane. The liquid medium comprises an active agent and does not comprise a native cytoplasmic component of the parent cell. The biological membrane is specific for the target cell, and the active agent remains active upon delivery into the target cell. Also provided are methods for delivering the active agent with the cellular membrane vesicle and methods of preparing the cellular membrane vesicles.

    HUMAN SIMULATOR
    9.
    发明公开
    HUMAN SIMULATOR 审中-公开

    公开(公告)号:US20230270972A1

    公开(公告)日:2023-08-31

    申请号:US18143307

    申请日:2023-05-04

    IPC分类号: A61M21/02

    摘要: A monitoring system for use with a human simulator for simulating interaction between a human baby and a bonded human and method of operating thereof are disclosed. The simulator comprises a housing having an outer layer configured to contact the baby, the housing having a surface contoured to simulate a torso of the bonded human; a respiration simulation system configured to simulate a respiration motion of the bonded human; and a heartbeat simulation system configured to simulate a heartbeat of the bonded human. The monitoring system comprises a smart device having a first communication interface; one or more sensors for detecting one or more biological parameters of the bonded human; at least one processor programmed with machine readable instructions to activate the sensor(s) and to transmit a signal corresponding to the detected biological parameters from the first communication interface to a second communication interface connected to the simulator.