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公开(公告)号：US12036262B2
公开(公告)日：2024-07-16
申请号：US16766055
申请日：2018-11-21
发明人： Huang-Ge Zhang
IPC分类号： C07H21/04 , A61K9/127 , A61K9/14 , A61K9/51 , A61K36/9068 , C12N15/113 , B82Y5/00 , B82Y40/00
CPC分类号： A61K36/9068 , A61K9/1271 , A61K9/148 , A61K9/5176 , C12N15/113 , B82Y5/00 , B82Y40/00 , C12N2310/141 , C12N2330/10 , C12N2501/2322
摘要： Provided are methods for modulating gut microbiota in subjects. In some embodiments, the methods include administering to a subject an effective amount of a composition that includes a first edible plant-derived nanoparticle encapsulating an effective amount of RNA. Also provided are methods for preventing and/or treating gut dysbiosis, methods for modulating bacterial growth, methods for modulating inflammatory cytokines, methods for reducing migration of bacterial from the gut to gut-associated bloodstream, and compositions for use in the presently disclosed methods, including pharmaceutical compositions.
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公开(公告)号：US20240225460A1
公开(公告)日：2024-07-11
申请号：US18555308
申请日：2022-04-15
IPC分类号： A61B5/022
CPC分类号： A61B5/022
摘要： A novel method for assessing blood pressure stability uses a plurality of outcome parameters based on blood pressure measurements. An individual subject may be classified as of hypotensive, hypertensive, unstable, or normal based on the plurality of outcome measures, which are calculated based on a target blood pressure range and a plurality of expanding blood pressure ranges.
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公开(公告)号：US20240164786A1
公开(公告)日：2024-05-23
申请号：US18551043
申请日：2022-03-17
发明人： Mark SLAUGHTER , Guruprasad GIRIDHARAN , Michael SOBIESKI , Gretel MONREAL , Steven KOENIG , Jorge JIMINEZ , Landon TOMPKINS
CPC分类号： A61B17/12122 , A61B17/12031 , A61B17/12172 , A61B17/12177 , A61B2017/00367 , A61B2017/00628 , A61B2017/00632 , A61B2017/00867 , A61B2017/12095
摘要： Instruments and methods are disclosed for left atrial appendage (LAA) closure. An exemplary occluder comprises a lattice framework and an anchor. An exemplary delivery tool provides a catheter-based means of delivery of the occluder to the left atrium and LAA of a heart, such as a human heart, and deployment of the occluder by minimally invasive surgery.
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4.发明公开公开(公告)号：US20240025114A1
公开(公告)日：2024-01-25
申请号：US18233416
申请日：2023-08-14
发明人： Keng Hsu , Alireza Tofangchi , Thomas A. Berfield
IPC分类号： B29C64/209 , B29C64/227 , B29C64/295 , B29C64/118
CPC分类号： B29C64/209 , B29C64/227 , B29C64/295 , B29C64/118 , B29K2995/0003 , B33Y40/00
摘要： Methods and systems for producing a structure having selectable piezoelectric properties via additive manufacturing. Such methods can include coupling an ultrasound generating device to a print head of the additive manufacturing apparatus; transmitting acoustic energy from the ultrasound generating device to the print head to vibrate the print head in an oscillatory manner; extruding a feed material from the print head; moving the print head in at least one dimension relative to a substrate on which the structure is being manufactured; and dispensing layers sequentially on top of each other to form the structure. Such systems can include an additive manufacturing apparatus comprising a print head movable in at least one dimension relative to a base configured to support the structure being produced; and an ultrasound generating device that is connected to the print head.
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公开(公告)号：US20240024387A1
公开(公告)日：2024-01-25
申请号：US18248491
申请日：2021-10-15
IPC分类号： A61K35/747 , B33Y10/00 , A61K35/745 , B33Y70/10 , A61K9/20 , A61P31/04
CPC分类号： A61K35/747 , B33Y10/00 , A61K35/745 , B33Y70/10 , A61K9/2095 , A61K9/205 , A61P31/04 , C12R2001/23
摘要： A probiotic delivery system is provided, as are methods of making and using such a probiotic delivery system.
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公开(公告)号：US11875892B2
公开(公告)日：2024-01-16
申请号：US16628795
申请日：2018-07-07
CPC分类号： G16H30/40 , G06N3/08 , G06N7/01 , G06N20/20 , G06T7/11 , G06T2207/20081 , G06T2207/20084
摘要： Methods for segmenting medical images from different modalities include integrating a plurality of types of quantitative image descriptors with a deep 3D convolutional neural network. The descriptors include: (i) a Gibbs energy for a prelearned 7th-order Markov-Gibbs random field (MGRF) model of visual appearance, (ii) an adaptive shape prior model, and (iii) a first-order appearance model of the original volume to be segmented. The neural network fuses the computed descriptors to obtain the final voxel-wise probabilities of the goal regions.
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7.发明公开公开(公告)号：US20240009256A1
公开(公告)日：2024-01-11
申请号：US17797219
申请日：2021-02-04
发明人： Wenke Feng , Craig J. McClain
IPC分类号： A61K35/747 , A61K9/127 , A61K31/405 , A61K31/404 , A61P1/16 , A61P1/04 , C12N1/20
CPC分类号： A61K35/747 , A61K9/127 , A61K31/405 , A61K31/404 , A61P1/16 , A61P1/04 , C12N1/20
摘要： Provided are probiotic bacterium-derived extracellular micro- and/or nanoparticles. Also provided are methods for purifying the probiotic bacterium-derived extracellular micro- and/or nanoparticles and methods for using the disclosed probiotic bacterium-derived extracellular micro- and/or nanoparticles to treat liver diseases and/or disorders including but not limited to acute liver failure (ALT), alcoholic liver disease (ALD), non-alcoholic liver disease, alcoholic hepatitis (AH), liver steatosis, liver fibrosis and/or cholestatic liver disease; increasing intestinal aryl hydrocarbon receptor (AhR) activity, Nrf2 signaling, IL-22 expression, regenerating islet-derived 3β (Reg3P) expression, and/or regenerating islet-derived 3γ (Reg3y) expression; maintaining gut microbiota homeostasis; preventing or reducing bacterial intestinal transcytosis; increasing intestinal tight junctions; decreasing circulating LPS concentration; protecting intestinal barrier integrity against oxidative stress; regulating intestinal Nrf2 signaling; increasing intestinal EGF secretion, hepatic macrophage HB-EGF cleavage and activation; and hepatic EGER activation.
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公开(公告)号：US20230355525A1
公开(公告)日：2023-11-09
申请号：US18214335
申请日：2023-06-26
发明人： Huang-Ge Zhang
IPC分类号： A61K31/353 , A61K9/127 , A61K31/337 , A61K33/243 , A61K45/06 , A61K31/282 , A61K31/12 , A61K31/704 , A61K31/475 , A61K31/05 , A61K31/513 , A61K31/575
CPC分类号： A61K9/127 , A61K31/05 , A61K31/12 , A61K31/282 , A61K31/337 , A61K31/353 , A61K31/475 , A61K31/513 , A61K31/575 , A61K31/704 , A61K33/243 , A61K45/06
摘要： An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions that contain the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.
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公开(公告)号：US11759677B2
公开(公告)日：2023-09-19
申请号：US16969279
申请日：2019-02-14
发明人： Thomas J. Roussel , Susan J. Harkema , Alexander V. Ovechkin , Yangshen Chen , Kevin Tran , Edward Hoyt Brown, Jr.
CPC分类号： A63B23/18 , A63B24/0062 , A63B71/0622 , A61M16/0833 , A61M16/0858 , A61M16/208 , A61M2016/0027 , A61M2205/8206 , A63B2071/0625 , A63B2071/0675 , A63B2225/20 , A63B2225/50 , A63B2230/40
摘要： A respiratory training device providing both inspiratory and expiratory functional evaluation and training, as well as independent regulation of both the inspiratory and expiratory airway resistance levels used during training. The respiratory training device also includes data acquisition, recording, storage, retrieval and display functions for airway pressure monitoring data to provide functional evaluation, physiological monitoring, and diagnostic features. The respiratory training device allows the user to easily develop and follow precise and advanced training protocols, and utilize the respiratory device in both the clinical and home setting.
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公开(公告)号：US11744839B2
公开(公告)日：2023-09-05
申请号：US17224368
申请日：2021-04-07
申请人： KOREA BASIC SCIENCE INSTITUTE , University of Louisville Research Foundation, Inc. , Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
IPC分类号： A61K31/00 , A61K31/655 , A61K38/12 , A61K31/4245 , A61K31/426 , A61K31/4196 , A61K31/506 , A61K31/404 , A61K31/343 , A61K31/4184 , A61K31/55 , A61K31/4709 , A61K31/4422 , A61K31/4725 , A61K31/196 , A61K31/4402 , A61K31/4418 , A61K31/41
CPC分类号： A61K31/655 , A61K31/196 , A61K31/343 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/4196 , A61K31/426 , A61K31/4245 , A61K31/4402 , A61K31/4418 , A61K31/4422 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/55 , A61K38/12
摘要： Method of increasing platelet counts in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound that inhibits Biliverdin reductase B (BLVRB) activity by blocking a binding site of BLVRB or a pharmaceutically acceptable salt thereof, wherein the compound does not contain xanthene or acridine moiety is provided.
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