-
公开(公告)号：US20250042983A1
公开(公告)日：2025-02-06
申请号：US18717623
申请日：2022-12-09
Inventor： Debasish SINHA , Urvi GUPTA , Sayan GHOSH , Peng SHANG , Stacey HOSE , Nadezda Anatolyevna STEPICHEVA , Jose Alain SAHEL
Abstract: Disclosed are monoclonal antibodies, and antigen binding portions thereof, which neutralize human Lipocalin 2 (LCN-2). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also disclosed. Related methods of reducing or preventing ferroptotic death of retinal pigmented epithelium (RPE) cells, methods of reducing or preventing one or both of lipid peroxidation and inflammasome activation in RPE cells, methods of reducing or preventing a decrease in one or both of scotopic a- and b-wave responses in a retina, methods of increasing one or both of scotopic a- and b-wave responses in a retina, methods of increasing one or both of autophagy and glutathione peroxidase activity in RPE cells, and methods of treating or preventing age-related macular degeneration (AMD) are also disclosed.
-
公开(公告)号：US12214150B2
公开(公告)日：2025-02-04
申请号：US17611486
申请日：2020-05-15
Inventor： Louis D. Falo, Jr. , Emrullah Korkmaz
Abstract: The disclosed methods relate to forming microneedle arrays from a production mold that comprises a flexible mold material. The disclosed methods can be used to reproducibly manufacture undercut dissolvable and coated microneedle arrays with various shapes and structures.
-
公开(公告)号：US12213800B2
公开(公告)日：2025-02-04
申请号：US18206401
申请日：2023-06-06
Inventor： Alexander Star , Sean Ihn Young Hwang
IPC: A61B5/1477 , A61B5/00 , A61B5/08 , A61B5/097 , A61B5/1455 , C01B32/159 , C01B32/198 , G01N33/94
Abstract: A device for detection of a cannabinoid in a sample includes a sensor including a substrate and a sensor medium on the substrate. The sensor medium includes at least one nanostructure, wherein at least one property of the sensor medium is dependent upon the presence of the cannabinoid on a surface of the sensor medium. The device further includes electronic circuitry including at least one measurement system in operative connection with the sensor to measure a variable relatable to the at least one property of the sensor medium dependent upon the presence of the cannabinoid.
-
公开(公告)号：US20250032044A1
公开(公告)日：2025-01-30
申请号：US18714863
申请日：2023-03-30
Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , NORTHEASTERN UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRS
Inventor： Murat Akcakaya , Deniz Kocanaogullari , Emily Grattan , George F. Wittenberg , Jennifer Mak , Sarah Ostadabbas , Xiaofei Huang
Abstract: A method of determining an extent of visual spatial neglect of a patient includes providing a software-based test to the patient via a presentation apparatus positioned on the head of the patient and having a display device positioned close and in front of the eyes of the patient. EEG information is collected from the patient during the test via an EEG apparatus positioned on the head of the patient. Portions of the EEG information collected during the test are used to determine the extent of the visual spatial neglect of the patient. An indication of the extent of the visual spatial neglect of the patient is provided.
-
5.发明授权
公开(公告)号：US12188019B2
公开(公告)日：2025-01-07
申请号：US17144365
申请日：2021-01-08
Inventor： Ramon Bataller Alberola , Jose Maria Argemi Ballbe
IPC: C12N15/113
Abstract: Provided herein are antisense agents for knocking down, inhibiting, or silencing expression of an HNF4α-P2 isoform mRNA in a cell or a patient. Also provided are methods of knocking down, inhibiting, or silencing expression of an HNF4α-P2 isoform mRNA in a cell or a patient and methods of treating a patient with liver disease, liver damage, liver inflammation, or liver failure, such as acute liver failure, ALD, AH, or ACLF.
-
公开(公告)号：US20250002549A1
公开(公告)日：2025-01-02
申请号：US18817667
申请日：2024-08-28
Inventor： Alan H. Wells
Abstract: Recombinant C-X-C motif chemokine ligand (CXCL) peptides modified to introduce a cleavage site for a protease, such as a protease activated during an inflammatory response, are described. The CXCL peptides have the capacity to activate CXCR3 until being cleaved by the protease. Proteolytic cleavage of the CXCL peptide minimizes the pro-inflammatory response and inhibits the development of fibrosis.
-
公开(公告)号：US20250001111A1
公开(公告)日：2025-01-02
申请号：US18579025
申请日：2022-07-14
Inventor： Carl H. Snyderman , Nikki Cwalina , Brinden Elton , Maxwell Baxter , Garrett N. Coyan
Abstract: Disclosed herein are endotracheal tubes that have multiple inflatable cuffs to help form a seal for ventilation, to reduce unwanted migration of the tube relative to the patient, reduce focalized pressure from a single cuff, and to help prevent aspiration of materials between the outside of the tube and the tracheal walls. Some devices include first and second distal cuffs for placement within the trachea and a proximal third cuff for blocking the entrance to the trachea. The cuffs can include ridges or textures to enhance sealing. The device can also include inflation channels, vacuum channels, and pressure sensors.
-
公开(公告)号：US12183521B2
公开(公告)日：2024-12-31
申请号：US18330465
申请日：2023-06-07
Inventor： Jung-Kun Lee , Gillsang Han
IPC: H01L31/0725 , H01G9/00 , H01G9/20 , H10K30/35 , H10K30/82
Abstract: Various perovskite solar cell embodiments include a flexible metal substrate (e.g., including a metal doped TiO2 layer), a perovskite layer, and a transparent electrode layer (e.g., including a dielectric/metal/dielectric structure), wherein the perovskite layer is provided between the flexible metal substrate and the transparent electrode layer. Also, various tandem solar cell embodiments including a perovskite solar cell and either a quantum dot solar cell, and organic solar cell or a thin film solar cell.
-
公开(公告)号：US12180474B2
公开(公告)日：2024-12-31
申请号：US17194706
申请日：2021-03-08
Inventor： Satdarshan Monga , Kari Nejak-Bowen
IPC: C12N15/113 , A61K31/444 , A61K31/519 , A61P1/16
Abstract: A method of treating porphyria in a patient is provided comprising knocking down or reducing expression or activity of β-catenin in the patient. e.g., in the liver of a patient, to an extent effective to treat porphyria in a patient.
-
公开(公告)号：US12178341B2
公开(公告)日：2024-12-31
申请号：US17357003
申请日：2021-06-24
Inventor： Alexandra Marie Delazio , David M. Brienza , Patricia Karg
Abstract: A device for use with a beverage can to secure a straw thereto includes a base configured to cooperate with an opening of the beverage can to secure the device to the beverage can and a passage formed through the base which aligns with the opening of the beverage can when the device is secured to the beverage can. The passage is configured to pass a straw therethrough.
