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公开(公告)号：US20200065278A1
公开(公告)日：2020-02-27
申请号：US16610452
申请日：2018-06-01
IPC分类号： G06F13/36 , G06F9/4401 , G06F1/3215
摘要： A system-on-a-chip (SoC) comprises a power supply circuit coupled to an energy harvesting transducer and configured to operate using energy from the energy harvesting transducer; a microcontroller coupled to a system bus of the SoC; an interface configured to communicate with the microcontroller via the system bus of the SoC, the interface configured to generate data upon occurrence of an event; and a computation accelerator configured to establish, based on an energy consumption level of the SoC, a data path between the interface and the computation accelerator that at least partially bypasses the system bus such that the data is transmitted to the computation accelerator via the data path.
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公开(公告)号：US11621876B2
公开(公告)日：2023-04-04
申请号：US17053533
申请日：2019-05-09
发明人： Maite Brandt-Pearce , Jie Lian
IPC分类号： H04B10/00 , H04L27/26 , H04B10/556 , H04J14/00 , H04B10/116
摘要： A system and method for communication of digital data includes receiving a plurality of data bits to be transmitted, and generating an output signal for transmission by a transmitter circuit. The generating includes generating a portion of the output signal comprising values of the output signal with magnitude less than a specified threshold, the specified threshold corresponding to a specified transmitter circuit maximum output power; and generating a portion of the output signal comprising a representation of values of the output signal with magnitude greater than the specified threshold.
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公开(公告)号：US20230099030A1
公开(公告)日：2023-03-30
申请号：US17907773
申请日：2021-03-19
IPC分类号： C08L71/12 , B01J41/13 , C08G65/48 , H01M50/423 , H01M8/103 , H01M8/18 , H01M8/04082 , H01M8/04186 , C25B13/08
摘要： An ion conducting polymer comprising a modified poly(phenylene oxide) is described. In an exemplary modified polymer, a portion of the monomeric units are attached to a sulfonate-substituted arylamino moiety, such as a monovalent derivative of phenoxy aniline trisulfonate (BOATS), to form a monomeric unit with a charged side chain. Ion conducting polymers can also be prepared with polyether-containing side chains. The ion conducting polymer can be used to prepare ion exchange membranes which can be used in a variety of applications, such as in non-aqueous redox flow batteries and related energy storage systems.
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公开(公告)号：US20230043806A1
公开(公告)日：2023-02-09
申请号：US17434692
申请日：2020-02-28
摘要： Methods and compositions for treating cancer in a subject in need thereof. The method includes administering to the subject an effective amount of a composition comprising Tumor-Targeting Effectors (TITE) derived from a culture comprising a bispecific antibody armed activated T cell (BAT) and a cancer cell, to thereby treat cancer in the subject.
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公开(公告)号：US20230025608A1
公开(公告)日：2023-01-26
申请号：US17170044
申请日：2021-02-08
发明人： Donald F. Hunt , Jeffrey Shabanowitz , Stacy Alyse Malaker , Victor H. Engelhard , Angela L. Ambakhutwala , Kara L. Cummings , Rebecca C. Obeng , Mark Cobbold
摘要： A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.
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公开(公告)号：US20220415440A1
公开(公告)日：2022-12-29
申请号：US17864710
申请日：2022-07-14
发明人： Chunkun BO , Kevin SKADRON , Elaheh SADREDINI , Vinh DANG
IPC分类号： G16B30/00 , G06N5/04 , G06F16/903
摘要： A method of operating a finite state machine circuit can be provided by determining if a target sequence of characters included in a string of reference characters occurs within a specified difference distance using states indicated by the finite state machine circuit to indicate a number of character mis-matches between the target sequence of characters and a respective sequence of characters within the string of reference characters.
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公开(公告)号：US20220401580A1
公开(公告)日：2022-12-22
申请号：US17776563
申请日：2020-11-12
摘要： Provided are nucleotide sequences encoding polypeptides with ribonuclease III activity, wherein the nucleotide sequences have been modified to reduce their regulation by miRNAs. In some embodiments, the nucleotide sequences are at least 50% and as much as 100% identical to SEQ ID NO: 20 or SEQ ID NO: 22, and/or encode polypeptides that are at least 90% percent identical to SEQ ID NO: 23. Also provided are vectors and host cells that include the nucleotide sequences, methods for expressing the nucleotide sequences in cells, tissues, and organs, which in some embodiments can be in the eye of a subject in need thereof, methods for preventing and/or treating development of diseases or disorders and/or for restoring undesirably low DICER1 expression using the nucleotide sequences, and pharmaceutical compositions that have the presently disclosed nucleotide sequences.
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公开(公告)号：US20220357416A1
公开(公告)日：2022-11-10
申请号：US17732155
申请日：2022-04-28
IPC分类号： G01R33/565 , G01R33/561
摘要： Methods, computing devices, and MRI systems that reduce artifacts produced by Maxwell gradient terms in TSE imaging using non-rectilinear trajectories are disclosed. With this technology, a RF excitation pulse is generated to produce transverse magnetization that generates a NMR signal and a series of RF refocusing pulses to produce a corresponding series of NMR spin-echo signals. An original encoding gradient waveform comprising a non-rectilinear trajectory is modified by adjusting a portion of the original encoding gradient waveform or introducing a zero zeroth-moment waveform segment at end(s) of the original encoding gradient waveform. During an interval adjacent to each of the series of RF refocusing pulses a first gradient pulse is generated. At least one of the first gradient pulses is generated according to the modified gradient waveform. An image is constructed from generated digitized samples of the NMR spin-echo signals obtained.
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公开(公告)号：US11466243B2
公开(公告)日：2022-10-11
申请号：US16322691
申请日：2017-08-03
IPC分类号： C12M1/36 , G05B19/042 , G05B23/02
摘要： The present invention provides a bioreactor controller with a simple user interface comprising a microcontroller and a linear motor. The bioreactor controller is microcontroller-based, has a greater temporal accuracy, and inexpensive. The microcontroller of the bioreactor controller selects a protocol mode and a setup mode by the user, runs the protocol mode if the setup mode is not selected by the user, stops running the protocol mode for a predetermined time if the protocol mode is selected by the user until the user is completed with calculations and record-keeping, detects movement error of the bioreactor controller, and informs the error to the user.
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公开(公告)号：US20220305083A1
公开(公告)日：2022-09-29
申请号：US17519489
申请日：2021-11-04
摘要： This application generally relates to stable peptide compositions and kits comprising low levels of buffering and chelating agents, and methods of using the same.
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