公开(公告)号：US11969474B2

公开(公告)日：2024-04-30

申请号：US15972758

申请日：2018-05-07

申请人： Wyeth LLC

发明人： A. Krishna Prasad

IPC分类号： A61K47/64 ,  A61K39/00 ,  A61K39/09

CPC分类号： A61K47/646 ,  A61K39/092 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.

公开(公告)号：US20220170107A1

公开(公告)日：2022-06-02

申请号：US17522637

申请日：2021-11-09

申请人： Wyeth LLC

发明人： Anna Berkenblit ,  Christina Marie Coughlin ,  Jay Marshall Feingold ,  Daniel Stephen Johnston ,  Andrew Louis Strahs ,  Charles Michael Zacharchuk

IPC分类号： C12Q1/6886 ,  A61K31/4709 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

摘要： Methods for treating breast cancer, specifically cancers resistant to treatment With one or more known breast cancer treatment drugs, and related patient selection strategies for predicting patient response to drug therapy, such strategies including detecting tile presence or absence in a patient of one or more of PIK3CA gene amplification a mutation in PIK3CA, and a decrease in PTEN protein expression, and treating a patient positive for the presence of one or more of same by administering to the subject a pan-ErbB tifrosine kinase inhibitor.

公开(公告)号：US11191830B2

公开(公告)日：2021-12-07

申请号：US16528680

申请日：2019-08-01

申请人： Wyeth LLC

发明人： William P. Hausdorff ,  George Rainer Siber ,  Peter R. Paradiso

IPC分类号： A61K39/09 ,  A61K39/39 ,  A61K47/64 ,  A61K39/385 ,  A61K39/00

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.

公开(公告)号：US11179369B2

公开(公告)日：2021-11-23

申请号：US16672296

申请日：2019-11-01

申请人： Wyeth, LLC

发明人： Eric Joel Benjamin ,  Wendy Ann Dulin ,  Yanning Lin ,  Kai Zhuang

IPC分类号： A61K31/407 ,  A61K9/20 ,  A61K9/28

摘要： The present invention provides controlled release dosage formulations of compounds having the Formula: or pharmaceutically acceptable salts thereof, and in particular, aplindore. The dosage forms are useful, inter alia, for reducing side effects from administration of such compounds.

公开(公告)号：US10780160B2

公开(公告)日：2020-09-22

申请号：US15972953

申请日：2018-05-07

申请人： Wyeth LLC

发明人： William P. Hausdorff ,  George Rainer Siber ,  Peter R. Paradiso

IPC分类号： A61K39/09 ,  A61K39/39 ,  A61K47/64 ,  A61K39/385 ,  A61K39/00

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.

公开(公告)号：US10588975B2

公开(公告)日：2020-03-17

申请号：US15613588

申请日：2017-06-05

申请人： Wyeth LLC

发明人： Mahdi B. Fawzi ,  Tianmin Zhu ,  Syed M. Shah

IPC分类号： A61K31/65 ,  A61K47/26 ,  A61K47/02 ,  A61K9/08 ,  A61K9/19 ,  A61K9/00

摘要： The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.

公开(公告)号：US10512681B2

公开(公告)日：2019-12-24

申请号：US15587574

申请日：2017-05-05

申请人： Wyeth LLC

发明人： Annaliesa Sybil Anderson ,  Kathrin Ute Jansen ,  Mark Edward Ruppen ,  Justin Keith Moran ,  Susan Kay Hoiseth

IPC分类号： A61K39/095 ,  C07K14/22 ,  C07K16/12 ,  A61K39/00

摘要： The present invention relates to compositions including an isolated non-pyruvylated non-lipidated ORF2086 polypeptide, and methods thereof. In an exemplary embodiment, the compositions described herein are immunogenic. The present invention further relates to compositions that elicit a bactericidal immune response in a mammal against an ORF2086 subfamily B polypeptide from serogroup B Neisseria meningitidis, and methods related thereto.

公开(公告)号：US10370424B2

公开(公告)日：2019-08-06

申请号：US15820527

申请日：2017-11-22

申请人： WYETH LLC

发明人： John Wozney ,  Howard Seeherman ,  Christopher Todd Brown

IPC分类号： A61K38/18 ,  C07K14/51 ,  C12N15/09 ,  A61K38/00

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

公开(公告)号：US10357449B2

公开(公告)日：2019-07-23

申请号：US15158967

申请日：2016-05-19

申请人： Syed M. Shah ,  Christian Ofslager ,  Mahdi B. Fawzi ,  Nataliya Bazhina

发明人： Syed M. Shah ,  Christian Ofslager ,  Mahdi B. Fawzi ,  Nataliya Bazhina

IPC分类号： A61K9/00 ,  A61K47/18 ,  A61K47/02 ,  A61K31/485

摘要： The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.

公开(公告)号：US10307417B2

公开(公告)日：2019-06-04

申请号：US16219681

申请日：2018-12-13

申请人： Wyeth, LLC

发明人： Syed M. Shah ,  Christopher Richard Diorio ,  Eric C. Ehrnsperger ,  Xu Meng ,  Kadum A. Al Shareffi ,  Jonathan Marc Cohen

IPC分类号： A61K31/485 ,  A61K9/20 ,  C07D489/08 ,  A61K9/00 ,  A61K47/20 ,  A61K47/12 ,  A61K9/28

摘要： The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.