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1886 条记录 (耗时 0.056 秒)

    ENGINEERED ANTIBODIES AS MOLECULAR DEGRADERS THROUGH CELLULAR RECEPTORS
    3.
    发明申请
    ENGINEERED ANTIBODIES AS MOLECULAR DEGRADERS THROUGH CELLULAR RECEPTORS 有权

    公开(公告)号：US20230090282A1

    公开(公告)日：2023-03-23

    申请号：US17654984

    申请日：2022-03-15

    申请人： YALE UNIVERSITY

    发明人： David SPIEGEL ,  David CAIANIELLO ,  Emily BRANHAM

    IPC分类号： A61K47/68

    摘要： The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In certain embodiments, the circulating protein mediates a disease and/or disorder in a subject, and treatment or management of the disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein in the subject. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the circulation concentration of the circulating protein, thus treating, ameliorating, or preventing the disease and/or disorder.

    INTEGRATED CIRCUIT WITH TOPOLOGICAL SEMIMETAL INTERCONNECTS
    8.
    发明申请
    INTEGRATED CIRCUIT WITH TOPOLOGICAL SEMIMETAL INTERCONNECTS 有权

    公开(公告)号：US20230030586A1

    公开(公告)日：2023-02-02

    申请号：US17813395

    申请日：2022-07-19

    申请人： YALE UNIVERSITY

    发明人： HyeukJin Han ,  Jeeyoung Cha

    IPC分类号： H01L23/532 ,  H01L23/528 ,  C23C16/30 ,  C30B25/02 ,  C30B29/14

    摘要： An integrated circuit comprises a first circuit element operably connected to a second circuit element by a nanowire interconnect; wherein the nanowire interconnect comprises molybdenum phosphide (MoP), tungsten phosphide (WP2), or niobium phosphide (NbP). A nanowire interconnect can be made by providing a template nanowire; providing a phosphine source; producing phosphine from the phosphine source; and contacting the template nanowire with the phosphine. The nanowire interconnect demonstrates low resistance.

    METHODS OF INDUCING OR ENHANCING FARNESOID X RECEPTOR (FXR)-MEDIATED TRANSCRIPTIONAL RESPONSE
    10.
    发明申请
    METHODS OF INDUCING OR ENHANCING FARNESOID X RECEPTOR (FXR)-MEDIATED TRANSCRIPTIONAL RESPONSE 有权

    公开(公告)号：US20220409631A1

    公开(公告)日：2022-12-29

    申请号：US17776922

    申请日：2020-11-19

    申请人： YALE UNIVERSITY

    发明人： YungChi Cheng ,  Wing Lam

    IPC分类号： A61K31/575 ,  A61K36/07

    摘要： The disclosure provides a method of treating disease or disorder in a subject in need thereof by administering a therapeutically effective amount of an extract comprising at least one selective Farnesoid X receptor (FXR) agonist obtained from Antrodia cinnamomea (Antrodia camphorate) to the subject. The disease or the disorder includes liver disease, obesity, diabetes, diarrhea, abdominal pain, hypertension, itchy skin, liver cancer, hepatitis, biliary cholangitis, nonalcoholic steatohepatitis, primary sclerosing cholangitis, inflammation, and fibrosis.