公开(公告)号：US09957293B2

公开(公告)日：2018-05-01

申请号：US13447825

申请日：2012-04-16

Applicant: Avigdor Scherz ,  Yoram Salomon ,  Efrat Rubinstein ,  Alexander Brandis ,  Doron Eren ,  Karin Neimann

Inventor： Avigdor Scherz ,  Yoram Salomon ,  Efrat Rubinstein ,  Alexander Brandis ,  Doron Eren ,  Karin Neimann

IPC: C07K5/12 ,  C07K5/09 ,  C07K5/10 ,  C07K7/06 ,  C07K7/64 ,  A61K41/00 ,  A61K51/08 ,  G01N33/574 ,  A61K47/64 ,  A61K51/00 ,  A61M36/14

CPC classification number: C07K5/123 ,  A61K41/00 ,  A61K41/0071 ,  A61K47/64 ,  A61K51/082 ,  A61K51/088 ,  C07K5/0817 ,  C07K5/10 ,  C07K5/126 ,  C07K7/06 ,  C07K7/64 ,  G01N33/57426 ,  G01N2333/96411

Abstract: Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.

公开(公告)号：US20140256789A1

公开(公告)日：2014-09-11

申请号：US14280822

申请日：2014-05-19

Applicant: Moshe Oren ,  Nina Raver-Shapira ,  Efi Marciano ,  Yael Spector

Inventor： Moshe Oren ,  Nina Raver-Shapira ,  Efi Marciano ,  Yael Spector

IPC: C12N15/113 ,  A61K45/06 ,  C12Q1/68 ,  A61K31/7105

CPC classification number: C12Q1/6886 ,  A61K31/7105 ,  A61K45/06 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.

Abstract translation: 本文描述了调节p53依赖性细胞死亡和细胞增殖的组合物和方法。 组合物是微小RNA和相关核酸。

公开(公告)号：US20110236948A1

公开(公告)日：2011-09-29

申请号：US13127358

申请日：2009-11-03

Applicant: Ron Naaman ,  Amos Bardea ,  Alexander Yoffe

Inventor： Ron Naaman ,  Amos Bardea ,  Alexander Yoffe

IPC: C12N13/00 ,  B05D1/32 ,  B01J37/34

CPC classification number: C12M23/06 ,  B81C1/00031 ,  B81C2201/0154 ,  B81C2201/0198 ,  C12M27/00 ,  H01F41/16

Abstract: The present invention relates to a method and apparatus for patterning a substrate. The method comprises providing at least one magnetic pattern generator configured and operable to modulate the magnetic field to induce varying magnetic properties to a magnetic field according to a desired pattern; applying the modulated magnetic field in the vicinity of the substrate creating a certain pattern of regions of interaction to be obtained on top of the substrate; and; interacting the substrate with magnetic particles, while under the application of the modulated magnetic field, the magnetic particles being attracted to selected regions of interaction defined by the certain pattern while being substantially not attracted to regions outside the regions of interaction, thus creating on top of the substrate the certain pattern of regions interacted with the magnetic particles. The desired pattern corresponds to a certain pattern for a predetermined magnetic field profile and at a predetermined distance from the magnetic pattern generator, where the sample is to be located.

Abstract translation: 本发明涉及一种用于图案化衬底的方法和装置。 该方法包括提供至少一个磁图案发生器，其被配置和可操作以根据期望的图案调制磁场以对磁场引起变化的磁特性; 将调制的磁场施加在衬底附近，产生在衬底的顶部上获得的相互作用区域的特定图案; 和; 在将基底与磁性颗粒相互作用的同时，在调制磁场的应用下，磁性颗粒被吸引到由特定图案定义的相互作用区域之间，同时基本上不被吸引到相互作用区域之外的区域，从而在 基板的某些图案区域与磁性颗粒相互作用。 期望的图案对应于预定磁场分布的特定图案，并且距离磁图案发生器预定距离处，其中样本将被定位。

公开(公告)号：US07933301B2

公开(公告)日：2011-04-26

申请号：US12457318

申请日：2009-06-08

Applicant: Amiel A. Ishaaya ,  Nir Davidson ,  Asher A. Friesem ,  Liran Shimshi

Inventor： Amiel A. Ishaaya ,  Nir Davidson ,  Asher A. Friesem ,  Liran Shimshi

IPC: H01S3/13 ,  H01S3/08

CPC classification number: H01S3/07 ,  H01S3/0805 ,  H01S3/08054 ,  H01S3/08059 ,  H01S3/08063 ,  H01S3/08068 ,  H01S3/0811 ,  H01S3/0816 ,  H01S3/082 ,  H01S3/10 ,  H01S3/10092 ,  H01S3/1106 ,  H01S3/1307 ,  H01S3/2383 ,  H01S5/4012 ,  H01S5/4025 ,  H01S5/4062

Abstract: A resonator cavity (10A) and method are provided. The resonator cavity (10A) includes at least one gain medium (16) and end reflectors (12, 14) which define together longitudinal modes of light in the cavity, and further includes an intra-cavity beam coupler assembly (20). The beam coupler assembly (20) is configured to split light impinging thereon into a predetermined number of spatially separated light channels, and to cause phase locking and at least partial coherent combining of the light channels, having common longitudinal and transverse modes, in a double pass through the beam coupler assembly (20). The resonator cavity (10A) is configured and operable to produce at least one output combined light channel of a predetermined intensity profile.

Abstract translation: 提供了谐振腔（10A）和方法。 谐振器腔（10A）包括至少一个增益介质（16）和端部反射器（12,14），所述增益介质和端部反射器（12,14）一起限定空腔中的纵向光模式，并且还包括腔内光束耦合器组件（20）。 光束耦合器组件（20）被配置成将入射到其上的光分解成预定数量的空间分离的光通道，并且使得具有共同的纵向和横向模式的光通道的相位锁定和至少部分相干组合在双 穿过光束耦合器组件（20）。 谐振器腔（10A）被配置和可操作以产生具有预定强度分布的至少一个输出组合光通道。

公开(公告)号：US20110033666A1

公开(公告)日：2011-02-10

申请号：US12988067

申请日：2009-04-07

Applicant: Israel Rubinstein ,  Alexander Vaskevich ,  Tatyana Karakouz

Inventor： Israel Rubinstein ,  Alexander Vaskevich ,  Tatyana Karakouz

IPC: B32B3/10 ,  B05D5/00

CPC classification number: G02B5/008 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  C03C17/006 ,  C03C2217/42 ,  C03C2218/151 ,  C03C2218/32 ,  C23C14/18 ,  C23C14/5806 ,  C23C14/5853 ,  G01N21/41 ,  G01N21/554

Abstract: A method is presented for use in fabrication of metal islands on an oxide substrate. The method comprises: depositing a selected metal on the oxide substrate by evaporation of said selected metal; and annealing a film of the selected metal on said substrate at temperatures including an annealing temperature being less than 50° C. lower than a glass transition temperature, thereby forming the metal islands partially embedded in said substrate.

Abstract translation: 提出了一种用于在氧化物衬底上制造金属岛的方法。 该方法包括：通过蒸发所述选择的金属将所选择的金属沉积在氧化物基底上; 以及在包括退火温度低于玻璃化转变温度的50℃的温度的温度下退火所述基板上的所选金属的膜，由此形成部分地嵌入所述基板中的金属岛。

公开(公告)号：US20100206298A1

公开(公告)日：2010-08-19

申请号：US12675517

申请日：2008-08-31

Applicant: Jacob Karni

Inventor： Jacob Karni

IPC: F24J2/24 ,  F24J2/46 ,  F24J2/00 ,  F03G6/06

CPC classification number: F03G6/06 ,  F24S20/20 ,  Y02E10/41 ,  Y02E10/46

Abstract: A solar receiver is disclosed and includes a housing having a front, radiation-facing, end and a rear end, the front end being formed with a cavity therein. A window is mounted at the front end of the housing and projects inside the cavity. A receiver chamber is defined within the cavity between the housing and the window. The receiver chamber has a working fluid inlet for ingress of working fluid to be heated therewithin, and a working fluid outlet for egress therethrough of the heated fluid. A solar absorber is within the receiver chamber for absorbing the solar radiation and heating the working fluid. The solar absorber includes at least one tubular member configured for maintaining fluid isolation between contents thereof and contents of the receiver chamber. The solar absorber is configured for heating working fluid within the receiver chamber exterior to the tubular member, and working fluid within the tubular member.

Abstract translation: 公开了一种太阳能接收器，并且包括具有前部，面向辐射的端部和后端的壳体，前端在其中形成有空腔。 窗口安装在壳体的前端并在腔体内突出。 接收器室限定在壳体和窗口之间的空腔内。 接收器室具有工作流体入口，用于进入其中加热的工作流体，以及用于通过其加热的流体流出的工作流体出口。 接收器室内有一个太阳能吸收器，用于吸收太阳辐射并加热工作流体。 太阳能吸收器包括至少一个管状构件，其构造成用于保持其内容物与接收器室的内容物之间的流体隔离。 太阳能吸收器被配置用于加热管状构件外部的接收器室内的工作流体和管状构件内的工作流体。

公开(公告)号：US20100200044A1

公开(公告)日：2010-08-12

申请号：US12301399

申请日：2007-05-30

Applicant: Arie Zaban ,  David Cahen ,  Igor Lubomirsky ,  Oscar M. Stafsudd

Inventor： Arie Zaban ,  David Cahen ,  Igor Lubomirsky ,  Oscar M. Stafsudd

IPC: H01L31/052

CPC classification number: H01L31/0528 ,  H01L31/0547 ,  H01L31/0549 ,  Y02E10/52

Abstract: A solar energy conversion system is presented. The system comprises at least one waveguide arrangement having at least one light input respectively. The waveguide arrangement comprises a core unit for passing input solar radiation therethrough and a cladding material arrangement interfacing with the core therealong. The cladding material arrangement is configured as an array of spaced-apart solar cells arranged along the core unit and having different optical absorption ranges, such that an interface between the waveguide core and the cladding arrangement spectrally splits the photons of the input solar radiation by causing the photons of different wavelengths, while passing through the core unit, to be successively absorbed and thereby converted into electricity by the successive solar cells of said array.

Abstract translation: 提出了太阳能转换系统。 该系统包括分别具有至少一个光输入的至少一个波导装置。 波导装置包括用于使输入的太阳辐射通过的芯单元和与其相连接的包层材料布置。 包层材料布置被配置为沿着芯单元布置并具有不同光吸收范围的间隔开的太阳能电池阵列，使得波导芯和包层布置之间的界面通过引起输入的太阳辐射光谱分裂光子 不同波长的光子在通过核心单元时被连续吸收，从而由所述阵列的连续太阳能电池转换成电。

公开(公告)号：US07704944B2

公开(公告)日：2010-04-27

申请号：US11505554

申请日：2006-08-16

Applicant: Daniela Novick ,  Charles Dinarello ,  Menachem Rubinstein ,  Soo Hyun Kim ,  Giamila Fantuzzi ,  Leonid L. Reznikov ,  Boris Schwartsburd

Inventor： Daniela Novick ,  Charles Dinarello ,  Menachem Rubinstein ,  Soo Hyun Kim ,  Giamila Fantuzzi ,  Leonid L. Reznikov ,  Boris Schwartsburd

IPC: A61K38/00

CPC classification number: A61K38/1793 ,  A61K38/00 ,  A61K38/21 ,  A61K39/395 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/7155 ,  C07K16/18 ,  C07K16/244 ,  C07K16/2866 ,  C07K2319/00 ,  A61K2300/00

Abstract: The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.

Abstract translation: 本发明提供一种治疗或预​​防脓毒病和其他系统性炎症反应综合征（SIRS）特征的疾病的方法，包括严重败血症，败血性休克和与心脏功能障碍有关的败血症。

公开(公告)号：US20090245295A1

公开(公告)日：2009-10-01

申请号：US12457318

申请日：2009-06-08

Applicant: Amiel A. Ishaaya ,  Nir Davidson ,  Asher A. Friesem ,  Liran Shimshi

Inventor： Amiel A. Ishaaya ,  Nir Davidson ,  Asher A. Friesem ,  Liran Shimshi

IPC: H01S3/098 ,  H01S3/08 ,  H01S3/10

CPC classification number: H01S3/07 ,  H01S3/0805 ,  H01S3/08054 ,  H01S3/08059 ,  H01S3/08063 ,  H01S3/08068 ,  H01S3/0811 ,  H01S3/0816 ,  H01S3/082 ,  H01S3/10 ,  H01S3/10092 ,  H01S3/1106 ,  H01S3/1307 ,  H01S3/2383 ,  H01S5/4012 ,  H01S5/4025 ,  H01S5/4062

Abstract: A resonator cavity (10A) and method are provided. The resonator cavity (10A) includes at least one gain medium (16) and end reflectors (12, 14) which define together longitudinal modes of light in the cavity, and further includes an intra-cavity beam coupler assembly (20). The beam coupler assembly (20) is configured to split light impinging thereon into a predetermined number of spatially separated light channels, and to cause phase locking and at least partial coherent combining of the light channels, having common longitudinal and transverse modes, in a double pass through the beam coupler assembly (20). The resonator cavity (10A) is configured and operable to produce at least one output combined light channel of a predetermined intensity profile.

Abstract translation: 提供了谐振腔（10A）和方法。 谐振器腔（10A）包括至少一个增益介质（16）和端部反射器（12,14），所述增益介质和端部反射器（12,14）一起限定空腔中的纵向光模式，并且还包括腔内光束耦合器组件（20）。 光束耦合器组件（20）被配置成将入射到其上的光分解成预定数量的空间分离的光通道，并且使得具有共同的纵向和横向模式的光通道的相位锁定和至少部分相干组合在双 穿过光束耦合器组件（20）。 谐振器腔（10A）被配置和可操作以产生具有预定强度分布的至少一个输出组合光通道。

公开(公告)号：US07555024B2

公开(公告)日：2009-06-30

申请号：US10583125

申请日：2004-12-16

Applicant: Amiel A. Ishaaya ,  Nir Davidson ,  Asher A. Friesem ,  Liran Shimshi

Inventor： Amiel A. Ishaaya ,  Nir Davidson ,  Asher A. Friesem ,  Liran Shimshi

IPC: H01S3/13 ,  H01S3/08

CPC classification number: H01S3/07 ,  H01S3/0805 ,  H01S3/08054 ,  H01S3/08059 ,  H01S3/08063 ,  H01S3/08068 ,  H01S3/0811 ,  H01S3/0816 ,  H01S3/082 ,  H01S3/10 ,  H01S3/10092 ,  H01S3/1106 ,  H01S3/1307 ,  H01S3/2383 ,  H01S5/4012 ,  H01S5/4025 ,  H01S5/4062

Abstract: A resonator cavity (10A) and method and presented. The resonator cavity (10A) comprises at least one gain medium (16) and end reflectors (12, 14) which define together longitudinal modes of light in the cavity, and further comprises an intra-cavity beam coupler assembly (20). The beam coupler assembly (20) is configured to split light impinging thereon into a predetermined number of spatially separated light channels, and to cause phase locking and at least partial coherent combining of the light channels, having common longitudinal and transverse modes, in a double pass through the beam coupler assembly (20). The resonator cavity (10A) is configured and operable to produce at least one output combined light channel of a predetermined intensity profile.

Abstract translation: 一种谐振腔（10A）及其方法。 谐振器腔（10A）包括至少一个增益介质（16）和端部反射器（12,14），端部反射器（12,14）将空腔中的纵向光模式定义在一起，并且还包括腔内光束耦合器组件（20）。 光束耦合器组件（20）被配置成将入射到其上的光分解成预定数量的空间分离的光通道，并且使得具有共同的纵向和横向模式的光通道的相位锁定和至少部分相干组合在双 穿过光束耦合器组件（20）。 谐振器腔（10A）被配置和可操作以产生具有预定强度分布的至少一个输出组合光通道。