公开(公告)号：US20230346324A1

公开(公告)日：2023-11-02

申请号：US18342207

申请日：2023-06-27

Applicant: The General Hospital Corporation

Inventor： Nathaniel Alpert ,  Georges El Fakhri

IPC: A61B6/03 ,  A61B6/00 ,  A61B5/0275 ,  A61K51/04 ,  A61B5/00

CPC classification number: A61B6/037 ,  A61B6/481 ,  A61B5/02755 ,  A61B6/508 ,  A61B6/507 ,  A61B6/503 ,  A61K51/0459 ,  A61B5/4884

Abstract: The present invention provides a system and method for performing a single-scan rest-stress cardiac measurement. In one aspect, the system includes a positron emission tomography (PET) imaging system, a source of a first PET radiotracer for administration to a subject, a source of a second PET radiotracer for administration to a subject, and a processor. The processor has non-transient computer readable media programmed with instructions to obtain PET images of the subject administered with the radiotracer. Furthermore, the computer readable media is programmed with instructions to process the PET images with a non-steady-state, multi-compartment parametric model. An output of the non-steady-state, multi-compartment parametric model is a measure of myocardial blood flow for both a rest state and a stress state of the subject.

公开(公告)号：US09460509B2

公开(公告)日：2016-10-04

申请号：US14680201

申请日：2015-04-07

Applicant: Toshiba Medical Systems Corporation

Inventor： Shintaro Funabasama

IPC: G06K9/00 ,  G06T7/00 ,  A61B5/055 ,  A61B6/03 ,  A61B6/00 ,  G01R33/56 ,  G01R33/563 ,  A61B5/026 ,  A61B5/0275

CPC classification number: G06T7/0016 ,  A61B5/0263 ,  A61B5/0275 ,  A61B5/02755 ,  A61B5/055 ,  A61B6/032 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5205 ,  G01R33/5608 ,  G01R33/56366 ,  G06F19/00 ,  G06T2207/10072 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/30104

Abstract: In an image processing apparatus according to an embodiment, a noise information obtaining unit obtains information about an obstructive factor that is related to the precision level of perfusion images and is contained in pieces of medical image data acquired chronologically; on the basis of a TDC at an inflow blood vessel for an analysis target tissue of which the perfusion state is analyzed and on the basis of a perfusion model of the analysis target tissue, an estimating unit estimates a TDC of the analysis target tissue; on the basis of the estimated TDC of the analysis target tissue and on the basis of the information about the obstructive factor, a generating unit generates assessment information used for assessing reliability of the perfusion images generated from the pieces of medical image data; and a display control unit exercises control so that a display unit displays the assessment information.

Abstract translation: 在根据实施例的图像处理装置中，噪声信息获取单元获得与灌注图像的精度水平相关的阻塞因子的信息，并且包含在按时间顺序获取的医学图像数据中; 基于分析用灌注状态的分析对象组织的流入血管的TDC，基于分析对象组织的灌注模型，估计单元估计分析对象组织的TDC; 基于所述分析对象组织的估计TDC，基于所述阻塞因子的信息，生成单元生成用于评估从所述医疗图像数据生成的灌注图像的可靠性的评价信息; 并且显示控制单元进行控制，使得显示单元显示评估信息。

公开(公告)号：US09002656B2

公开(公告)日：2015-04-07

申请号：US13275041

申请日：2011-10-17

Applicant: Joseph Feldschuh ,  Jonathan Feldschuh

Inventor： Joseph Feldschuh ,  Jonathan Feldschuh

IPC: G06F19/10 ,  G01D18/00 ,  A61B6/00 ,  A61B5/0275 ,  A61B5/145 ,  A61B5/155

CPC classification number: A61B5/02755 ,  A61B5/1427 ,  A61B5/14546 ,  A61B5/15003 ,  A61B5/155 ,  A61B5/157 ,  G01N33/6827 ,  G01N2333/76 ,  G06F19/00 ,  G06F19/10

Abstract: A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.

Abstract translation: 一种基于计算机的方法，用于基于计算出的血管内白蛋白自动测定生物体总白蛋白，计算的血管内系统中白蛋白量与第一次血管外系统中白蛋白量的观察比例以及基线 血管内系统中白蛋白量与首次血管外系统白蛋白量的预期比例。

公开(公告)号：US20120245460A1

公开(公告)日：2012-09-27

申请号：US13513821

申请日：2010-12-03

Applicant: Piotr J. Slomka ,  Daniel S. Berman ,  Guido Germano

Inventor： Piotr J. Slomka ,  Daniel S. Berman ,  Guido Germano

IPC: A61B5/02 ,  A61B5/0402 ,  A61B6/00

CPC classification number: A61B5/02755 ,  A61B5/0402 ,  A61B5/4884 ,  A61B6/037 ,  A61B6/503 ,  A61B6/507 ,  A61B6/5217 ,  G06T7/001 ,  G06T2207/10108 ,  G06T2207/30048

Abstract: A method of identifying perfusion abnormalities in a heart of a patient. The method is performed with a patient stress map including stress values, a patient rest map including rest values, and one or more normal maps. The normal maps may include a normal change limit map including change limits, and a normal stress limit map including stress limits. The stress and rest maps are co-registered with one another and the normal maps. The method includes creating a patient change map by subtracting the rest count values of the rest map from the stress count values of the co-registered stress map. Then, in some embodiments, the patient stress and change maps are jointly compared to the normal stress and change limit maps to detect one or more hypoperfused regions. In such embodiments, the one or more regions detected are identified as having perfusion abnormalities and optionally displayed.

Abstract translation: 一种识别患者心脏灌注异常的方法。 该方法使用包括应力值的患者应力图，包括休息值的患者休息图和一个或多个法线贴图进行。 法线贴图可以包括包括变化极限的正常变化极限图，以及包括应力极限的正常应力极限图。 压力和休息地图彼此共同登记和正常地图。 该方法包括通过从共同注册的应力图的应力计数值中减去其余图的其余计数值来创建患者变化图。 然后，在一些实施例中，患者压力和变化图与正常应力和变化极限图共同比较，以检测一个或多个低灌注区域。 在这样的实施例中，检测到的一个或多个区域被识别为具有灌注异常并且可选地显示。

公开(公告)号：US20110104067A1

公开(公告)日：2011-05-05

申请号：US12987313

申请日：2011-01-10

Applicant: Bastiaan Driehuys ,  Margaret Hall ,  Claudio Marelli ,  Sven Mansson ,  Jan Wolber

Inventor： Bastiaan Driehuys ,  Margaret Hall ,  Claudio Marelli ,  Sven Mansson ,  Jan Wolber

IPC: A61B5/055

CPC classification number: A61K49/06 ,  A61B5/02755 ,  A61B5/055 ,  A61B5/0813 ,  A61B5/411 ,  A61B5/413 ,  G01N24/08 ,  G01R33/46 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/56308

Abstract: In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.

Abstract translation: 在某些实施方案中，本发明的方法获得在所选结构，环境或系统中的极化129Xe的NMR光谱信号的动态数据集。 信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。 因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。

公开(公告)号：US20100063384A1

公开(公告)日：2010-03-11

申请号：US12312504

申请日：2007-11-14

Applicant: Giora Kornblau ,  David M. Neustadter ,  Tal Shchory ,  Saul Stokar

Inventor： Giora Kornblau ,  David M. Neustadter ,  Tal Shchory ,  Saul Stokar

IPC: A61B5/0275 ,  A61B5/06 ,  A61M37/00

CPC classification number: A61B5/073 ,  A61B1/00156 ,  A61B5/02755 ,  A61B5/065 ,  A61B6/4057 ,  A61B6/507 ,  A61B2090/392 ,  A61M31/007

Abstract: A system for delivery of a capsule to a target location within a subject body including a capsule including a locomotion element and a gamma emitting radioactive source, a radiation tracking subsystem capable of locating the gamma emitting radioactive source in three dimensions, and a locomotion control subsystem capable of controlling movement of the capsule by effecting movement of the locomotion element, based, at least partly, on a location of the gamma emitting radioactive source provided by the radiation tracking subsystem. A method of measuring a velocity of flow of a fluid at a target location within a subject body including inserting a capsule including a locomotion element and a gamma emitting radioactive source into the body, using a radiation tracking subsystem to locate the gamma emitting radioactive source in three dimensions, moving the capsule to the target location within the body using a locomotion control subsystem which controls movement of the capsule by effecting movement of the locomotion element, based, at least partly, on location of the gamma emitting radioactive source provided by the radiation tracking subsystem, and measuring the velocity of flow of the fluid at the target location. Related apparatus and methods are also described.

Abstract translation: 一种用于将胶囊输送到包括运动元件和伽马射线放射源的胶囊的主体内的目标位置的系统，能够在三维位置定位伽马射线放射源的辐射跟踪子系统，以及运动控制子系统 能够通过至少部分地基于由辐射跟踪子系统提供的伽马发射放射源的位置来实现运动元件的运动来控制胶囊的移动。 一种测量目标体内目标位置处的流体流速的方法，包括使用辐射跟踪子系统将包含运动元件和伽马射线放射源的胶囊插入体内，以将伽马射线放射源定位在 使用运动控制子系统将胶囊移动到身体内的目标位置，运动控制子系统至少部分地基于由放射线提供的伽马射线放射源的位置来实现运动元件的运动来控制胶囊的移动 跟踪子系统，并测量目标位置处流体的流速。 还描述了相关装置和方法。

公开(公告)号：US20090190807A1

公开(公告)日：2009-07-30

申请号：US11988926

申请日：2006-07-19

Applicant: Benny Rousso ,  Eli Dichterman ,  Omer Ziv ,  Shlomo Ben-Haim

Inventor： Benny Rousso ,  Eli Dichterman ,  Omer Ziv ,  Shlomo Ben-Haim

IPC: G06K9/00

CPC classification number: A61K51/02 ,  A61B5/02755 ,  A61B5/06 ,  A61B5/415 ,  A61B5/418 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0476 ,  A61K51/0478 ,  A61K51/048 ,  A61K51/0489 ,  A61K51/0491 ,  A61K51/1203

Abstract: A method for stabilizing the reconstruction of an imaged volume is presented. The method includes the steps of performing an analysis of the reliability of reconstruction of a radioactive-emission density distribution of the volume from radiation detected over a specified set of views, and defining modifications to the reconstruction process and/or data collection process to improve the reliability of reconstruction, in accordance with the analysis.

Abstract translation: 呈现稳定成像体重建的方法。 该方法包括以下步骤：对在特定视图中检测到的放射线对体积的放射性发射密度分布进行重建的可靠性进行分析，并且对重建过程和/或数据收集过程进行修改以改进 可靠性重建，按照分析。

公开(公告)号：US07409240B1

公开(公告)日：2008-08-05

申请号：US11054278

申请日：2005-02-09

Applicant: Harry A. Bishop

Inventor： Harry A. Bishop

IPC: A61B6/00

CPC classification number: G01T1/1644 ,  A61B5/02755 ,  A61B6/4258 ,  A61B6/503 ,  A61B6/507

Abstract: One aspect of the present invention relates to imaging a patient to determine whether he or she has suffered a myocardial infarction. According to this method, a patient is injected with a bolus having a radioactive tracer. A representative cycle is produced for both the right ventricular passage of the bolus and the left ventricular passage of the bolus based on planar coordinates over time of scintillation events of the tracer. A time activity curve based on activity in each segment of the respective representative cycles is generated. When a segment of heart muscle is damaged its contraction ceases or lags behind the normal surrounding myocardium resulting in a phase shift in the adjacent blood pool.

Abstract translation: 本发明的一个方面涉及对患者进行成像以确定他或她是否患有心肌梗死。 根据该方法，向患者注射具有放射性示踪剂的推注物。 针对示踪剂的闪烁事件随时间的平面坐标，产生针对推注的右心室通道和推注的左心室通道的代表性循环。 产生基于相应代表循环的每个段中的活动的时间活动曲线。 当一段心肌受损时，其收缩停止或滞后于正常周围的心肌，导致相邻血液池相移。

公开(公告)号：US20080033291A1

公开(公告)日：2008-02-07

申请号：US11794799

申请日：2006-01-15

Applicant: Benny Rousso ,  Dalia Dickman ,  Michael Nagler ,  Shankar Vallabhajosula

Inventor： Benny Rousso ,  Dalia Dickman ,  Michael Nagler ,  Shankar Vallabhajosula

IPC: A61B6/03

CPC classification number: A61B5/02755 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4519 ,  A61B5/7203 ,  A61B5/7264 ,  A61B6/037 ,  A61B6/486 ,  A61B6/507 ,  G01T1/1647

Abstract: The present invention relates to the capabilities of a highly sensitive radioactive-emission camera, a result of a meticulous search for the many different effects that combine synergistically to increase sensitivity and spatial, spectral, and time resolutions. The new camera opens a new realm in SPECT-type imaging, making it viable for dynamic studies, the use of radiopharmaceutical cocktails, molecular imaging, dosimetry and other studies requiring the high sensitivity and resolutions. In particular, the new camera opens the door to SPECT expert system, examples for which are provided. The expert system relates to defining disease signatures for automatic diagnosis, preferably, based on a multi-parameter vector, preferably, based on kinetic radiopharmaceutical values. Additionally or alternatively, based on simultaneous administration of multiple isotopes.

Abstract translation: 本发明涉及高灵敏度的放射性发射照相机的能力，这是精心搜索协同增加灵敏度和空间，光谱和时间分辨率的许多不同效果的结果。 新相机打开了SPECT型成像领域的新领域，使其成为动态研究，使用放射性药物鸡尾酒，分子成像，剂量学和其他需要高灵敏度和分辨率的研究。 特别是，新相机打开了SPECT专家系统的大门，为其提供了实例。 专家系统关于定义用于自动诊断的疾病特征，优选地，基于多参数向量，优选地基于动力学放射性药物值。 另外或替代地，基于同时施用多个同位素。

公开(公告)号：US20040005273A1

公开(公告)日：2004-01-08

申请号：US10356240

申请日：2003-01-31

Inventor： Bastiaan Driehuys ,  Margaret Hall ,  Claudio Marelli ,  Sven Mansson ,  Jan Wolber

IPC: A61K049/00

CPC classification number: A61K49/06 ,  A61B5/02755 ,  A61B5/055 ,  A61B5/0813 ,  A61B5/411 ,  A61B5/413 ,  G01N24/08 ,  G01R33/46 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/56308

Abstract: In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.

Abstract translation: 在某些实施方案中，本发明的方法获得在所选结构，环境或体系中的极化X射线荧光信号的动态数据集。 信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。 因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。