公开(公告)号：US20150023873A1

公开(公告)日：2015-01-22

申请号：US14357555

申请日：2012-10-31

申请人： Lantheus Medical Imaging, Inc. ,  Yale University

发明人： Albert J. Sinusas ,  Joseph G. Akar ,  Richard R. Cesati ,  Heike S. Radeke ,  Stephen B. Haber

IPC分类号： A61K51/04 ,  A61K51/08

CPC分类号： A61K51/044 ,  A61B2576/023 ,  A61K51/0459 ,  A61K51/0476 ,  A61K51/0478 ,  A61K51/0497 ,  A61K51/08

摘要： The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.

摘要翻译： 在一些实施方案中，本发明提供了与评估增加的心房颤动（AF）的风险相关的方法和/或使用包含与成像部分连接的MMP抑制剂的成像剂对特定AF治疗作出响应的可能性。 本发明进一步提供了通过测定MMP水平来评估是否存在发展其他心血管疾病的风险的方法以及评估治疗或其他介入治疗或其他干预措施的有效性的方法。

公开(公告)号：US20140193336A1

公开(公告)日：2014-07-10

申请号：US14147682

申请日：2014-01-06

申请人： Biosensors International Group, Ltd.

发明人： Benny ROUSSO ,  Dalia Dickman ,  Yael Nir ,  Michael Nagler ,  Zohar Bronshtine ,  Shankar Vallabhajosula ,  Shlomo Ben-Haim ,  Simona Ben-Haim

IPC分类号： A61K51/04

CPC分类号： A61K51/0476 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/503 ,  G01T1/1644

摘要： Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

摘要翻译： 提供用于放射成像事件或障碍的协议。 示例性方案包括放射成像心肌灌注的方法，该方法依次包括：（a）向受试者施用约3mCi Tl201硫酸氯化物; （b）允许所述受试者休息; （c）对所述受试者的心脏进行放射成像; （d）使所述受试者受到身体压力; （e）在所述身体应激的峰值处施用约20-30mCi Tc99m sestamibi的所述受试者; 和（f）对所述受试者的所述心脏进行放射成像，从而放射成像心肌灌注。

公开(公告)号：US20120077967A1

公开(公告)日：2012-03-29

申请号：US13232255

申请日：2011-09-14

申请人： RAJIV BHALLA

发明人： RAJIV BHALLA

IPC分类号： C07F13/00 ,  C07D401/14

CPC分类号： C07F13/00 ,  A61K51/0476

摘要： Novel radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(I) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhenium complexes of the invention are also provided, as well as radiopharmaceutical compositions comprising said complexes, kits for their preparation. The invention also relates to the use of 99mTc radiopharmaceuticals of the invention for SPECT imaging.

摘要翻译： 本发明提供了包含三配位配体的新型放射性锝和铼络合物。 特别地，本发明提供了Tc（I）配合物。 还提供了适合于形成本发明的锝和铼络合物的新配体，以及包含所述复合物的放射性药物组合物，用于其制备的试剂盒。 本发明还涉及本发明的99m Tc放射性药物用于SPECT成像的用途。

公开(公告)号：US08111886B2

公开(公告)日：2012-02-07

申请号：US11988926

申请日：2006-07-19

申请人： Benny Rousso ,  Eli Dichterman ,  Omer Ziv ,  Shlomo Ben-Haim

发明人： Benny Rousso ,  Eli Dichterman ,  Omer Ziv ,  Shlomo Ben-Haim

IPC分类号： G06K9/00

CPC分类号： A61K51/02 ,  A61B5/02755 ,  A61B5/06 ,  A61B5/415 ,  A61B5/418 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0476 ,  A61K51/0478 ,  A61K51/048 ,  A61K51/0489 ,  A61K51/0491 ,  A61K51/1203

摘要： A method for stabilizing the reconstruction of an imaged volume is presented. The method includes the steps of performing an analysis of the reliability of reconstruction of a radioactive-emission density distribution of the volume from radiation detected over a specified set of views, and defining modifications to the reconstruction process and/or data collection process to improve the reliability of reconstruction, in accordance with the analysis.

摘要翻译： 呈现稳定成像体重建的方法。 该方法包括以下步骤：对在特定视图中检测到的放射线对体积的放射性发射密度分布进行重建的可靠性进行分析，并且对重建过程和/或数据收集过程进行修改以改进 可靠性重建，按照分析。

公开(公告)号：US20070071672A1

公开(公告)日：2007-03-29

申请号：US10576839

申请日：2004-10-20

申请人： Roger Alberto ,  Fabio Zobi

发明人： Roger Alberto ,  Fabio Zobi

IPC分类号： A61K51/00

CPC分类号： A61K51/0476 ,  A61K33/24 ,  A61K51/0478

摘要： The invention relates to the use of metal tricarbonyl compounds of the general formula [M(CO),L,]′, wherein M is rhenium or technetium or an isotope thereof and L is a ligand, for the preparation of a medicament for the treatment of cancer that is both radiotherapeutic and chemotoxic when a radioactive metal is used and chemotoxic when cold rhenium or macroscopic amounts of long-lived Tc-99 is used. The medicament is in particular chemotoxic by causing intrastrand linkages in DNA. In a specific embodiment at least one of L is not OH2. The invention further relates to novel compounds of the general formula IM(CO)3XIX2X3]+ and their use, wherein M is rhenium or technetium or an isotope thereof and at least one X1. X2 and X3 is a monodentate ligand; or two of X, X2 and X3 are part of a bidentate ligand and the other one is optionally a monodentate ligand.

摘要翻译： 本发明涉及通式[M（CO），L，]'的金属三羰基化合物的用途，其中M是铼或锝或其同位素，L是配体，用于制备治疗药物 当放射性金属被使用时既放射治疗又具有化学毒性，并且当使用冷铼或宏观量的长寿命Tc-99时具有化学毒性。 该药物特别是通过在DNA中引起链内连锁的化学毒性。 在具体实施方案中，L中的至少一个不是OH 2。 本发明还涉及通式为IM（CO）3 XIX 2 X 3] +的新型化合物及其用途，其中M为铼或锝或其同位素和至少一种X1。 X2和X3是单齿配体; X，X 2和X 3中的两个是二齿配体的一部分，另一个是任选的单齿配体。

公开(公告)号：US20060160157A1

公开(公告)日：2006-07-20

申请号：US11334845

申请日：2006-01-19

申请人： Mathew Zuckerman

发明人： Mathew Zuckerman

IPC分类号： G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30 ,  C07K16/46 ,  A61K51/00

CPC分类号： G01N33/57488 ,  A61K51/0476 ,  C07K14/475 ,  C07K14/52 ,  C07K14/71 ,  C07K14/715 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2500/00

摘要： The present invention is directed towards classifying tumor biomarkers, particularly membrane receptors, and more particularly the gastrin-releasing peptide (GPR) receptors, identified in patient samples, then linking therapeutic agents (chemical, radiological, or biological) to patient-specific ligands that bind to such receptors, clinicians can produce diagnostic and treatment compositions and implement treatment regimens which, by using the classified and identified biomarkers, and due to their improved accuracy, increase success and decrease undesired side effects from such treatments.

公开(公告)号：US06825204B2

公开(公告)日：2004-11-30

申请号：US10358835

申请日：2003-02-05

申请人： Shuang Liu

发明人： Shuang Liu

IPC分类号： A61K3144

CPC分类号： C07D213/89 ,  A61K51/0476 ,  C07B2200/05 ,  C07D401/12 ,  C07D409/12

摘要： N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted 3-hydroxy-4-pyridinones and/or their metal chelates. Use of N-substituted 3-hydroxy-4-pyridinones and their metal chelates as pharmaceutical agents for the treatment of diseases, such as parasitic and viral infections, conditions associated with inflammation and infection, and conditions mediated by cell-proliferation or collagen formation.

摘要翻译： N-取代的3-羟基-4-吡啶酮和金属螯合物，N-取代的3-羟基-4-吡啶酮和金属螯合物的制备方法，以及含有新的N-取代的3-羟基-4-吡啶酮和/或它们的N- 金属螯合物。 N-取代的3-羟基-4-吡啶酮及其金属螯合物作为用于治疗疾病如寄生虫病毒和病毒感染，与炎症和感染相关的疾病以及由细胞增殖或胶原形成介导的病症的药物的用途。

公开(公告)号：US20040030248A1

公开(公告)日：2004-02-12

申请号：US10391525

申请日：2003-03-19

申请人： Cytyc Health Corporation

发明人： David Hung

IPC分类号： A61B006/00

CPC分类号： A61K51/0476 ,  A61B6/4258 ,  A61K51/04

摘要： The present invention relates to an apparatus and method for administering a radioactive tracer dye and an inhibitor compound into a breast duct of the breast and imaging the breast for breast lesions. The radioactive tracer dye may be Tc-99m sestamibi and the inhibitor compound may inhibit a P-glycoprotein pump in tumor cells. When the inhibitor compound inhibits the P-glycoprotein pump in tumor cells, the radioactive tracer dye may effectively accumulate in tumor cells and improve the sensitivity of nuclear imaging of breast lesions.

摘要翻译： 本发明涉及将放射性示踪剂染料和抑制剂化合物施用到乳房的乳房导管中并对乳房成像乳房病变的装置和方法。 放射性示踪剂染料可以是Tc-99m塞斯马司，抑制剂化合物可以抑制肿瘤细胞中的P-糖蛋白泵。 当抑制剂化合物抑制肿瘤细胞中的P-糖蛋白泵时，放射性示踪染料可有效积累在肿瘤细胞中，提高乳腺病变核成像的敏感性。

公开(公告)号：US20030228255A1

公开(公告)日：2003-12-11

申请号：US10287133

申请日：2002-10-31

发明人： Kyung Bae Park ,  Sang Hyun Park ,  Hui Jeong Gwon ,  Sun Ju Choi ,  Byung Chul Shin ,  Young Don Hong ,  Sang Mu Choi ,  Woong Woo Park ,  Kwang Hee Han ,  Beom Su Jang

IPC分类号： A61K051/00 ,  C07K016/46 ,  C07F013/00

CPC分类号： C07F13/005 ,  A61K51/0402 ,  A61K51/0476 ,  A61K51/0489

摘要： The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER) . The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2null14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.

摘要翻译： 本发明涉及在还原剂存在下，通过高锝酸盐或高铼酸盐与配体的反应制备放射性药物的锝或铼络合物的方法，其中还原剂是硼氢化物交换树脂（BER）。 本发明的硼氢化物交换树脂具有在广泛的Ph范围内稳定的优点，包括酸性或碱性条件（Ph 2〜14），因此适用于生物材料，并且在施用时易于通过过滤除去。 此外，由于放射性标记的复合物在比常规还原剂所需的条件更温和的条件下生产，并且具有高放射化学纯度和高标记效率，所以常规的还原剂可以被本发明的BER代替。

公开(公告)号：US20030068271A1

公开(公告)日：2003-04-10

申请号：US10153879

申请日：2002-05-24

发明人： John F. Valliant ,  Pierre Morel ,  Paul Schaffer ,  Oyebola O. Sogbein

IPC分类号： A61K051/00 ,  C07F013/00

CPC分类号： C07F13/005 ,  A61K51/0476

摘要： The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula nullM(CO)3(Xm)3null(1null3m), wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula nullnido-(C2B9H11)null2null and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.

摘要翻译： 本发明涉及一种基于锝和铼制备放射性药物的新方法。 该方法涉及式[M（CO）3（X））3] <（1 + 3m）>的盐的反应，其中M选自铼的放射性同位素，锝和任何其它结合的放射性同位素 以类似的方式，X是任何合适的配体，m是配体X的正式电荷，具有式[Nido - （C 2 B 9 H 11）] 2 2-的二 - 二碳二酰二胺和其官能衍生物。 该方法已被证明适用于示踪剂级放射性药物的制备。