公开(公告)号：US20180353748A1

公开(公告)日：2018-12-13

申请号：US15747599

申请日：2016-07-25

申请人： University Of Cincinnati ,  Eccrine Systems, Inc.

发明人： Jason C. Heikenfeld ,  Andrew Jajack ,  Elizabeth Sheetz

IPC分类号： A61N1/04 ,  A61N1/36 ,  A61B5/145

CPC分类号： A61N1/0444 ,  A61B5/14514 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/14546 ,  A61N1/36031

摘要： A device for sensing biofluid placed on skin with at least one pre-existing pathway includes a first analyte-specific sensor for sensing a first analyte in the biofluid and a volume-reduced pathway between skin and the first analyte-specific sensor configured to allow an advective flow of the biofluid from the at least one pre-existing pathway toward the first analyte-specific sensor. The first analyte-specific sensor does not consume the first analyte. The device further includes an iontophoresis electrode and a counter electrode for bringing the first analyte into the at least one pre-existing pathway. The biofluid may be more than 50% interstitial fluid or more than 50% sweat. The device may also include at least one of a wicking collector, a wicking coupler, or a wicking pump.

公开(公告)号：US20110092881A1

公开(公告)日：2011-04-21

申请号：US12903924

申请日：2010-10-13

申请人： Emma Amelia Durand ,  Michael K. Jordan

发明人： Emma Amelia Durand ,  Michael K. Jordan

IPC分类号： A61N1/30

CPC分类号： A61N1/0428 ,  A61K9/0009 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/325

摘要： The present application discloses an iontophoretic device with a contact electrode for detecting placement of the device and/or characteristics of the wearer's tissue.

摘要翻译： 本申请公开了一种具有用于检测装置的放置和/或穿着者组织的特征的接触电极的离子电渗疗法装置。

公开(公告)号：US07925520B2

公开(公告)日：2011-04-12

申请号：US12015449

申请日：2008-01-16

申请人： Kentaro Kogure ,  Kaoru Kigasawa ,  Naoki Nakamura

发明人： Kentaro Kogure ,  Kaoru Kigasawa ,  Naoki Nakamura

IPC分类号： A61M31/00 ,  G06Q10/00

CPC分类号： A61N1/0428 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/325 ,  G06F19/00 ,  G06Q50/22

摘要： A migration M of a drug ion in a membrane type iontophoresis device for administering the drug ion through a first ion exchange membrane is predicted on the basis of a migration C of the drug ion from the first ion exchange membrane to the outside of the device in the case where a voltage is applied to an electrode by using the device under such a condition that the first ion exchange membrane is not brought into contact with the skin of a living organism and a migration R of the drug ion to a liposome caused by mixing a liposome solution having a predetermined concentration and a drug solution containing a predetermined concentration of the drug ion.

摘要翻译： 基于从第一离子交换膜向装置外部的药物离子的迁移C，预测用于通过第一离子交换膜施用药物离子的膜型离子电渗疗装置中的药物离子的迁移M 在第一离子交换膜不与活体的皮肤接触的状态下，通过使用该装置向电极施加电压的情况以及由混合引起的药物离子向脂质体的迁移R 具有预定浓度的脂质体溶液和含有预定浓度的药物离子的药物溶液。

公开(公告)号：US20110021972A1

公开(公告)日：2011-01-27

申请号：US12895934

申请日：2010-10-01

申请人： Hirotoshi Adachi ,  Noriyuki Kuzumaki ,  Tetsuya Arimoto ,  Naruhito Higo

发明人： Hirotoshi Adachi ,  Noriyuki Kuzumaki ,  Tetsuya Arimoto ,  Naruhito Higo

IPC分类号： A61N1/30 ,  A61K31/4468 ,  A61K31/167 ,  A61K31/495 ,  A61P25/04 ,  A61P9/06

CPC分类号： A61N1/0448 ,  A61K9/0009 ,  A61K9/0014 ,  A61K47/32 ,  A61N1/0444

摘要： Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.

摘要翻译： 用于离子电渗的装置结构100提供电极101和导电层102.导电层102含有活性成分D和碱性水溶胀甲基丙烯酸酯共聚物P1和/或酸性水溶胀甲基丙烯酸酯共聚物P2。 将电极101和导电层102放置在背衬103的中空部分中，并且电极端子104通过背衬103连接到电极101.粘合层105设置在背衬103周围，并且在使用该装置时将衬垫106放置 以覆盖背衬103的中空部分。

公开(公告)号：US20100130912A1

公开(公告)日：2010-05-27

申请号：US12459186

申请日：2009-06-25

申请人： Ronald J. Berenson

发明人： Ronald J. Berenson

IPC分类号： A61N1/30

CPC分类号： A61K9/703 ,  A61K9/0009 ,  A61K9/0021 ,  A61K9/7023 ,  A61K31/295 ,  A61K33/26 ,  A61K38/1816 ,  A61K45/06 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/303 ,  A61K2300/00

摘要： Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.

摘要翻译： 本发明的实施方案提供了将含铁组合物透皮递送给患有铁缺乏症的个体的补片。 许多实施方案提供用于透皮递送治疗有效量的铁的离子电渗贴剂。 贴剂包括电极和含有用于递送治疗有效量的铁的包含离子铁的组合物的储存器。 各种实施方案提供使用离子电渗贴剂的实施方案的方法，用于将治疗有效量的铁递送至患有一种更多形式的铁缺乏症（包括缺铁性贫血）的个体。 这些方法可用于治疗和/或预防缺铁。 输送铁的量可以根据各种治疗参数（如患者体重，铁缺乏的类型和量）进行调整。

公开(公告)号：US07720622B2

公开(公告)日：2010-05-18

申请号：US11850602

申请日：2007-09-05

申请人： Gregory A. Smith

发明人： Gregory A. Smith

IPC分类号： G06F11/30

CPC分类号： A61N1/325 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/08

摘要： Systems, devices, and methods for evaluating iontophoresis devices. An impedance spectrometer is operable to determine an impedance of an iontophoresis device and a controller configured to perform a comparison of the measured impedance of the iontophoresis device to stored reference data, and to generate a response based in part on the comparison.

摘要翻译： 用于评估离子电渗装置的系统，装置和方法。 阻抗光谱仪可操作以确定离子电渗装置的阻抗和被配置为执行离子电渗装置的测量阻抗与存储的参考数据的比较的控制器，并且部分地基于比较来产生响应。

公开(公告)号：US20100100031A1

公开(公告)日：2010-04-22

申请号：US12643720

申请日：2009-12-21

申请人： Akihiko Tanioka ,  Mie Minegawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Mie Minegawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.

摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

公开(公告)号：US20090216175A1

公开(公告)日：2009-08-27

申请号：US11917733

申请日：2006-08-04

申请人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Matsumura ,  Kiyoshi Kanamura ,  Akihiko Tanioka

发明人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Matsumura ,  Kiyoshi Kanamura ,  Akihiko Tanioka

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/0428 ,  A61N1/0436 ,  A61N1/0448

摘要： To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.

摘要翻译： 提供能够增加药物转移到皮肤中的速度和要转移到皮肤中的药物的量的透皮给药装置。 透皮给药装置由以下部分构成：供给第一导电型电压的电极; 电解液保持部，其保持由所述电极通电的电解液; 以及放置在电解液保持部的前表面侧的双极性膜，其由选择性地通过第一导电类型的离子的第一离子交换膜和选择性地通过第一导电类型的离子的第二离子交换膜 第二导电类型。

公开(公告)号：US20080114282A1

公开(公告)日：2008-05-15

申请号：US11850600

申请日：2007-09-05

申请人： Darrick Carter

发明人： Darrick Carter

IPC分类号： A61N1/30

CPC分类号： A61N1/30 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/325

摘要： An iontophoresis device for providing transdermal delivery of one or more therapeutic active agents to a biological interface having an active electrode assembly, a counter electrode assembly, and an inductor electrically coupled to the active and the counter electrode assemblies. The inductor is operable to provide a voltage across at the active and the counter electrode elements in response to an applied varying electromagnetic field.

摘要翻译： 一种用于将一种或多种治疗活性剂透皮递送至具有活性电极组件，对电极组件和电耦合到活性和对电极组件的电感器的生物界面的离子电渗疗法装置。 电感器可操作以响应于施加的变化的电磁场在有源和对电极元件处提供一个电压。

公开(公告)号：US20070255195A1

公开(公告)日：2007-11-01

申请号：US11659908

申请日：2005-08-11

申请人： Hirotoshi Adachi

发明人： Hirotoshi Adachi

IPC分类号： A61N1/30

CPC分类号： A61N1/0448 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/30 ,  A61N1/325

摘要： An iontophoresis device which allows excellent transdermal absorption of an anionically chargeable physiologically active substance is provided. The iontophoresis device comprises a cathode (25) and an interface (31) or (32) composed of a cationically chargeable membrane, wherein an anionically chargeable physiologically active substance (drug) (10) is placed between the cathode (25) and the interface (31) or in the interface (32). A wall member (13) with an adhesive layer (12) in the bottom is placed around an absorbent (11), and a support (15) having an opening (14) in the center is placed on the absorbent (11) and the wall member (13). When the device is used, the dissolution liquid for the drug is supplied to the absorbent (11) through the opening (14). The absorbent (11) and the interface (31) or (32) become wet with the dissolution liquid and the drug (10) is activated uniformly.

摘要翻译： 提供了允许对阴离子可带电的生理活性物质进行极好的透皮吸收的离子电渗疗法装置。 离子电渗装置包括阴极（25）和由可阳离子电荷的膜构成的界面（31）或（32），其中阴极可带电的生理活性物质（药物）（10）被放置在阴极（25）和界面 （31）或接口（32）中。 在吸收体11的周围放置有在底部具有粘合剂层12的壁部件13，在吸收体11上设有具有中央部的开口部14的支承体15， 壁构件（13）。 当使用该装置时，用于药物的溶解液通过开口（14）供给到吸收剂（11）。 吸收剂（11）和界面（31）或（32）变得被溶解液弄湿，药物（10）被均匀地活化。