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1.发明授权公开(公告)号：US12065634B2
公开(公告)日：2024-08-20
申请号：US17871054
申请日：2022-07-22
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Daniel Levner , Guy Thompson, II , Jose Fernandez-Alcon , Christopher David Hinojosa
CPC classification number: C12M29/10 , B01L3/502715 , C12M21/08 , C12M23/16 , C12M23/38 , C12M23/58 , C12M29/00 , C12M29/20 , C12M37/04 , C12M41/48 , B01L3/0293 , B01L2200/027 , B01L2300/0816
Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.
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公开(公告)号：US12011714B2
公开(公告)日：2024-06-18
申请号：US16984955
申请日：2020-08-04
Applicant: Bio-Rad Laboratories, Inc. , Bio-Rad Europe GmbH
Inventor： Emilie Frisan , Laurent Guillon , Robert Lovchik , David P. Taylor , Claudia I. Trainito , Govind V. Kaigala
CPC classification number: B01L3/502707 , B01L3/0293 , B01L3/502761 , B01L2200/027 , B01L2200/0642 , B01L2200/0647 , B01L2400/0487
Abstract: The present disclosure is notably directed to a microfluidic probe head, or MFP head, comprising a processing surface having a liquid injection aperture and a liquid aspiration aperture thereon. The aspiration aperture is generally shaped so as to partly extend around the injection aperture on the processing surface, although such injection apertures are not completely surrounded by the slit on the processing surface. Further, fluidic and solid barriers to aspiration are considered. The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.
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公开(公告)号：US20240160231A1
公开(公告)日：2024-05-16
申请号：US18395300
申请日：2023-12-22
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts
IPC: G05D7/06 , B01F25/314 , B01F33/302 , B01J19/00 , B01L3/00 , B01L3/02 , G01N1/38 , G01N35/08
CPC classification number: G05D7/0694 , B01F25/314 , B01F33/3021 , B01J19/0046 , B01L3/0293 , B01L3/502784 , G01N1/38 , G01N35/08 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/502746 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , G01N2035/1034 , Y10T137/0318
Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
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公开(公告)号：US11975319B2
公开(公告)日：2024-05-07
申请号：US17049608
申请日：2019-04-23
Applicant: cytena GmbH
Inventor： Jonas Schöndube , Lena Lautscham
CPC classification number: B01L3/0293 , C12M47/04 , G01N15/1456 , B01L2200/0652 , B01L2200/143 , B01L2300/0663 , B01L2300/168 , G01N2015/0053 , G01N2015/1486
Abstract: The invention relates to a dispensing device having a dispenser for dispensing a liquid containing at least one cell and/or at least one particle and an optical detection device for optically detecting at least a region of the dispenser, which has a light source for emitting an illuminating light for illuminating the region and a deflection device for deflecting a detection light emanating from the region. The dispensing device is characterised in that the deflection device deflects the detection light at least twice, in particular exactly twice.
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5.发明公开
公开(公告)号：US20240053374A1
公开(公告)日：2024-02-15
申请号：US18256119
申请日：2021-12-07
Applicant: BIONEER CORPORATION
Inventor： Han Oh PARK , Hanee PARK , Jong Kab KIM , Dae Seong IM , Eun Yeong KWON
CPC classification number: G01N35/1067 , G01N35/1079 , B01L7/52 , B01L3/50851 , B01L3/0293 , G01N2035/1069 , G01N2035/00346
Abstract: The invention relates to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system and, more specifically, to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system, in which dispensing of a liquid sample and extraction, amplification and testing of nucleic acids are integrally carried out. The sample tube opening/closing device includes: a housing that forms an inner space isolated from the outside and includes a door for carrying in/out a multi-well plate for biological samples, including a plurality of sample tubes in which biological samples are accommodated; and a sample tube opening/closing part that is installed in the inner space to be spaced apart from the multi-well plate for biological samples and automatically opens and closes the sample tubes.
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公开(公告)号：US20230386815A1
公开(公告)日：2023-11-30
申请号：US18227417
申请日：2023-07-28
Inventor： Livia Schiavinato EBERLIN , Thomas MILNER , Jialing ZHANG , John LIN , John RECTOR , Nitesh KATTA , Aydin ZAHEDIVASH
IPC: H01J49/04 , H01J49/00 , A61B10/00 , G01N33/487 , B01L3/00 , G01N33/68 , G01N1/02 , G01N30/72 , G01N33/574
CPC classification number: H01J49/0431 , H01J49/0031 , A61B10/0045 , G01N33/487 , B01L3/502 , G01N33/6848 , G01N1/02 , G01N30/72 , H01J49/04 , G01N33/574 , G01N2560/00 , B01L2400/0655 , B01L2200/0605 , B01L3/0293
Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
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公开(公告)号：US11684919B2
公开(公告)日：2023-06-27
申请号：US16772179
申请日：2018-12-13
Applicant: Creoptix AG
Inventor： Kaspar Cottier
CPC classification number: B01L3/502715 , B01L3/0293 , B01L3/50273 , B01L2200/143 , B01L2300/0829 , B01L2300/0877 , B01L2400/049 , B01L2400/0633
Abstract: Methods for screening a plurality of sample fluids for molecules which can bind to predefined ligands, comprising, selecting one of a plurality of flow cell groups by fluidly connecting the selected flow cell group to a sample delivery unit; injecting a sample fluid to be screened from the sample delivery unit into the flow cells in the selected flow cell group; for each flow cell in the selected flow cell group, recording a signal using a sensor which represents the binding and/or the dissociation of molecules of the sample fluid to/from ligands on the test surface of that flow cell; carrying out a damage assessment step using said recorded signals; if it is determined that the test surface of a flow cell in the selected flow cell group is damaged, then fluidly connecting the other flow cell group to the sample delivery unit. There is further provided assemblies which can be used to implement the afore-mentioned methods.
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公开(公告)号：US11660593B2
公开(公告)日：2023-05-30
申请号：US16950384
申请日：2020-11-17
Applicant: Festo SE & Co. KG
Inventor： Tobias Schuster , Jens Engelhardt , Maik Flach , Duc-Thang Vu , Gabor Duroska , Stefan Bammesberger
CPC classification number: B01L3/0237 , B01L3/0293 , F01N3/208 , F15B13/086 , F16K31/046
Abstract: Fluid assembly for use in a fluid system, having a control module including a processing unit for processing control commands into individual electrical control signals with individually adjustable control signal levels and a control signal level electrically connected to the processing unit, with a power unit, which has a power module for converting the control signals into individual electrical control currents as a function of the control signal levels and an output interface electrically connected to the power module, wherein the processing unit is designed to provide a first group of control signals in a first time interval which can be individually predetermined for each control signal and to provide a second group of control signals in a second time interval which can be individually predetermined for each control signal and follows the respective first time interval, wherein the first control signal and the second control signal are selected in such a way that the control currents in the first time interval are greater than the control currents in the second time interval.
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公开(公告)号：US20180348103A1
公开(公告)日：2018-12-06
申请号：US16102242
申请日：2018-08-13
Applicant: Lee H. Angros
Inventor： Lee H. Angros
CPC classification number: G01N1/312 , B01J2219/0036 , B01J2219/00477 , B01J2219/00495 , B01J2219/00533 , B01J2219/00659 , B01L3/0293 , B01L7/54 , B01L2200/04 , B01L2200/16 , B01L2300/0822 , B01L2300/14 , B01L2400/0478 , G01N1/44 , G01N35/00029 , G01N2035/00039 , G01N2035/00138 , G01N2035/00168 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165
Abstract: An apparatus for spreading at least one reagent on at least a portion of a microscope slide includes a spreading device positionable in association with a microscope slide in a way that the spreading device defines a gap between the spreading device and the microscope slide and in a way that the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on at least a portion of the microscope. The spreading device has a reservoir in which the at least one reagent is stored in a way that the at least one reagent is dischargeable from the reservoir onto the microscope slide when the spreading device is positioned in association with the microscope slide.
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公开(公告)号：US20180243744A1
公开(公告)日：2018-08-30
申请号：US15905034
申请日：2018-02-26
Applicant: SYSMEX CORPORATION
Inventor： Kunpeng CAI , Koya YAMAWAKI , Yasuko KAWAMOTO , Katsumi NAKANISHI , Ayato TAGAWA
IPC: B01L3/00 , C12Q1/6806 , G01N33/53
CPC classification number: B01L3/56 , B01L3/0293 , B01L3/502784 , B01L2200/0605 , B01L2200/0647 , B01L2200/0673 , B01L2300/0663 , B01L2400/0487 , B01L2400/082 , C12Q1/6806 , G01N33/5302
Abstract: Disclosed is a liquid sending method for sending liquid to a sample processing chip having a flow path formed therein, the method including: measuring a flow of a second liquid which is different from a first liquid which is introduced into the flow path in the sample processing chip; controlling the flow of the second liquid on the basis of the measured flow; and introducing the first liquid into the flow path in the sample processing chip by means of the second liquid of which flow is controlled.
