LPA receptor agonists and antagonists
    10.
    发明授权
    LPA receptor agonists and antagonists 有权
    LPA受体激动剂和拮抗剂

    公开(公告)号:US08686177B2

    公开(公告)日:2014-04-01

    申请号:US12921140

    申请日:2009-03-03

    申请人: Veeresh Gududuru

    发明人: Veeresh Gududuru

    IPC分类号: C07F9/177

    摘要: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.

    摘要翻译: 公开了根据式(I)的化合物以及包括这些化合物的药物组合物。 还公开了使用这些化合物的方法,其具有活性作为LPA受体的激动剂或拮抗剂; 这些方法包括治疗癌症,产生放射免疫和/或放射疗法,增强细胞增殖,治疗伤口,治疗细胞,组织或器官中的凋亡或维持或恢复功能,培养细胞,保存器官或组织功能,以及治疗皮肤 逻辑条件。