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114 条记录 (耗时 0.043 秒)

    METHOD FOR SYNTHESIZING THYMOSINS
    1.
    发明申请
    METHOD FOR SYNTHESIZING THYMOSINS 审中-公开
    合成丝氨酸的方法

    公开(公告)号：US20110166071A1

    公开(公告)日：2011-07-07

    申请号：US12300193

    申请日：2007-04-25

    申请人： Jimena Fernandez Carneado ,  Berta Ponsati Obiols ,  Javier Clemente Rodriguez ,  Raimon Rubires Ferrer ,  Sergi Pavon Fernandez

    发明人： Jimena Fernandez Carneado ,  Berta Ponsati Obiols ,  Javier Clemente Rodriguez ,  Raimon Rubires Ferrer ,  Sergi Pavon Fernandez

    IPC分类号： A61K38/22 ,  C07K14/575 ,  A61P37/04

    CPC分类号： C07K1/065 ,  A61K38/00 ,  C07K14/57581

    摘要： The invention relates to a method for obtaining thymosins and/or the pharmaceutically acceptable salts thereof by means of solid-phase synthesis on polymeric supports, which comprises the steps of linearly synthesizing the thymus-derived peptides in solid phase, incorporating at least one Thr or Ser in the sequence, in pseudoproline dipeptide form, obtaining the thymosins by treating the peptidyl resin with trifluoroacetic acid, and purifying the thymosins by RP-HPLC. The present invention also protects the isolated and/or purified compound obtained by means of said method and also the use thereof in the preparation of a medicinal product.

    摘要翻译： 本发明涉及通过固相合成在聚合物载体上获得胸腺素和/或其药学上可接受的盐的方法，该方法包括以下步骤：在固相中线性合成来自胸腺的肽，并入至少一种Thr或 以脯氨酸二肽形式顺序序列，通过用三氟乙酸处理肽基树脂获得胸腺素，并通过RP-HPLC纯化胸腺素。 本发明还保护通过所述方法获得的分离和/或纯化的化合物以及其在制备药物中的用途。

    Derivates of Polyethylene Glycol Modified Thymosin Alpha 1
    2.
    发明申请
    Derivates of Polyethylene Glycol Modified Thymosin Alpha 1 审中-公开
    聚乙二醇改性胸腺素α衍生物1

    公开(公告)号：US20100184653A1

    公开(公告)日：2010-07-22

    申请号：US12172607

    申请日：2008-07-14

    申请人： Huijuan Zhong

    发明人： Huijuan Zhong

    IPC分类号： A61K38/22 ,  C07K14/575 ,  C07K1/00

    CPC分类号： C07K14/57581 ,  A61K38/00 ,  A61K47/60

    摘要： Pharmaceutical compositions that include thymosin alpha 1 peptide derivatives modified at the C-terminal of the peptide chain with polyethylene glycol, and their pharmaceutical acceptable salts, are generally disclosed. Also, new methods used to prepare these thymosin alpha 1 peptide derivatives modified at the C-terminal of the peptide chain with polyethylene glycol are generally provided. The presently disclosed compounds and their salts can be prepared administered to humans to treat immune disease and can also be used in adjuvant treatment.

    摘要翻译： 通常公开了包括在肽链的C-末端修饰的胸腺素α1肽衍生物与聚乙二醇的药物组合物及其药学上可接受的盐。 此外，通常提供用于制备在聚乙二醇的C链末端修饰的这些胸腺素α1肽衍生物的新方法。 目前公开的化合物及其盐可以制备施用于人以治疗免疫疾病，并且还可以用于辅助治疗。

    Peptides for Promoting Hair Growth and Improving Wrinkle and Cosmetic Compositions Comprising the same
    3.
    发明申请
    Peptides for Promoting Hair Growth and Improving Wrinkle and Cosmetic Compositions Comprising the same 有权
    用于促进头发生长和改善皱纹和化妆品组合物的肽包括它们

    公开(公告)号：US20090054349A1

    公开(公告)日：2009-02-26

    申请号：US12083969

    申请日：2006-10-24

    申请人： Yong Ji Chung ,  Young Deug Kim ,  Chung Ryul Kim

    发明人： Yong Ji Chung ,  Young Deug Kim ,  Chung Ryul Kim

    IPC分类号： A61K38/00 ,  C07K7/00 ,  A61P17/00

    CPC分类号： C07K14/57581

    摘要： The present invention relates to a peptide comprising a specific amino acid sequence possessing human thymosin β-4 (Tβ4) activities and its uses. The peptide of this invention has identical or similar functions or actions to human Tβ4 and its biological activity is almost identical to natural-occurring Tβ4. In addition, the peptide of this invention exhibits much higher stability and skin permeation than natural-occurring Tβ4. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in thymosin β-4-effective disorders or conditions. In addition, the peptide of this invention can be advantageously applied to drugs, cosmetics, toothpaste and compositions for mouth cleaning and caring, most preferably, cosmetics. Specifically, the peptide of this invention is advantageously applied to cosmetics for promoting hair growth.

    摘要翻译： 本发明涉及包含具有人胸腺素β-4（Tbeta4）活性的特定氨基酸序列的肽及其用途。 本发明的肽对人Tbeta4具有相同或相似的功能或作用，其生物活性几乎与天然存在的Tbeta4相同。 此外，本发明的肽比天然存在的Tbeta4显示出更高的稳定性和皮肤渗透性。 在这些连接中，包含本发明的肽的组合物可以在改善胸腺素β-4有效障碍或病症方面表现出优异的效力。 此外，本发明的肽可以有利地应用于药物，化妆品，牙膏和用于口腔清洁和护理的组合物，最优选化妆品。 具体地说，本发明的肽有利地用于促进头发生长的化妆品中。

    Human Thymosin, beta15 gene, protein and uses thereof
    6.
    发明申请
    Human Thymosin, beta15 gene, protein and uses thereof 审中-公开
    人胸腺素，β15基因，蛋白质及其用途

    公开(公告)号：US20040101910A1

    公开(公告)日：2004-05-27

    申请号：US10726422

    申请日：2003-12-03

    申请人： Children's Medical Center Corporation

    发明人： Bruce R. Zetter ,  Lere Bao

    IPC分类号： G01N033/53 ,  C07K016/40

    CPC分类号： C07K14/57581 ,  A61K38/00 ,  C07K16/26 ,  C07K2319/00

    摘要： The present inventors have now discovered that humans have a gene that encodes a novel protein of the thymosin null family. This novel protein, herein referred to as thymosin null 15, has the ability to bind and sequester G-actin, like other members of the thymosin null family, but unlike what is known about other members it also directly regulates cell motility in prostatic carcinoma cells. The present invention is direct to an isolated cDNA encoding the human thymosin null 15 gene (SEQ ID NO: 1) and have deduced the amino acid sequence (SEQ ID NO: 2).

    摘要翻译： 本发明人现已发现人类具有编码胸腺素β家族的新蛋白质的基因。 这种称为胸腺素β15的新型蛋白质具有与其他成员胸腺素β家族结合并螯合G-肌动蛋白的能力，但与其他成员不同，它也直接调节前列腺癌细胞中的细胞运动性 。 本发明直接涉及编码人胸腺素β15基因（SEQ ID NO：1）的分离的cDNA并推断出氨基酸序列（SEQ ID NO：2）。

    Novel polypeptides homologous to thymosin, ephrin a receptors, and fibromodulin, and polynucleotides encoding same
    7.
    发明申请
    Novel polypeptides homologous to thymosin, ephrin a receptors, and fibromodulin, and polynucleotides encoding same 失效
    与胸腺素，ephrin a受体和纤维调节蛋白同源的新型多肽，以及编码其的多核苷酸

    公开(公告)号：US20030203426A1

    公开(公告)日：2003-10-30

    申请号：US09973424

    申请日：2001-10-09

    发明人： Sudhirdas K. Prayaga ,  Raymond J. Taupier JR. ,  Raj Bandaru

    IPC分类号： C07K014/705 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/4725 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/57581 ,  C07K14/705

    摘要： Disclosed herein are novel human nucleic acid sequences that have homology to thymosin, ephrin A receptors, proteoglycans and fibromodulin. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving these novel nucleic acids and proteins.

    摘要翻译： 本文公开了与胸腺素，ephrin A受体，蛋白聚糖和纤维调节素具有同源性的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及这些新型核酸和蛋白质的病症的治疗，诊断和研究方法。