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公开(公告)号:US6017728A
公开(公告)日:2000-01-25
申请号:US978454
申请日:1997-11-25
申请人: Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Michael Arthur Lonetto
发明人: Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Michael Arthur Lonetto
IPC分类号: C12N15/09 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , C07K14/315 , C07K16/12 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/10 , C12P21/06 , C07H17/00 , C12N9/00 , C12N15/00
CPC分类号: C12N9/1085 , C07K14/3156 , C12Y205/01009 , A61K38/00 , A61K39/00
摘要: The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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公开(公告)号:US08685670B2
公开(公告)日:2014-04-01
申请号:US11569957
申请日:2005-06-03
申请人: Fernando Alberto Goldbaum , Diego Andrés Laplagne , Vanesa Zylberman , Patricio Craig , Paula Mercedes Berguer , Natalia Ainciart , Carlos Alberto Fossati , Carlos Alejandro Velikovsky , Juliana Cassataro , Guillermo Giambartolomei
发明人: Fernando Alberto Goldbaum , Diego Andrés Laplagne , Vanesa Zylberman , Patricio Craig , Paula Mercedes Berguer , Natalia Ainciart , Carlos Alberto Fossati , Carlos Alejandro Velikovsky , Juliana Cassataro , Guillermo Giambartolomei
CPC分类号: C12N9/1085 , C07K2319/00 , C12Y205/01009
摘要: Isolated chimeric proteins including up to ten copies of peptides, polypeptides or protein domains inserted in the amino termini of the Brucella spp. Lumazine synthase enzyme. Isolated nucleotide sequences codifying the chimeric proteins. Vectors, plasmids and transformed cells used for expressing the proteins. Monoclonal and polyclonal antibodies induced by the chimeric proteins. Hybridomas producing the monoclonal antibodies. Vaccines and pharmaceutical compounds including the chimeric proteins, nucleotide sequences and antibodies. A method to induce an immune response in higher organisms including the administration of effective amounts of the vaccines and pharmaceutical compounds. Biosensors including the chimeric proteins. Protein conjugates formed by the chimeric proteins and a ligand bound by means of covalent and noncovalent bonds. Uses of the chimeric proteins, nucleotide sequences, vectors, plasmids, transformed cells, antibodies, hybridomas, conjugates, biosensors, vaccines and pharmaceutical compounds. The quaternary structure of the chimeric proteins.
摘要翻译: 分离的嵌合蛋白包括插入布鲁氏菌属(Brucella spp)氨基末端的多达十个拷贝的肽,多肽或蛋白质结构域。 Lumazine合酶。 分离嵌合蛋白的核苷酸序列。 用于表达蛋白质的载体,质粒和转化细胞。 由嵌合蛋白诱导的单克隆和多克隆抗体。 产生单克隆抗体的杂交瘤。 包括嵌合蛋白,核苷酸序列和抗体的疫苗和药物化合物。 在高等生物体中诱导免疫应答的方法,包括施用有效量的疫苗和药物化合物。 生物传感器包括嵌合蛋白。 通过嵌合蛋白形成的蛋白质缀合物和通过共价键和非共价键结合的配体。 嵌合蛋白,核苷酸序列,载体,质粒,转化细胞,抗体,杂交瘤,缀合物,生物传感器,疫苗和药物化合物的用途。 嵌合蛋白的四级结构。
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公开(公告)号:US20090087435A1
公开(公告)日:2009-04-02
申请号:US11569957
申请日:2005-06-03
申请人: Fernando Goldbaum , Diego Andres Laplagne , Vanesa Zylberman , Patricio Craig , Paula Mercedes Berguer , Natalia Ainciart , Carlos Alberto Fossati , Carlos Alejandro Velikovsky , Juliana Cassataro , Guillermo Giambartolomei
发明人: Fernando Goldbaum , Diego Andres Laplagne , Vanesa Zylberman , Patricio Craig , Paula Mercedes Berguer , Natalia Ainciart , Carlos Alberto Fossati , Carlos Alejandro Velikovsky , Juliana Cassataro , Guillermo Giambartolomei
IPC分类号: A61K38/00 , C12N9/00 , C12N15/11 , A61K38/43 , A61K38/05 , C07K16/00 , A61K39/395 , C12M1/00 , C12N5/12 , C07K16/12 , A61K39/02 , A61K31/7088 , C12N15/63 , C12N1/21
CPC分类号: C12N9/1085 , C07K2319/00 , C12Y205/01009
摘要: isolated chimeric proteins including up to ten copies of peptides, polypeptides or protein domains inserted in the amino termini of the Brucella spp. Lumazine synthase enzyme. Isolated nucleotide sequences codifying the chimeric proteins. Vectors, plasmids and transformed cells used for expressing the proteins. Monoclonal and polyclonal antibodies induced by the chimeric proteins. Hybridomas producing the monoclonal antibodies. Vaccines and pharmaceutical compounds including the chimeric proteins, nucleotide sequences and antibodies. A method to induce an immune response in higher organisms including the administration of effective amounts of the vaccines and pharmaceutical compounds. Biosensors including the chimeric proteins. Protein conjugates formed by the chimeric proteins and a ligand bound by means of covalent and noncovalent bonds. Uses of the chimeric proteins, nucleotide sequences, vectors, plasmids, transformed cells, antibodies, hybridomas, conjugates, biosensors, vaccines and pharmaceutical compounds. The quaternary structure of the chimeric proteins.
摘要翻译: 分离的嵌合蛋白,包括插入Brucella spp氨基末端的多达十个拷贝的肽,多肽或蛋白质结构域。 Lumazine合酶。 分离嵌合蛋白的核苷酸序列。 用于表达蛋白质的载体,质粒和转化细胞。 由嵌合蛋白诱导的单克隆和多克隆抗体。 产生单克隆抗体的杂交瘤。 包括嵌合蛋白,核苷酸序列和抗体的疫苗和药物化合物。 在高等生物体中诱导免疫应答的方法,包括施用有效量的疫苗和药物化合物。 生物传感器包括嵌合蛋白。 通过嵌合蛋白形成的蛋白质缀合物和通过共价键和非共价键结合的配体。 嵌合蛋白,核苷酸序列,载体,质粒,转化细胞,抗体,杂交瘤,缀合物,生物传感器,疫苗和药物化合物的用途。 嵌合蛋白的四级结构。
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公开(公告)号:US20160137701A1
公开(公告)日:2016-05-19
申请号:US14902484
申请日:2014-07-03
发明人: Elisabeth LINDNER , Helena COWLEY , Aaron COWLEY
CPC分类号: C07K14/195 , A61K35/74 , A61K38/00 , A61K38/164 , C12N9/0006 , C12N9/0016 , C12N9/0051 , C12N9/1014 , C12N9/1085 , C12N9/14 , C12N9/88 , C12Y101/0106 , C12Y104/01016 , C12Y108/01 , C12Y201/02001 , C12Y205/01006 , C12Y205/01009 , C12Y205/01047 , C12Y303/01001 , C12Y402/01003
摘要: The present invention relates to a secretagogue compound derived from oxalate degrading bacteria, for use in the treatment of an oxalate related disease and/or oxalate related imbalance in a subject, wherein the administration of the secretagogue results in a reduction of urinary oxalate and/or plasma oxalate in the subject. The invention further relates to a pharmaceutical composition comprising such a secretagogue compound, a method for treating a subject suffering from an oxalate related disease, and to a method for preparing a secretagogue.
摘要翻译: 本发明涉及一种衍生自草酸降解细菌的促分泌素化合物,用于治疗受试者中草酸盐相关疾病和/或草酸盐相关不平衡,其中所述促分泌素的施用导致尿草酸盐和/或 受试者血浆草酸盐。 本发明还涉及包含这种促分泌素化合物的药物组合物,用于治疗患有草酸盐相关疾病的受试者的方法和用于制备促分泌素的方法。
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公开(公告)号:US20020091236A1
公开(公告)日:2002-07-11
申请号:US09861345
申请日:2001-05-18
发明人: Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号: C07K001/00 , C07K014/00 , C07K017/00
CPC分类号: C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12Y205/01009 , C12Y207/01002
摘要: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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公开(公告)号:US06448036B1
公开(公告)日:2002-09-10
申请号:US08977866
申请日:1997-11-25
申请人: Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人: Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号: C07H2104
CPC分类号: C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C12N9/78 , C12Y205/01009 , C12Y305/04025
摘要: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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公开(公告)号:US06252044B1
公开(公告)日:2001-06-26
申请号:US08977555
申请日:1997-11-25
申请人: Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
发明人: Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
IPC分类号: C07K100
CPC分类号: C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12Y205/01009 , C12Y207/01002
摘要: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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公开(公告)号:US06171835B2
公开(公告)日:2001-01-09
申请号:US09385288
申请日:1999-08-30
申请人: Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
发明人: Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号: C12N900
CPC分类号: C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12Y205/01009
摘要: The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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