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    Kell protein proteolytic activity
    3.
    发明授权
    Kell protein proteolytic activity 有权
    凯尔蛋白蛋白水解活性

    公开(公告)号：US6063592A

    公开(公告)日：2000-05-16

    申请号：US192048

    申请日：1998-11-13

    申请人： Soohee Lee

    发明人： Soohee Lee

    IPC分类号： C07K14/575 ,  C12N9/64 ,  C12P21/00 ,  C12N9/48 ,  C12N9/50

    CPC分类号： C12N9/6497 ,  C07K14/57536 ,  C07K14/57563 ,  C12Y304/24071

    摘要： A method for cleaving polypeptides includes contacting a polypeptide with a recombinant or isolated Kell protein having proteolytic activity for the polypeptide. A method for converting big endothelins-1, -2 and -3 to endothelins-1, -2 and -3 respectively comprises contacting the big endothelin with Kell protein having proteolytic activity for cleaving big endothelin-1, -2 and -3 to endothelin-1, -2 or -3 respectively. In another embodiment, the Kell protein cleaves vasoactive intestinal peptide.

    摘要翻译： 用于切割多肽的方法包括使多肽与具有多肽蛋白水解活性的重组或分离的凯尔蛋白质接触。 将大内皮素-1，-2和-3转化为内皮素-1，-2和-3的方法分别包括使大内皮素与具有蛋白水解活性的凯尔蛋白接触，以将大内皮素-1,2和-3切割成内皮素 -1，-2或-3。 在另一个实施方案中，凯尔蛋白切割血管活性肠肽。

    Screening and Treatment Methods Using IGS5 Enzymes of the Metalloprotease Family
    4.
    发明申请
    Screening and Treatment Methods Using IGS5 Enzymes of the Metalloprotease Family 失效
    使用金属蛋白酶家族的IGS5酶的筛选和治疗方法

    公开(公告)号：US20110262930A1

    公开(公告)日：2011-10-27

    申请号：US13115569

    申请日：2011-05-25

    申请人： Willy DELEERSNIJDER ,  Yasmin Karimi-Nejad ,  Michael Weske ,  Dieter Ziegler

    发明人： Willy DELEERSNIJDER ,  Yasmin Karimi-Nejad ,  Michael Weske ,  Dieter Ziegler

    IPC分类号： C12Q1/68 ,  C12Q1/37

    CPC分类号： G01N33/573 ,  A61K38/00 ,  C12N9/6489 ,  C12N9/6497 ,  C12Y304/24071 ,  G01N2333/96486 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2800/28

    摘要： Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing such polynucleotides, host cells containing such vectors, processes for producing such polypeptides and/or polynucleotides, screening methods for identifying compounds which stimulate or inhibit IGS5 polypeptides and/or polynucleotides, and the use of such polypeptides and/or polynucleotides in therapy of various dysfunctions, disorders or diseases, particularly cardiovascular diseases, metabolic diseases such as diabetes mellitus type II, and neurodegenerative disorders, such as Parkinson's Disease.

    摘要翻译： 与neprilysin酶家族相关并具有锌金属蛋白酶活性并被称为IGS5的多肽，编码这种多肽的多核苷酸，含有这种多核苷酸的载体，含有这种载体的宿主细胞，产生此类多肽和/或多核苷酸的方法，筛选方法 识别刺激或抑制IGS5多肽和/或多核苷酸的化合物，以及这些多肽和/或多核苷酸在治疗各种功能障碍，疾病或疾病，特别是心血管疾病，代谢疾病如II型糖尿病和神经变性疾病中的应用， 如帕金森病。

    Screening and treatment methods using IGS5 enzymes of the metalloprotease family
    8.
    发明申请
    Screening and treatment methods using IGS5 enzymes of the metalloprotease family 有权
    使用金属蛋白酶家族的IGS5酶的筛选和处理方法

    公开(公告)号：US20070224180A1

    公开(公告)日：2007-09-27

    申请号：US11712452

    申请日：2007-03-01

    申请人： Willy Deleersnijder ,  Yasmin Karimi-Nejad ,  Michael Weske ,  Dieter Ziegler

    发明人： Willy Deleersnijder ,  Yasmin Karimi-Nejad ,  Michael Weske ,  Dieter Ziegler

    IPC分类号： A61K38/43 ,  G01N33/53

    CPC分类号： G01N33/573 ,  A61K38/00 ,  C12N9/6489 ,  C12N9/6497 ,  C12Y304/24071 ,  G01N2333/96486 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2800/28

    摘要： Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing such polynucleotides, host cells containing such vectors, processes for producing such polypeptides and/or polynucleotides, screening methods for identifying compounds which stimulate or inhibit IGS5 polypeptides and/or polynucleotides, and the use of such polypeptides and/or polynucleotides in therapy of various dysfunctions, disorders or diseases, particularly cardiovascular diseases, metabolic diseases such as diabetes mellitus type II, and neurodegenerative disorders, such as Parkinson's Disease.

    摘要翻译： 与neprilysin酶家族相关并具有锌金属蛋白酶活性并被称为IGS5的多肽，编码这种多肽的多核苷酸，含有这种多核苷酸的载体，含有这种载体的宿主细胞，产生此类多肽和/或多核苷酸的方法，筛选方法 识别刺激或抑制IGS5多肽和/或多核苷酸的化合物，以及这些多肽和/或多核苷酸在治疗各种功能障碍，疾病或疾病，特别是心血管疾病，代谢疾病如II型糖尿病和神经变性疾病中的应用， 如帕金森病。

    Use for endothelin converting enzyme 2 (ECE-2) in the diagnosis and treatment of metabolic disorders
    10.
    发明申请
    Use for endothelin converting enzyme 2 (ECE-2) in the diagnosis and treatment of metabolic disorders 审中-公开
    用于内皮素转化酶2（ECE-2）在代谢紊乱的诊断和治疗中的应用

    公开(公告)号：US20030232044A1

    公开(公告)日：2003-12-18

    申请号：US10453764

    申请日：2003-06-03

    申请人： Millennium Pharmaceuticals, Inc.

    发明人： David White

    IPC分类号： A61K038/48 ,  C12Q001/68 ,  G01N033/53 ,  C07K016/40

    CPC分类号： C12Y304/24071 ,  A61K38/4886 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y304/00 ,  G01N2333/96486

    摘要： The invention relates to methods and compositions for the diagnosis and treatment of metabolic disorders including, but not limited to, obesity, diabetes, overweight, insulin resistance, anorexia, and cachexia; and disorders of appetite regulation, including hyperphagia. The invention further provides methods for identifying a compound capable of treating a metabolic disorder or a disorder of appetite regulation. The invention also provides methods for identifying a compound capable of modulating a metabolic activity or regulation of appetite. Yet further, the invention provides methods for modulating a metabolic activity and methods for modulating appetite regulation. In addition, the invention provides methods for treating a subject having a metabolic disorder or a disorder of appetite regulation characterized by aberrant ECE-2 polypeptide activity or aberrant ECE-2 nucleic acid expression.

    摘要翻译： 本发明涉及用于诊断和治疗代谢紊乱的方法和组合物，包括但不限于肥胖症，糖尿病，超重，胰岛素抵抗，厌食和恶病质; 和食欲调节障碍，包括食欲不振。 本发明还提供了鉴定能够治疗代谢紊乱或食欲调节障碍的化合物的方法。 本发明还提供了鉴定能调节代谢活性或调节食欲的化合物的方法。 此外，本发明提供了调节代谢活性的方法和调节食欲调节的方法。 此外，本发明提供了治疗以异常的ECE-2多肽活性或异常的ECE-2核酸表达为特征的代谢紊乱或食欲调节障碍的受试者的方法。