公开(公告)号：US20180275049A1

公开(公告)日：2018-09-27

申请号：US15765029

申请日：2016-09-30

申请人： CONSIGLIO NAZIONALE DELLE RICERCHE - CNR

发明人： Davide Mazzotti ,  Pablo Cancio Pastor ,  Iacopo Galli ,  Paolo De Natale ,  Giovanni Giusfredi

IPC分类号： G01N21/3504 ,  G01J3/42

CPC分类号： G01N21/3504 ,  G01J3/42 ,  G01N2021/391 ,  G01N2201/06113 ,  G01N2201/129

摘要： The present invention is relative to a method of ring-down spectroscopy in saturated-absorption condition, for measuring a first concentration of a gas through a measurement of the spectrum of a molecular transition of said gas.

公开(公告)号：US20180275048A1

公开(公告)日：2018-09-27

申请号：US15467361

申请日：2017-03-23

申请人： Lakehead University

发明人： Gautam Das

IPC分类号： G01N21/3504 ,  G01N21/359 ,  G02B6/02

CPC分类号： G01N21/3504 ,  F16L15/008 ,  G01N21/359 ,  G01N21/39 ,  G01N2021/391 ,  G01N2201/088 ,  G02B6/02076 ,  G02B6/02328 ,  G02B6/4248

摘要： Unique gas cell constructions based on a hollow-core photonic crystal fiber are used, for example, inside a fiber ring laser cavity as an intracavity gas cell. In one embodiment, two simple terminal blocks are coupled to opposite ends of the hollow-core photonic crystal fiber. Each block features a main through-bore with an optical window at one end and an optical fiber chuck fitted at the other end, while a transverse bore intersects the main bore and features a gas fitting for connection to a gas source or vacuum pump. In another embodiment, the hollow-core photonic crystal fiber is contained within an enclosure whose exterior walls are fitted with optical windows and gas ports. Inside the enclosure, fiber clamps supports the ends of the hollow-core photonic crystal fiber at positions adjacent to an in alignment with the optical windows.

公开(公告)号：US20170067822A1

公开(公告)日：2017-03-09

申请号：US15336045

申请日：2016-10-27

申请人： NewSouth Innovations Pty Limited

发明人： Charles Charbel HARB ,  Toby Kristian BOYSON

IPC分类号： G01N21/39 ,  G01J3/02 ,  G01J3/433

CPC分类号： G01N21/39 ,  G01J3/0208 ,  G01J3/433 ,  G01J2003/4332 ,  G01J2003/4334 ,  G01N21/031 ,  G01N2021/391 ,  G01N2201/0691

摘要： Methods and apparatuses (500) of generating and processing a real-time time-domain cavity ringdown spectroscopy (CRDS) signal from absorbing species m an optical detection system having an optical ringdown cavity (200) using off-axis paths (230) are provided. At least one modulated light signal (570) is generated using one or more light sources (520), each modulated at specified modulation frequency. Each modulated signal has harmonic frequency components and is input off-axis (230) relative to the cavity's optical axis (220). The cavity contains mirrors (210, 212, 214; 310; 410; 510, 512, 514) arranged in a predetermined configuration. The optical axis (220) is defined by a path passing through centers of mirrors (210, 212, 214; 310; 410; 510, 512, 514). The modulated light signal (570) is resonated off axis (230) without astigmatic optical. elements to produce CRDS signal and passes at least twice through cavity and across the mirrors (210, 212, 214; 310; 410; 510, 512, 814) without interfering, with itself. An overall path length through cavity is greater than path length of optical axis. A photodetector detects (550) the CROS signal, which is demodulated (560) dependent upon selected harmonics.

摘要翻译： 提供了在具有使用离轴路径（230）的具有光学环形腔（200）的光学检测系统中从吸收物质生成和处理实时时域空穴衰减光谱（CRDS）信号的方法和装置（500） 。 使用一个或多个光源（520）产生至少一个调制光信号（570），每个光源以规定的调制频率被调制。 每个调制信号具有谐波频率分量，并且相对于空腔的光轴（220）输入离轴（230）。 腔体包含以预定构造布置的反射镜（210,212,214; 310; 410; 510,512,514）。 光轴（220）由穿过反射镜（210,212,214; 310; 410; 510,512,514）的中心的路径限定。 调制光信号（570）在没有散光光学的情况下离轴（230）谐振。 元件以产生CRDS信号并且通过腔并至少穿过镜子（210,212,214; 310; 410; 510,512,814），而不会自身干涉。 通过腔的总路径长度大于光轴的路径长度。 光电检测器检测（550）取决于所选谐波的解调（560）的CROS信号。

公开(公告)号：US20150103353A1

公开(公告)日：2015-04-16

申请号：US14052618

申请日：2013-10-11

申请人： LI-COR, Inc.

发明人： Serguei Koulikov

IPC分类号： G01J3/45

CPC分类号： G01J3/027 ,  G01J3/42 ,  G01J3/45 ,  G01N21/41 ,  G01N2021/391 ,  G01N2021/399

摘要： Systems and methods for controlling the optical path length between a feedback enabled laser and a cavity, and hence the optical feedback phase. A phasor element, positioned along an optical path between the laser and the cavity coupling mirror, includes a gas medium within a volume defined by the phasor element. The phasor element is configured to adjust or control an optical path length of the laser light between the laser and the cavity coupling mirror by adjusting or controlling a density of the gas medium within the phasor volume.

摘要翻译： 用于控制反馈使能的激光器和空腔之间的光程长度的系统和方法，并因此控制光学反馈阶段。 沿着激光器和腔耦合镜之间的光路定位的相量元件包括由相量元件限定的体积内的气体介质。 相量元件被配置为通过调节或控制相量体积内的气体介质的密度来调节或控制激光和腔耦合反射镜之间的激光的光路长度。

公开(公告)号：US07767444B2

公开(公告)日：2010-08-03

申请号：US11139610

申请日：2005-05-31

申请人： Ai Qun Liu ,  Xiao Jun Liang ,  Xu Ming Zhang ,  Yi Sun

发明人： Ai Qun Liu ,  Xiao Jun Liang ,  Xu Ming Zhang ,  Yi Sun

IPC分类号： C12M1/34 ,  C12M3/00 ,  G01N21/00

CPC分类号： G01N21/0303 ,  G01N21/03 ,  G01N21/39 ,  G01N2021/0346 ,  G01N2021/391 ,  G01N2021/399 ,  Y10S435/808

摘要： An apparatus and method for analyzing biological cells and other particles using an external laser cavity. Microfluidic channels contain and transport biological cells to be analyzed. A laser diode provides light for cell analysis. An external cavity is provided between one surface of the laser diode and a mirror opposite thereto. A microlens set focuses the light on only one cell as it passes through the external cavity. The presence of the cell in the external cavity gives a weak feedback toward the laser diode. The emission frequency and the output power of the laser are both functions of the length of the external cavity. Therefore, the variation of cavity length can be deduced from these parameters, where the variation is caused by changing the refractive index or size of the cell in the cavity.

摘要翻译： 使用外部激光腔分析生物细胞和其他颗粒的装置和方法。 微流体通道含有并转运待分析的生物细胞。 激光二极管为光源分析提供光源。 在激光二极管的一个表面和与之相对的镜子之间设置一个外部空腔。 微透镜组在通过外部空腔时将光聚焦在仅一个单元上。 外部腔中存在电池给激光二极管带来弱反馈。 激光器的发射频率和输出功率都是外腔长度的函数。 因此，可以从这些参数推导出腔长度的变化，其中通过改变空腔中的电池的折射率或尺寸引起变化。

公开(公告)号：US07612885B2

公开(公告)日：2009-11-03

申请号：US11615617

申请日：2006-12-22

申请人： Barrett E. Cole ,  James Allen Cox ,  Yuandong Gu ,  Rodney H. Thorland

发明人： Barrett E. Cole ,  James Allen Cox ,  Yuandong Gu ,  Rodney H. Thorland

IPC分类号： G01N21/00

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/42 ,  G01N21/15 ,  G01N21/39 ,  G01N2021/151 ,  G01N2021/391

摘要： The invention is a method and apparatus capable of detecting constituents of a gas at extremely low concentrations comprising providing a medium that is absorbent of at least a first particular gas under a first environmental condition and desorbent of the particular gas under a second environmental condition, exposing the medium to a sample gas for a first period of time under the first environmental condition, during a second period of time after the first period of time, exposing the medium to the second environmental condition to cause the medium to desorb gas into an optical cavity of a cavity ring down spectrometer and introducing electromagnetic radiation into the cavity, during a third period of time after the second period of time, ceasing introduction of the electromagnetic radiation into the cavity and detecting the decay of the electromagnetic radiation in the cavity, and analyzing the decay of the light in the cavity to obtain a spectral analysis of the sample gas.

摘要翻译： 本发明是能够以非常低的浓度检测气体的成分的方法和装置，其包括在第一环境条件下提供至少第一特定气体的吸收剂的介质和在第二环境条件下特定气体的解吸附剂 在第一环境条件下在第一时间段内的样品气体的介质，在第一时间段之后的第二时间段内，将介质暴露于第二环境条件，以使介质将气体解吸到光腔中 的腔环下光谱仪，并在第二时间段内的第三个时间段内将电磁辐射引入空腔，停止将电磁辐射引入空腔中，并检测腔内电磁辐射的衰减，并分析 在空腔中的光的衰减以获得样品气体的光谱分析。

公开(公告)号：US07554673B2

公开(公告)日：2009-06-30

申请号：US11702470

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

IPC分类号： G01B9/02

CPC分类号： G01N21/031 ,  B01L3/5085 ,  B01L2200/10 ,  B01L2300/168 ,  G01J3/26 ,  G01N2021/391

摘要： While two or more analytes within an optical cavity move relative to an array of photosensing elements, the cavity provides output light that has a position/time varying intensity function that depends on optical characteristics of the analytes and on the relative movement. The output light is photosensed to obtain sensing results that depend on the position/time varying intensity function. The sensing results are used to obtain information about at least one of the analytes. The relative movement can, for example, be caused by moving analytes within channels within the cavity, such as by causing flow of a medium that carries the analytes through the channels. Or the analytes can be in wells of a biochip, with the cavity defined by reflective slides on opposite surfaces of the biochip, and the slides and biochip can be caused to move together relative to the array.

摘要翻译： 虽然光学腔内的两个或更多个分析物相对于光敏元件阵列移动，但腔提供具有取决于分析物的光学特性和相对运动的位置/时间变化强度函数的输出光。 输出光被光照以获得取决于位置/时变强度函数的感测结果。 感测结果用于获得关于至少一种分析物的信息。 例如，相对运动可以通过在腔内的通道内移动分析物，例如通过使携带分析物的介质流过通道而引起。 或者分析物可以在生物芯片的孔中，其中空腔由生物芯片的相对表面上的反射片限定，并且可以使载片和生物芯片相对于阵列一起移动。

公开(公告)号：US07504263B2

公开(公告)日：2009-03-17

申请号：US11389852

申请日：2006-03-27

申请人： Kevin K. Lehmann ,  Peter B. Tarsa ,  Paul Rabinowitz

发明人： Kevin K. Lehmann ,  Peter B. Tarsa ,  Paul Rabinowitz

IPC分类号： G01N

CPC分类号： G01N21/39 ,  G01J3/42 ,  G01N21/552 ,  G01N2021/391 ,  G01N2021/7789

摘要： A method for detection and measurement of trace species in a gas or liquid sample is provided. The method comprises forming a sensor from an optical fiber by tapering a portion the optical fiber along a length thereof, exposing the tapered portion of the optic fiber to the sample gas or sample liquid, emitting radiation from a coherent source, coupling at least a portion of the radiation emitted from the coherent source into the fiber optic ring, receiving a portion of the radiation traveling in the fiber optic ring, and determining the level of trace species in the gas or liquid sample based on a rate of decay of the radiation within the fiber optic ring.

摘要翻译： 提供了一种用于检测和测量气体或液体样品中痕量物质的方法。 该方法包括通过使光纤的一部分沿其长度逐渐变细来形成传感器，将光纤的锥形部分暴露于样品气体或样品液体，从相干光源发射辐射，将至少一部分 从相干光源发射到光纤环中的辐射，接收在光纤环中行进的辐射的一部分，以及基于辐射内部的辐射衰减速率来确定气体或液体样品中的痕量物质的水平 光纤环。

公开(公告)号：US07406107B2

公开(公告)日：2008-07-29

申请号：US10953048

申请日：2004-09-29

申请人： Dale C. Flanders ,  Xinfa Ma ,  Walid A. Atia

发明人： Dale C. Flanders ,  Xinfa Ma ,  Walid A. Atia

IPC分类号： H01S3/10

CPC分类号： G01N21/39 ,  G01J1/4257 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/26 ,  G01J3/433 ,  G01J2003/2866 ,  G01N2021/391 ,  G01N2021/399 ,  G01N2201/08 ,  H01S3/08013 ,  H01S3/083 ,  H01S5/005 ,  H01S5/0064 ,  H01S5/02252 ,  H01S5/141

摘要： An optical power control system for a semiconductor source spectroscopy system controls power fluctuations in the tunable signal from the spectroscopy system and thus improves the noise performance of the system. This general solution has advantages relative to other systems that simply detect reference power levels during the scan and then correct the detected signal after interaction with the sample by reducing the requirements for coordinating the operation of the sample detectors and power or reference detectors. The spectroscopy system comprises a semiconductor source and a tunable filter. The combination of the semiconductor source and tunable signal illuminate a sample with a tunable signal, being tunable over a scan band. The power control system comprises an amplitude detector system for detecting the power of the tunable optical signal and power control system for regulating the amplitude of the tunable optical signal in response to its detected power.

摘要翻译： 用于半导体源光谱系统的光功率控制系统控制来自光谱系统的可调谐信号中的功率波动，从而改善系统的噪声性能。 该通用解决方案相对于在扫描期间简单地检测参考功率电平然后在与样品相互作用之后校正检测到的信号的其它系统具有优点，通过减少协调样品检测器和功率或参考检测器的操作的要求。 光谱系统包括半导体源和可调谐滤波器。 半导体源和可调信号的组合用可调信号照射样品，可在扫描带上调谐。 功率控制系统包括用于检测可调谐光信号的功率的振幅检测器系统和用于响应于其检测到的功率来调节可调谐光信号的幅度的功率控制系统。

公开(公告)号：US07354772B2

公开(公告)日：2008-04-08

申请号：US11120030

申请日：2005-05-02

申请人： Naresh Menon ,  John D. Minelly

发明人： Naresh Menon ,  John D. Minelly

IPC分类号： C12Q1/68 ,  G01N21/00 ,  H01L31/00 ,  G01B9/02 ,  H01S3/00 ,  H01S3/08

CPC分类号： G01N21/39 ,  G01N21/253 ,  G01N21/552 ,  G01N21/774 ,  G01N2021/391 ,  G01N2021/7753 ,  G01N2021/7773 ,  G01N2021/7776 ,  G01N2201/06113 ,  G01N2201/08

摘要： A system and method for determining information about an assay. In one embodiment the method includes positioning a filter assembly, having an assay disposed on its surface, relative to a light source such that light from the light source is incident on the filter assembly and at least a portion of the light incident on the filter assembly is reflected from the filter assembly, illuminating the filter assembly with light from the light source, receiving light reflected from the filter assembly in an optical element, analyzing one or more characteristics of the light received in the optical element to determine information about a reaction in the assay, wherein a reaction in the assay results in a change of one or more characteristics of the light received from the filter assembly. In another embodiment, a system for analyzing an assay, comprises a structure in a resonating cavity configured to receive a filter assembly having an assay disposed on a first surface thereof such that the assay is positioned outside the resonating cavity, a light source positioned in the resonating cavity to communicate light to a second surface area of the filter assembly disposed in the resonating cavity, and an analysis system configured to receive light emitted from the filter assembly and detect information about a reaction in the assay based on one or more characteristics of the light.

摘要翻译： 用于确定测定信息的系统和方法。 在一个实施例中，该方法包括相对于光源定位具有设置在其表面上的测定的过滤器组件，使得来自光源的光入射到过滤器组件上，并且入射到过滤器组件上的光的至少一部分 从所述过滤器组件反射，用来自所述光源的光照射所述过滤器组件，接收在所述光学元件中从所述过滤器组件反射的光，分析在所述光学元件中接收的光的一个或多个特性，以确定关于 其中所述测定中的反应导致从所述过滤器组件接收的光的一个或多个特性的变化。 在另一个实施例中，用于分析测定的系统包括谐振腔中的结构，其被配置为接收具有设置在其第一表面上的测定的过滤器组件，使得所述测定位于所述谐振腔外部，光源位于所述 谐振腔以将光传送到设置在谐振腔中的过滤器组件的第二表面区域，以及分析系统，被配置为接收从过滤器组件发射的光，并且基于检测中的一个或多个特性检测关于测定中的反应的信息 光。