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    Sesnsor for detecting a toxic or hazardous gas mixture and operating method
    3.
    发明申请
    Sesnsor for detecting a toxic or hazardous gas mixture and operating method 审中-公开
    用于检测有毒或有害气体混合物的Sesnsor和操作方法

    公开(公告)号：US20090029403A1

    公开(公告)日：2009-01-29

    申请号：US12078794

    申请日：2008-04-04

    申请人： Maximilian Fleischer ,  Mirko Lehmann ,  Elfriede Simon

    发明人： Maximilian Fleischer ,  Mirko Lehmann ,  Elfriede Simon

    IPC分类号： C12Q1/02 ,  C12M1/34

    CPC分类号： C12Q1/025 ,  G01N27/4141 ,  G01N2520/00

    摘要： A sensor for detecting a gas mixture which substantially comprises air and contains one or a plurality of gases that exhibit a disadvantageous effect on living organisms, comprising: a sensor chip composed of silicon for reading out at least one signal which is generated at a sensitive substance given the presence of one or a plurality of target gases in the measurement gas, a sensitive substance applied on the sensor chip, comprising living cells, which respond to target gas, a signal processing unit for evaluating the signals of the Si chip.

    摘要翻译： 一种用于检测气体混合物的传感器，其基本上包括空气并且包含对活生物体具有不利影响的一种或多种气体，包括：由硅组成的传感器芯片，用于读出在敏感物质处产生的至少一种信号 考虑到测量气体中存在一种或多种目标气体，施加在传感器芯片上的敏感物质包括响应于目标气体的活细胞，用于评估Si芯片的信号的信号处理单元。

    Cell-based biosensor for harmful airborne agents
    4.
    发明授权
    Cell-based biosensor for harmful airborne agents 失效
    用于有害空气传播剂的基于细胞的生物传感器

    公开(公告)号：US07195899B1

    公开(公告)日：2007-03-27

    申请号：US10798986

    申请日：2004-03-12

    申请人： Wei-Chun Chin ,  Soonjo Kwon

    发明人： Wei-Chun Chin ,  Soonjo Kwon

    IPC分类号： C12N11/02

    CPC分类号： C12N11/14 ,  C12Q1/24 ,  G01N33/567 ,  G01N2520/00

    摘要： A method of monitoring an air atmosphere for a harmful biological or chemical agent includes providing a plurality of mammalian respiratory airway epithelial cells borne on a porous support; contacting the porous support with a cell nutrient medium and with air by positioning said porous support at an air-liquid interface between the cell nutrient liquid and the air; sampling the air atmosphere to thereby create an air flow over the air-liquid interface so that the respiratory epithelial cells borne on the porous silicone support are contacted by the sampled air; and monitoring the respiratory epithelial cells for at least one physiological parameter indicating the cells have been exposed to the harmful agent.

    摘要翻译： 监测有害生物或化学试剂的空气气氛的方法包括：提供多个哺乳动物呼吸道气道上皮细胞，其承载于多孔载体上; 通过将所述多孔载体定位在细胞营养液体和空气之间的空气 - 液体界面处，使多孔载体与细胞营养培养基和空气接触; 对空气气氛进行取样，从而在空气 - 液体界面上产生空气流，使得承载在多孔硅树脂支撑体上的呼吸上皮细胞与采样空气接触; 以及监测呼吸上皮细胞至少一个表明细胞已经暴露于有害物质的生理参数。

    Transgenic clawed frog embryos and use thereof as detectors of endocrine disrupters in the environment
    5.
    发明申请
    Transgenic clawed frog embryos and use thereof as detectors of endocrine disrupters in the environment 有权
    转基因抓青蛙胚胎及其在环境中用作内分泌干扰物的检测器

    公开(公告)号：US20060101528A1

    公开(公告)日：2006-05-11

    申请号：US10516134

    申请日：2003-05-27

    申请人： Barbara Demeneix ,  Nathalie Turque

    发明人： Barbara Demeneix ,  Nathalie Turque

    IPC分类号： A01K67/027 ,  C12Q1/00 ,  C12N5/06

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/50 ,  A01K2267/0393 ,  G01N33/5014 ,  G01N2333/4606 ,  G01N2500/10 ,  G01N2520/00

    摘要： The invention relates to transgenic aquatic animals, particularly the clawed frog and the zebra fish and cells derived therefrom, characterised in comprising at least one expression cassette with a regulatory DNA sequence selected from the response elements to nuclear hormone receptors, particularly TRE, connected in a functional manner downstream of a DNA segment coding for a marker protein such as luciferase or GFP. The invention further relates to methods using the transgenic cells and animals according to the invention for the identification of endocrine disrupters in the environment.

    摘要翻译： 本发明涉及转基因水生动物，特别是捕获的青蛙和斑马鱼及其衍生的细胞，其特征在于包含至少一个表达盒，其具有选自与核激素受体（特别是TRE）相关的响应元件的调节DNA序列 在编码诸如荧光素酶或GFP的标记蛋白的DNA区段的下游的功能方式。 本发明还涉及使用根据本发明的转基因细胞和动物在环境中鉴定内分泌干扰物的方法。

    High estrogen-sensitive medaka fish
    6.
    发明授权
    High estrogen-sensitive medaka fish 失效
    高雌激素敏感的med鱼

    公开(公告)号：US06759568B2

    公开(公告)日：2004-07-06

    申请号：US09893666

    申请日：2001-06-29

    申请人： Ichiro Yamashita

    发明人： Ichiro Yamashita

    IPC分类号： G01N3300

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/40 ,  A01K2267/03 ,  C07K14/461 ,  G01N33/186 ,  G01N33/5082 ,  G01N33/74 ,  G01N2520/00

    摘要： (1) Transgenic medaka fish into which a polynucleotide having the nucleotide sequence from 211 to 1935 position represented by Sequence ID No: 1 is introduced, (2) A method of producing medaka fish having one or more thrombi, comprising the step of raising the transgenic medaka fish described in (1) in the presence of estrogen, (3) Medaka fish having one or more thrombi produced by the method described in (2), and (4) A method of testing an estrogen-like acting substance, comprising the steps of raising the transgenic medaka fish described in (1) in test water, and observing whether or not one or more thrombi are formed in the medaka fish after the raising step.

    摘要翻译： （1）引入具有由序列号1表示的211〜1935位置的碱基序列的多核苷酸的转基因aka鱼，（2）一种制备具有一个或多个血栓的aka鱼的方法，其包括： （1）中描述的在雌激素存在下的转基因aka鱼，（3）通过（2）中描述的方法制备的具有一种或多种血栓的楝树鱼，和（4）一种测试雌激素样作用物质的方法，包括 （1）中描述的转基因aka鱼在试验水中的步骤，并且观察在升高步骤之后是否在aka鱼中形成一个或多个血栓。

    Fish hatching method and apparatus
    7.
    发明申请
    Fish hatching method and apparatus 有权
    鱼孵化方法和装置

    公开(公告)号：US20040013608A1

    公开(公告)日：2004-01-22

    申请号：US10454821

    申请日：2003-06-05

    发明人： Tommy R. Shedd ,  Mark W. Widder ,  Eugene Hull

    IPC分类号： A61K049/00

    CPC分类号： G01N33/5088 ,  G01N33/5014 ,  G01N2520/00

    摘要： The invention is a method and kit for conducting a rapid toxicity test. Methods and kits according to the invention include an animal or plant species in diapause.

    摘要翻译： 本发明是用于进行快速毒性试验的方法和试剂盒。 根据本发明的方法和试剂盒包括滞育期间的动物或植物物种。

    Assessment of ecosystem health by evaluating multiple biomarkers in a nonhuman organism
    8.
    发明申请
    Assessment of ecosystem health by evaluating multiple biomarkers in a nonhuman organism 审中-公开
    通过评估非人类生物体中的多种生物标志物来评估生态系统健康

    公开(公告)号：US20030138812A1

    公开(公告)日：2003-07-24

    申请号：US10251093

    申请日：2002-09-20

    发明人： Craig A. Downs

    IPC分类号： A61K049/00 ,  A61K031/00 ,  A01N061/00 ,  C12Q001/70 ,  C12Q001/68

    CPC分类号： C12Q1/00 ,  G01N33/50 ,  G01N2520/00

    摘要： A novel method for assessing the health of an ecosystem is provided. The method comprises measuring the levels of a plurality of physiological parameters of a nonhuman organism living in the ecosystem and determining whether the organism is healthy or physiologically stressed based on the levels of the tested physiological parameters. To the extent that the organism is physiologically stressed, the results of the measurement are employed to assess the type and degree of stress occurring in the ecosystem.

    摘要翻译： 提供了一种评估生态系统健康的新方法。 该方法包括测量生活在生态系统中的非人体生物体的多个生理参数的水平，并基于测试的生理参数的水平确定生物体是健康还是生理应激。 在有机体受生理应激的情况下，测量结果用于评估生态系统中发生的应激的类型和程度。

    Tissue-based water quality biosensors for detecting chemical warfare agents
    9.
    发明授权
    Tissue-based water quality biosensors for detecting chemical warfare agents 有权
    用于检测化学战剂的组织水质生物传感器

    公开(公告)号：US06569384B2

    公开(公告)日：2003-05-27

    申请号：US09773641

    申请日：2001-01-31

    申请人： Elias Greenbaum ,  Charlene A. Sanders

    发明人： Elias Greenbaum ,  Charlene A. Sanders

    IPC分类号： G01N1506

    CPC分类号： G01N33/5097 ,  C12Q1/02 ,  G01N2021/635 ,  G01N2520/00

    摘要： A water quality sensor for detecting the presence of at least one chemical or biological warfare agent includes: a cell; apparatus for introducing water into the cell and discharging water from the cell adapted for analyzing photosynthetic activity of naturally occurring, free-living, indigenous photosynthetic organisms in water; a fluorometer for measuring photosynthetic activity of naturally occurring, free-living, indigenous photosynthetic organisms drawn into the cell; and an electronics package that analyzes raw data from the fluorometer and emits a signal indicating the presence of at least one chemical or biological warfare agent in the water.

    摘要翻译： 用于检测至少一种化学或生物战剂的存在的水质传感器包括：电池; 将水引入细胞并从适用于分析水中天然存在的，自由生活的本地光合生物的光合作用的细胞中排出水的装置; 用于测量被吸入细胞的天然存在的，自由生活的本地光合生物的光合作用的荧光计; 以及分析来自荧光计的原始数据并发出指示在水中存在至少一种化学或生物战剂的信号的电子封装。