利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

88 条记录 (耗时 0.033 秒)

    METHOD FOR MAKING MULTISPECIFIC ANTIBODIES HAVING HETEROMULTIMERIC AND COMMON COMPONENTS
    1.
    发明申请
    METHOD FOR MAKING MULTISPECIFIC ANTIBODIES HAVING HETEROMULTIMERIC AND COMMON COMPONENTS 审中-公开
    制备具有异源性和共同成分的多重抗体的方法

    公开(公告)号：US20140322756A1

    公开(公告)日：2014-10-30

    申请号：US14142663

    申请日：2013-12-27

    申请人： GENENTECH, INC.

    发明人： W. Robert ARATHOON ,  Paul J. CARTER ,  Anne M. MERCHANT ,  Leonard G. PRESTA

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2863 ,  A61K38/00 ,  C07K1/22 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/46 ,  C07K16/468 ,  C07K2317/732 ,  Y10S435/972

    摘要： The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras. The invention also relates to the heteromultimers prepared using the method. Generally, the method provides a multispecific antibody having a common light chain associated with each heteromeric polypeptide having an antibody binding domain. Additionally the method further involves introducing into the multispecific antibody a specific and complementary interaction at the interface of a first polypeptide and the interface of a second polypeptide, so as to promote heteromultimer formation and hinder homomultimer formation; and/or a free thiol-containing residue at the interface of a first polypeptide and a corresponding free thiol-containing residue in the interface of a second polypeptide, such that a non-naturally occurring disulfide bond is formed between the first and second polypeptide. The method allows for the enhanced formation of the desired heteromultimer relative to undesired heteromultimers and homomultimers.

    摘要翻译： 本发明涉及制备异源多聚体多肽如双特异性抗体，双特异性免疫粘附素和抗体免疫粘附素嵌合体的方法。 本发明还涉及使用该方法制备的异源多聚体。 通常，该方法提供具有与具有抗体结合结构域的每个异聚多肽相关联的共同轻链的多特异性抗体。 另外，该方法还包括将多特异性抗体引入第一多肽的界面处的第二多肽的界面上的特异性和互补相互作用，以促进异源多聚体形成并阻碍同源多聚体形成; 和/或在第二多肽的界面处的第一多肽和相应的游离含硫醇残基的界面处的游离含硫醇残基，使得在第一和第二多肽之间形成非天然存在的二硫键。 该方法允许相对于不想要的异多元反应物和同源多聚体增强所需异源多聚体的形成。

    Binary or polynary targeting and uses thereof
    6.
    发明申请
    Binary or polynary targeting and uses thereof 有权
    二进制或多重定位及其用途

    公开(公告)号：US20040033519A1

    公开(公告)日：2004-02-19

    申请号：US10427755

    申请日：2003-04-30

    发明人： Lawrence M. Kauvar

    IPC分类号： C12Q001/68

    CPC分类号： B82Y5/00 ,  B82Y10/00 ,  G01N33/542 ,  Y10S435/972

    摘要： Effector functions are provided to a desired target with improved specificity by use of two or more complementary targeting components. The targeting components assemble a functional moiety at the target. At the target, the functional moiety itself provides an effector function or binds to additional components which provide an effector function. The effector function may be an enzymatic activity, a label or a signal. The binary or polynary targeting system may be used for analyte determination as well.

    摘要翻译： 通过使用两种或更多种互补靶向组分，通过改善的特异性将效应功能提供给期望的靶。 靶向组分在靶标上组装功能部分。 在靶标上，功能部分本身提供效应子功能或结合提供效应子功能的其它成分。 效应子功能可以是酶活性，标记或信号。 二进制或多重靶向系统也可用于分析物测定。

    AGP-antibody fusion proteins and related molecules and methods
    7.
    发明授权
    AGP-antibody fusion proteins and related molecules and methods 失效
    AGP抗体融合蛋白及相关分子及方法

    公开(公告)号：US06613746B1

    公开(公告)日：2003-09-02

    申请号：US08472888

    申请日：1995-06-07

    申请人： Brian Seed ,  Gerd Walz

    发明人： Brian Seed ,  Gerd Walz

    IPC分类号： A01N4304

    CPC分类号： C07K16/2854 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/70564 ,  C07K14/70596 ,  C07K16/00 ,  C07K2317/41 ,  C07K2319/00 ,  Y10S435/972

    摘要： Disclosed is a method of inhibiting the binding of a cell bearing a cell adhesion protein to a molecule or cell bearing a carbohydrate determinant specific for the cell adhesion molecule. The method involves contacting the cell adhesion protein-bearing cell with an AGP-antibody bearing the carbohydrate determinant. Also disclosed are AGP-antibody fusion proteins to which are covalently bonded carbohydrate moieties which interfere with the antibody portion's ability to fix complement and bind an Fc receptor. The methods of the invention may be used, for example, in any antibody-based therapy, for example, to reduce inflammation.

    摘要翻译： 公开了抑制携带细胞粘附蛋白的细胞与具有细胞粘附分子特异性的碳水化合物决定簇的分子或细胞的结合的方法。 该方法包括使携带细胞粘附蛋白的细胞与携带碳水化合物决定簇的AGP-抗体接触。 还公开了AGP-抗体融合蛋白，其是共价键合的碳水化合物部分，其干扰抗体部分固定补体并结合Fc受体的能力。 本发明的方法可以用于例如任何基于抗体的治疗中，例如，以减少炎症。

    Monospecific antibody reactive with Fibrinogen and fibrinopeptide B
    9.
    发明授权
    Monospecific antibody reactive with Fibrinogen and fibrinopeptide B 失效
    与纤维蛋白原和纤维蛋白肽B反应的单特异性抗体

    公开(公告)号：US5876947A

    公开(公告)日：1999-03-02

    申请号：US900660

    申请日：1997-07-25

    申请人： Bohdan J. Kudryk ,  Colvin M. Redman ,  Jian-Zhong Zhang

    发明人： Bohdan J. Kudryk ,  Colvin M. Redman ,  Jian-Zhong Zhang

    IPC分类号： C07K16/18 ,  C12P21/08 ,  G01N33/86 ,  G01N33/53 ,  C07K16/36 ,  G01N33/536 ,  G01N33/543

    CPC分类号： C07K16/18 ,  G01N33/86 ,  Y10S435/972 ,  Y10S435/975

    摘要： The invention provides monospecific antibodies that are specifically reactive with fibrinopeptide B (FPB) and with fibrinogen and fragments thereof containing the amino acid sequence defined by SEQ ID NO:1. The invention also provides anti-FPB probes, including monospecific anti-FPB antibodies that have been detectably labeled. In addition, the invention provides methods of using the monospecific antibodies for detection of fibrinopeptide B, as well as reagents and kits for performing the methods. For example, the invention provides a method for detecting fibrinopeptide B with specificity in biological samples such as blood samples, by using the antibody to immunometrically bind to the fibrinopeptide B. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis. The invention further provides continuous cell lines (hybridomas) that produce monospecific anti-FPB antibodies.

    摘要翻译： 本发明提供了与纤维蛋白肽B（FPB）特异性反应的单特异性抗体以及含有由SEQ ID NO：1定义的氨基酸序列的纤维蛋白原及其片段。 本发明还提供抗FPB探针，包括可检测标记的单特异性抗FPB抗体。 此外，本发明提供了使用单特异性抗体检测纤维蛋白肽B的方法，以及用于进行该方法的试剂和试剂盒。 例如，本发明提供了通过使用免疫结合纤维蛋白肽B的抗体来检测生物样品例如血液样品中特异性的纤维蛋白肽B的方法。用于确定与动脉粥样化形成和/或血栓形成相关的信息的诊断方法。 本发明还提供产生单特异性抗FPB抗体的连续细胞系（杂交瘤）。