公开(公告)号：US12102082B2

公开(公告)日：2024-10-01

申请号：US16482920

申请日：2018-02-07

申请人： Koppert B.V.

发明人： Arend Veenman

IPC分类号： A01M9/00 ,  A01G9/14 ,  A01G13/10 ,  A01N63/00 ,  B05B3/02 ,  B05B5/03 ,  B05B5/16 ,  B05B7/00 ,  A01K67/033 ,  A01M7/00 ,  A01N63/16

CPC分类号： A01M9/0007 ,  A01G9/14 ,  A01G13/10 ,  A01N63/00 ,  B05B3/02 ,  B05B5/032 ,  B05B5/1683 ,  B05B7/0081 ,  A01K67/033 ,  A01M7/0025 ,  A01N63/16

摘要： The present invention relates to a method for distributing particulate material in a target area. The method comprises the steps of (i) providing in a reservoir particulate material comprising particles to be distributed in a target area, which reservoir is provided with exits, (ii) providing a gas displacer, (iii) generating with the gas displacer a forced gas flow in the blow direction, and iv) directing the particles from the exits in the forced gas flow. The invention further relates to a device for performing the method according to the invention. Further aspects of the invention relate to the use of the device for distributing particulate material, a gas flow modification device, the use of such modification device for modifying the gas flow in a device for distributing particulate material and a kit of parts comprising (a) the gas flow modification device and (b) a device for distributing particulate material.

公开(公告)号：US12090177B2

公开(公告)日：2024-09-17

申请号：US16251124

申请日：2019-01-18

申请人： Mehrdad Noruzinia ,  Oranous Bashti Shiraz

发明人： Mehrdad Noruzinia ,  Oranous Bashti Shiraz

IPC分类号： C12N5/00 ,  A61K9/00 ,  A61K35/13 ,  A61K35/545 ,  C12N5/02 ,  C12N5/074 ,  A01N63/00 ,  A61P15/02 ,  A61P25/28 ,  A61P35/00

CPC分类号： A61K35/545 ,  A61K9/0019 ,  A61K35/13 ,  C12N5/0607 ,  A61P15/02 ,  A61P25/28 ,  A61P35/00

摘要： A method for modifying gene expression of diseased cells in a patient including preparing an extract of diseased cells, forming a plurality of conditioned stem cells by treating a plurality of normal stem cells with a solution of the extract of the diseased cells with a volume ratio between 10−15 volume/volume (v/v) and 10−3 v/v (volume of the extract of the diseased cells/volume of a culture medium), forming a conditioned stem cell-derived extract, and forming a plurality of healthy cells by treating the diseased cells with the conditioned stem cell-derived extract.

公开(公告)号：US20240225009A1

公开(公告)日：2024-07-11

申请号：US18041366

申请日：2021-07-28

申请人： SPECIALITY OPERATIONS FRANCE

发明人： Monique Adamy ,  Florence Lambert

IPC分类号： A01N63/00 ,  A01N25/10 ,  A01N43/16 ,  A01N65/20 ,  A01P3/00

CPC分类号： A01N63/00 ,  A01N25/10 ,  A01N43/16 ,  A01N65/20 ,  A01P3/00

摘要： The present invention relates to a composition comprising at least one beneficial microorganism and at least one guar gum. It relates more especially to the use of at least one guar gum as a rainfastness agent in a composition comprising at least one beneficial microorganism.

公开(公告)号：US11999942B2

公开(公告)日：2024-06-04

申请号：US18197001

申请日：2023-05-12

申请人： Kerry Group Services International Limited

发明人： Benjamin George ,  Howard Cash ,  Joseph M. Bradley ,  Nusair Imam ,  Stephen G. Cobbe ,  Eileen O'Shea

IPC分类号： A01N63/00 ,  A23L2/52 ,  A23L33/135 ,  C12N1/20 ,  C12R1/07

CPC分类号： C12N1/20 ,  A23L2/52 ,  A23L33/135 ,  C12N1/205 ,  A23V2002/00 ,  C12R2001/07

摘要： A method for preparing a shelf stable spore-containing probiotic alimentary additive is disclosed, the method including providing a liquid slurry including spores from at least one spore-forming probiotic bacterial strain, a saccharide, and a humectant; and pasteurizing the liquid slurry to yield the alimentary additive. The alimentary additive may have a water activity (Aw) of less than about 0.7. The alimentary additive may have a pH from about 2.0 to 9.5. A plurality of the spores may remain in an un-germinated state and uniformly suspended for at least two months after the pasteurizing to yield a shelf stable spore-containing probiotic alimentary additive.

公开(公告)号：US11898158B2

公开(公告)日：2024-02-13

申请号：US16842139

申请日：2020-04-07

申请人： Sangamo Therapeutics, Inc.

发明人： Edward J. Rebar

IPC分类号： A01N63/00 ,  C12N15/90 ,  C12N9/22 ,  A61K38/46 ,  A61K38/47 ,  A61K35/407 ,  A61K48/00

CPC分类号： C12N15/907 ,  A61K35/407 ,  A61K38/465 ,  A61K38/47 ,  A61K48/005 ,  C12N9/22 ,  C12Y301/06013 ,  C12Y302/0102 ,  C12Y302/01021 ,  C12Y302/01022 ,  C12Y302/01076 ,  A61K48/00 ,  C07K2319/81

摘要： Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease.

公开(公告)号：US11820992B2

公开(公告)日：2023-11-21

申请号：US17084279

申请日：2020-10-29

申请人： Plant Health Care, Inc.

发明人： Zhongmin Wei ,  Gregory A. Zornetzer ,  Stephen Bornick

IPC分类号： C12N15/82 ,  A01N63/50 ,  A01N63/10 ,  A01N63/00 ,  A01N37/46 ,  C07K14/00 ,  A01N25/02 ,  A01N25/12 ,  A01N37/22 ,  A01N43/36 ,  A01N43/54 ,  A01N43/90 ,  A01N47/44 ,  A01N51/00 ,  C07K7/08 ,  C07K14/415 ,  C07K14/195 ,  C07K14/24 ,  C07K14/27

CPC分类号： C12N15/8279 ,  A01N25/02 ,  A01N25/12 ,  A01N37/22 ,  A01N37/46 ,  A01N43/36 ,  A01N43/54 ,  A01N43/90 ,  A01N47/44 ,  A01N51/00 ,  A01N63/00 ,  A01N63/10 ,  A01N63/50 ,  C07K7/08 ,  C07K14/001 ,  C07K14/195 ,  C07K14/24 ,  C07K14/27 ,  C07K14/415 ,  C12N15/8283 ,  C07K2319/00 ,  C07K2319/20 ,  A01N63/10 ,  A01N25/02 ,  A01N63/50 ,  A01N63/20 ,  A01N63/50 ,  A01N63/20 ,  A01N25/02

摘要： Disclosed are hypersensitive-response eliciting peptides that exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post-harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.

公开(公告)号：US11819027B2

公开(公告)日：2023-11-21

申请号：US16930020

申请日：2020-07-15

申请人： INDIGO AG, INC.

发明人： Slavica Djonovic ,  Elizabeth Alexa McKenzie ,  Gerardo Toledo ,  Craig Sadowski ,  Geoffrey Von Maltzahn ,  Karen V. Ambrose ,  Xuecheng Zhang ,  David Morris Johnston ,  Trudi A. Gulick

IPC分类号： A01N63/28 ,  A01C1/06 ,  A01H17/00 ,  A01N63/30 ,  A01N63/00 ,  A01G7/00 ,  A01G22/40 ,  A01G22/20

CPC分类号： A01N63/28 ,  A01C1/06 ,  A01G7/00 ,  A01H17/00 ,  A01N63/00 ,  A01N63/30 ,  A01G22/20 ,  A01G22/40

摘要： This invention relates to methods and compositions for providing a benefit to a plant by associating the plant with a beneficial endophyte of the genus Streptomyces, including benefits to a plant derived from a seed or other plant element treated with said endophyte. For example, this invention provides purified endophytes, synthetic combinations comprising endophytes, and methods of making and using the same. In particular, this invention relates to compositions and methods of improving soybean and maize plants.

公开(公告)号：US20230292767A1

公开(公告)日：2023-09-21

申请号：US18295047

申请日：2023-04-03

申请人： CORTEVA AGRISCIENCE LLC

发明人： KAREN E BROGLIE ,  KEVIN KRISS ,  ALBERT LU ,  MANI MUTHALAGI ,  JAMES K. PRESNAIL

IPC分类号： A01N63/60 ,  C12N15/82 ,  A01N63/00 ,  A01N57/16 ,  A01N65/20 ,  A01N65/44 ,  C12N15/113

CPC分类号： A01N63/60 ,  C12N15/8218 ,  C12N15/8286 ,  A01N63/00 ,  A01N57/16 ,  A01N65/20 ,  A01N65/44 ,  C12N15/113 ,  C12N2310/531 ,  Y02A40/146 ,  C12N2310/11

摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D. undecimpunctata howardi. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

公开(公告)号：US11738053B2

公开(公告)日：2023-08-29

申请号：US16329915

申请日：2017-09-01

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Senlin Li ,  Robert A Clark ,  Cang Chen ,  Yang Li

IPC分类号： A01N63/00 ,  C12N15/63 ,  C07H21/04 ,  A61K35/28 ,  A61K38/19 ,  A01K67/027 ,  C12N15/86

CPC分类号： A61K35/28 ,  A01K67/0276 ,  A61K38/193 ,  C12N15/86 ,  A01K2227/105 ,  A01K2267/0306 ,  C12N2740/16043

摘要： The invention relates to a method of treating chronic granulomatous disease through Hematopoietic stem cell (HSC) transplantation. The method comprises the steps of administering stem cell mobilization agent to human such that the target stem cell population migrates from host niches into the subject's blood. The target stem cells are removed from blood and administering the therapeutic stem cells to human and said therapeutic stem cells are engineered to express gp91phox. The steps are repeated multiple times i.e. at least four times. The mobilization agents used in the invention are granulocyte-colony stimulating factor and AMD3100. The method of HSC transplantation is effective in treatment of chronic granulomatous disease.

公开(公告)号：US11730775B2

公开(公告)日：2023-08-22

申请号：US17222778

申请日：2021-04-05

申请人： Seres Therapeutics, Inc.

发明人： Gregory McKenzie ,  Mary-Jane Lombardo McKenzie ,  David N. Cook ,  Marin Vulic ,  Geoffrey Von Maltzahn ,  Brian Goodman ,  John Grant Aunins ,  Matthew R. Henn ,  David Arthur Berry ,  Jonathan Winkler

IPC分类号： A01N63/00 ,  A61K35/741 ,  A61K9/00 ,  A61K45/06 ,  A61K9/48 ,  C12N1/20 ,  A61K35/74 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K35/37

CPC分类号： A61K35/741 ,  A61K9/0053 ,  A61K9/48 ,  A61K9/4816 ,  A61K35/37 ,  A61K35/74 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K45/06 ,  C12N1/20 ,  Y02A50/30

摘要： Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.