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    DETECTION OF EARLY-STAGE LUNG CANCER IN SPUTUM USING AUTOMATED FLOW CYTOMETRY AND MACHINE LEARNING
    1.
    发明申请
    DETECTION OF EARLY-STAGE LUNG CANCER IN SPUTUM USING AUTOMATED FLOW CYTOMETRY AND MACHINE LEARNING 有权

    公开(公告)号：US20250069747A1

    公开(公告)日：2025-02-27

    申请号：US18745375

    申请日：2024-06-17

    Applicant: bioAffinity Technologies, Inc.

    Inventor： Vivienne I. Rebel ,  Madeleine E. Lemieux

    IPC: G16H50/20 ,  A61B10/00 ,  G01N15/14 ,  G01N15/1429 ,  G16B40/20

    Abstract: A system and method for analyzing a sputum sample from a subject suspected of having lung cancer comprising obtaining a plurality of cells from the sputum sample from the subject, marking the plurality of cells with i) a plurality of cell lineage specific marker compositions, ii) a cell viability composition and iii) a tetra (4-carboxyphenyl) porphyrin (TCPP) composition; analyzing with the flow cytometer the plurality of cells marked with i-iii to obtain a subpopulation selected for cell size from the plurality of cells based upon an automatically selected bead size exclusion gate; from the cell size selected subpopulation, selecting a viable singlet population of cells using an automated non-debris gate and an automated singlets gate; from the viable singlet population of cells, obtaining flow cytometer values based upon the plurality of cell lineage specific marker compositions, the viability marker and the TCPP marker; applying a trained classifier to meta data from the subject and the flow cytometric values obtained; and generating, based upon the application of the trained classifier, a classification for the sputum sample wherein the classification is selected from a plurality of classification options comprising cancer and non-cancer.

    EPIDURAL NEEDLE
    2.
    发明申请
    EPIDURAL NEEDLE 有权

    公开(公告)号：US20250064431A1

    公开(公告)日：2025-02-27

    申请号：US18454863

    申请日：2023-08-24

    Applicant: Imam Abdulrahman Bin Faisal University

    Inventor： Murad ALTHOBAITI ,  Nasir Ghazi HARIRI ,  Sajid ALI ,  Kamran HAMEED ,  Naif Adnan AL-RUBAI

    IPC: A61B10/00 ,  A61B17/34

    Abstract: An epidural needle with a mechanism to receive real-time feedback on the location of the epidural needle during insertion process of the epidural needle. In particular, the epidural needle includes a spring and a pair of needles coupled to a force-measuring sensor for a continuous measurement of the force at a tip of the epidural needle as the epidural needle is inserted. The spring is enclosed in a spring section between a lug section and a needle section. The lug section comprises the force-measuring sensor and the needle section comprises a needle to be inserted. The lug section, the spring section and the needle section are axially aligned along an epidural needle axis. A force is transmitted from the needle section through the spring of the spring section to the force-measuring sensor of the lug section.

    ULTRASOUND METHODS AND DEVICES FOR ENHANCING CYTOPATHOLOGIC CELL COLLECTION
    5.
    发明申请
    ULTRASOUND METHODS AND DEVICES FOR ENHANCING CYTOPATHOLOGIC CELL COLLECTION 有权

    公开(公告)号：US20250057469A1

    公开(公告)日：2025-02-20

    申请号：US18938557

    申请日：2024-11-06

    Applicant: Adenocyte Ltd.

    Inventor： Mark RUTENBERG ,  Dan ADAM ,  Kyle MORRISON

    IPC: A61B5/00 ,  A61B10/00 ,  A61B17/00 ,  A61B17/22

    Abstract: A method of producing cytopathologic cell samples, the method including insonating a target tissue by ultrasound energy with a focused beam at that generates shear waves within the tissue. A method of producing cytopathologic cell samples, the method including insonating a target tissue by ultrasound energy at a first intensity level during a first period, insonating the target tissue by ultrasound energy at a second intensity level during a second period, wherein the first intensity level is higher than the second intensity level. Related apparatus and methods are also described.

    Biopsy device with applied imaging
    6.
    发明授权
    Biopsy device with applied imaging 有权

    公开(公告)号：US12220114B2

    公开(公告)日：2025-02-11

    申请号：US17852633

    申请日：2022-06-29

    Applicant: Devicor Medical Products, Inc.

    Inventor： Bryan R. Keller ,  Patrick A. Mescher

    IPC: A61B10/02 ,  A61B10/00 ,  A61B90/00 ,  A61B10/04

    Abstract: A biopsy device includes a body, a needle, a tissue sample holder and a sensor. The needle extends from the body. The tissue sample holder is in communication with the needle to receive one or more tissue samples within a sample chamber defined by the tissue sample holder. The tissue sample holder includes a receiving cavity. The sensor is configured to detect x-rays. The receiving cavity is sized and shaped to receive the sensor such that the sensor is removably positioned within the tissue sample holder.

    Multi-stage oral-fluid testing device with cap containing plunger for oral-fluid release from collection sponge
    8.
    发明授权
    Multi-stage oral-fluid testing device with cap containing plunger for oral-fluid release from collection sponge 有权

    公开(公告)号：US12214345B2

    公开(公告)日：2025-02-04

    申请号：US17403013

    申请日：2021-08-16

    Applicant: Premier Biotech, LLC

    Inventor： Kevin S. Fuller ,  Wayde J. Altendorf ,  Todd Bailey

    IPC: G01N33/487 ,  A61B10/00 ,  B01L3/00

    Abstract: In an embodiment, the claimed invention includes an oral-fluid collection and testing device that. is simple to operate. The device includes a body assembly and a cap assembly that are easy to handle by a user. A collection sponge projects from an end of the body assembly for absorbing the oral fluid of a donor, A cap assembly is easily aligned with the body assembly by way of visual alignment indicators on both the body and the cap. Once the cap is aligned with the body, a user simply pushes the cap onto the ‘body, which causes a first stage fluid, flow. More specifically, a buffer fluid is released from the cap and mixes with the oral fluid collected on the sponge—After waiting a short time* the cap is rotated, then pushed again, causing a second-stage fluid flow in which the sponge is compressed such that the buffer fluid/oral fluid exits the sponge and flows toward a. pair of test strips. A user can then easily view the test results by observing a visual indication, such as a color change of the test strips through a viewing window.

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