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    Amines as ant-alcoholism agents
    1.
    发明申请
    Amines as ant-alcoholism agents 失效
    胺类作为抗酗酒剂

    公开(公告)号：US20040242701A1

    公开(公告)日：2004-12-02

    申请号：US10489251

    申请日：2004-03-11

    发明人： Norberto Bilbeny Lojo ,  Hernan Garcia Madrid

    IPC分类号： A61K031/13

    CPC分类号： A61K31/132

    摘要： The oral administration to genetically alcoholic rats (from the strain UChB of the University of Chile) of a compound selected from endogenic polyamines (putrescine, spermidine, spermine), 1,3-propanediamine, their pharmaceutically acceptable salts and solvates, and their bioprecursor amides, causes a significant reduction in the alcohol consumption. The activity lasts for some time after the treatment period. Besides, there is a virtually null disulfiram-like adverse effect, what constitutes an advantage over the unpleasant use of some anti-alcoholism agents, such as calcium cyanamide or disulfiram itself. Therefore, the compounds of the invention are useful for the preparation of medicaments for the therapeutic and/or prophylactic treatment of alcoholism in human beings.

    摘要翻译： 对选自内源性多胺（腐胺，亚精胺），1,3-丙二胺，其药学上可接受的盐和溶剂化物的化合物及其生物前体酰胺的基因酒精大鼠（来自智利大学的UCHB菌株）进行口服给药 ，导致酒精消费量显着降低。 治疗期间活动持续一段时间。 此外，存在几乎无效的双硫仑样副作用，与某些抗酒精中毒药如氨基氰胺氰胺或双硫仑本身不利的使用相比，具有什么优势。 因此，本发明的化合物可用于制备用于治疗和/或预防人类酒精中毒的药物。

    Immunomodulation with novel pharmaceutical compositions
    2.
    发明申请
    Immunomodulation with novel pharmaceutical compositions 失效
    用新型药物组合物进行免疫调节

    公开(公告)号：US20040235960A1

    公开(公告)日：2004-11-25

    申请号：US10443743

    申请日：2003-05-23

    发明人： Mark R. Burns ,  Maralee McVean ,  Kevin J. Kennedy ,  Arthur Yeung ,  Bruce H. Devens

    IPC分类号： A61K031/137 ,  A61K031/13 ,  C07C211/57 ,  C07C211/16

    CPC分类号： C07C211/30 ,  C07D215/12 ,  C07D217/14 ,  C07D307/52 ,  C07D333/20

    摘要： The synthesis and use of a novel class of tumor necrosis factor (TNFnull) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNFnull and other involved cytokines. As pharmaceuticals, these compounds are used to treat inflammatory, infectious, autoimmune or other proliferative diseases and conditions related to the unwanted presence or activity of TNFnull and/or one or more other involved cytokines, alone or in combination with other agents. Examples of compounds of the present invention are those having the structures as shown below: 1 wherein, a, b and c may be the same or different and are integers from 0 to 12, X equals NH or CHNH2, R1 and R2 can be the same or different and equal to a hydrogen or a straight or branched C1 to C20 saturated or unsaturated aliphatic; aliphatic amine; an alicyclic; single or multi-ring aromatic; a single or multi-ring aromatic heterocycle; a single or multi-ring saturated heterocycle and the halogenated forms thereof; and 2 wherein, a, b and c may be the same or different and are integers from 0 to 12; R1, R2, R3, and R4 can be the same or different and equal to a hydrogen or a straight or branched C1 to C20 saturated or unsaturated aliphatic; aliphatic amine; an alicyclic; single or multi-ring aromatic; a single or multi-ring aromatic heterocycle; a single or multi-ring saturated heterocycle and the halogenated forms thereof.

    摘要翻译： 提供新型肿瘤坏死因子（TNFalpha）抑制剂和免疫调节剂的合成和使用。 这些化合物具有药理学应用以及与TNFα和其他涉及细胞因子相关的测定中的应用。 作为药物，这些化合物用于单独或与其它药剂组合治疗与TNFα和/或一种或多种其它涉及的细胞因子的不期望的存在或活性有关的炎性，感染性，自身免疫性或其它增殖性疾病和病症。 本发明化合物的实例是具有如下结构的那些：其中a，b和c可以相同或不同，为0至12的整数，X等于NH或CHNH 2，R 1和R 2可以相同 或不同且等于氢或直链或支链C 1至C 20饱和或不饱和脂族基; 脂肪胺; 脂环族 单环或多环芳香族; 单环或多环芳族杂环; 单环或多环饱和杂环及其卤化形式; 并且其中a，b和c可以相同或不同，为0至12的整数; R 1，R 2，R 3和R 4可以相同或不同，并且等于氢或直链或支链C 1至C 20饱和或不饱和脂族基; 脂肪胺; 脂环族 单环或多环芳香族; 单环或多环芳族杂环; 单环或多环饱和杂环及其卤化形式。

    Polyamine compounds and compositions for use in conjunction with cancer therapy
    4.
    发明申请
    Polyamine compounds and compositions for use in conjunction with cancer therapy 有权
    用于与癌症治疗结合使用的多胺化合物和组合物

    公开(公告)号：US20040225021A1

    公开(公告)日：2004-11-11

    申请号：US10847236

    申请日：2004-05-17

    申请人： Wisconsin Alumni Research Foundation

    发明人： William E. Fabl ,  Richard R. Copp JR. ,  Cynthia E. Ochsner ,  Daniel D. Peebles ,  Kathleen L. Fahl

    IPC分类号： A61K031/13

    CPC分类号： C07C323/25 ,  C07C211/14 ,  C07C211/22 ,  C07C215/18 ,  C07C215/24 ,  C07C323/27

    摘要： The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chemoprotective polyamines formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.

    摘要翻译： 本发明提供新的多胺化合物和用于与癌症化学疗法或放射治疗相结合的药物组合物。 化合物在局部施用以提供防止化学疗法或放射治疗（例如秃发，粘膜炎和皮炎）的不良副作用的保护。 公开了包含一种或多种配制用于局部或局部递送至上皮或粘膜细胞的化学保护性多胺的药物制剂。 还公开了施用药物制剂的方法。

    Chloramine T based teat cleaner and related process
    5.
    发明申请
    Chloramine T based teat cleaner and related process 有权
    氯胺T型奶头清洁剂及相关工艺

    公开(公告)号：US20040225017A1

    公开(公告)日：2004-11-11

    申请号：US10833431

    申请日：2004-04-28

    发明人： Charles A. Schneider

    IPC分类号： A61K031/13

    CPC分类号： A01N59/00 ,  A01N41/06

    摘要： Dairy animals have been milked since prehistory. Because these dairy animals are often kept in confined areas the teat areas of these animals are often contaminated with bacteria. This invention is concerned with a process for sanitizing these contaminated teat areas by treating these areas with a solution of Chloramine T. The preferred solutions for sanitizing the teat areas have concentrations of from about 0.005 to about 1 weight percent. Treating solutions for use in this invention may further incorporate a coloring agents, wetting agent, surfactants, healing agents, dyes, thickening agents, skin conditioning agents, softeners etc. The process of this invention is fast acting and is effective against a wide spectrum of bacteria. After treatment the teat area of the dairy animal being milked is bacteria free and hence bacterial contamination of the milk, and Mastitis infections are eliminated.

    摘要翻译： 自从史前史以来，奶牛已经挤奶了。 因为这些奶牛经常被保存在密闭区域，所以这些动物的乳头区常常被细菌污染。 本发明涉及通过用氯胺T溶液处理这些区域来消毒这些受污染的乳头区域的方法。用于消毒奶头区域的优选溶液具有约0.005至约1重量％的浓度。 用于本发明的治疗溶液可以进一步包含着色剂，润湿剂，表面活性剂，愈合剂，染料，增稠剂，皮肤调理剂，软化剂等。本发明的方法是快速作用的并且对广谱的 菌。 在处理之后，被挤奶的乳制动物的乳头区域是无细菌的，因此牛奶的细菌污染和乳腺炎感染被消除。

    Aerosolized decongestants for the treatment of sinusitis
    6.
    发明申请
    Aerosolized decongestants for the treatment of sinusitis 审中-公开
    用于治疗鼻窦炎的气雾化减充血剂

    公开(公告)号：US20040204399A1

    公开(公告)日：2004-10-14

    申请号：US10835872

    申请日：2004-04-29

    发明人： Robert S. Osbakken ,  Mary Anne Hale ,  Frederick T. Leivo ,  James D. Munk

    IPC分类号： A61K031/55 ,  A61K031/5415 ,  A61K031/495 ,  A61K031/13

    CPC分类号： A61M11/06 ,  A61K9/0043 ,  A61K9/0078

    摘要： Pharmaceutical compositions contain a surfactant and one or more active ingredients selected from among anti-infective agents, anti-inflammatory agents, anti-mucolytic agents, antihistamines, antiseptics, combinations of antibiotics and combinations of these agents. The compositions are formulated for aerosol administration to treat chronic sinusitis or nasal polyps.

    摘要翻译： 药物组合物含有表面活性剂和一种或多种选自抗感染剂，抗炎剂，抗粘液溶解剂，抗组胺剂，防腐剂，抗生素的组合以及这些药物的组合的活性成分。 将组合物配制用于气雾剂给药以治疗慢性鼻窦炎或鼻息肉。

    Treatment of acne using alkonolamine compositions
    8.
    发明申请
    Treatment of acne using alkonolamine compositions 有权
    使用烷醇胺组合物治疗痤疮

    公开(公告)号：US20040185076A1

    公开(公告)日：2004-09-23

    申请号：US10768359

    申请日：2004-01-30

    发明人： Nicholas V. Perricone

    IPC分类号： A61K038/05 ,  A61K031/385 ,  A61K031/198 ,  A61K031/13

    CPC分类号： A61Q19/00 ,  A61K8/0208 ,  A61K8/38 ,  A61K8/41 ,  A61K8/44 ,  A61K8/4986 ,  A61K31/13 ,  A61K31/131 ,  A61K31/133 ,  A61K31/195 ,  A61K31/385 ,  A61K45/06 ,  A61K2800/75 ,  A61Q5/02 ,  A61Q17/00 ,  Y10S514/859 ,  A61K2300/00

    摘要： Acne is treated or prevented by the topical application of compositions containing an alkanolamine such as dimethylaminoethanol, tyrosine, and a sulfur ingredient such as lipoic acid or glutathione. Adjunct ingredients such as fatty acid esters of ascorbic acid, e.g., ascorbyl palmitate and null-hydroxy acids may be included in the formulations. Compositions of the invention may be used alone, or, in many preferable embodiments, in combination with conventional acne medications such as anti-acne products containing salicylic acid, benzoyl peroxide, or a retinoid. In these embodiments, alkanolamine compositions of the invention are applied to affected skin areas first, and then a conventional acne medication is applied. This maximizes the efficacy of the treatment while minimizing skin irritation caused by conventional medications.

    摘要翻译： 通过局部施用含有链烷醇胺如二甲基氨基乙醇，酪氨酸和硫成分如硫辛酸或谷胱甘肽的组合来治疗或预防痤疮。 配方中可以包括辅助成分，例如抗坏血酸的脂肪酸酯，例如棕榈酸抗坏血酸酯和α-羟基酸。 本发明的组合物可以单独使用，或者在许多优选的实施方案中与常规的痤疮药物组合使用，例如含有水杨酸，过氧化苯甲酰或类视色素的抗痤疮产品。 在这些实施方案中，首先将本发明的链烷醇胺组合物施用于受影响的皮肤区域，然后施用常规的痤疮药物。 这使治疗的功效最大化，同时使由常规药物引起的皮肤刺激最小化。

    Medicament containing a polyamine as an active substance
    10.
    发明申请
    Medicament containing a polyamine as an active substance 审中-公开
    含有多胺作为活性物质的药物

    公开(公告)号：US20040077610A1

    公开(公告)日：2004-04-22

    申请号：US10250511

    申请日：2003-06-27

    发明人： Tobias Schlapp ,  Sonja Maria Friederichs ,  Martin Vollmer

    IPC分类号： A61K031/56 ,  A61K031/17 ,  A61K031/13

    CPC分类号： A61K31/785

    摘要： The present invention relates to medicaments which comprise a polyamine as the active substance and to the use of a polyamine for producing immunostimulatory medicaments or medicaments for the treatment and/or prophylaxis of various diseases in humans and animals.

    摘要翻译： 本发明涉及包含多胺作为活性物质的药物，以及使用多胺来制备用于治疗和/或预防人和动物各种疾病的免疫刺激药物或药物。