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190 条记录 (耗时 0.029 秒)

    Popping oral administration form
    4.
    发明申请
    Popping oral administration form 审中-公开
    流行口头表达

    公开(公告)号：US20030235613A1

    公开(公告)日：2003-12-25

    申请号：US10173814

    申请日：2002-06-19

    申请人： CTS Chemical Industries Ltd.

    发明人： Sigal First ,  Rina Yamin

    IPC分类号： A61K009/46 ,  A61K009/14 ,  A61K033/10 ,  A61K031/473 ,  A61K031/24 ,  A61K031/192 ,  A61K031/137

    CPC分类号： A61K9/0095 ,  A61K9/0056

    摘要： Disclosed are popping pharmaceutical oral administration forms, which comprise an active ingredient, and pressurized gas trapped within cavities in a pharmaceutically acceptable material in a manner that allows the gas to escape from the administration form upon dissolution or shattering of said form. Such an oral administration form may be popular with children that will prefer it on other ones, which do not pop. Methods for preparation of such oral administration forms are also disclosed.

    摘要翻译： 本发明公开了一种药物口服给药形式，其包含活性成分，以及在药学上可接受的材料中被捕获在空腔内的加压气体，其允许气体在所述形式的溶解或破碎时从给药形式逸出。 这样一种口头表达式可能会受到不喜欢流行的其他儿童喜欢的儿童的欢迎。 还公开了这种口服给药形式的制备方法。

    Topical synergistic microbicide
    5.
    发明申请
    Topical synergistic microbicide 审中-公开
    局部协同杀微生物剂

    公开(公告)号：US20030176483A1

    公开(公告)日：2003-09-18

    申请号：US10096672

    申请日：2002-03-13

    发明人： Gerald N. Kern

    IPC分类号： A61K031/4178 ,  A61K031/275 ,  A61K031/24 ,  A61K031/195 ,  A61K031/10

    CPC分类号： A61K47/20 ,  A61K9/0014 ,  A61K45/06

    摘要： Application of topical synergistic microbicide composition(s) of high practical utility both as a treatment and/or prevention against HSV Type 1 and/or Type 2 and related diseases and secondary opportunist disease causing agents, while reducing the inflammation, prolonged healing times and reduce scaring.

    摘要翻译： 应用具有高实用效用的局部协同杀微生物剂组合物作为治疗和/或预防HSV 1型和/或2型及相关疾病和次级机会性疾病引发剂，同时减少炎症，延长愈合时间和减少 害怕

    Injectable compositions for the controlled delivery of pharmacologically active compound
    10.
    发明申请
    Injectable compositions for the controlled delivery of pharmacologically active compound 有权
    用于控制递送药理学活性化合物的可注射组合物

    公开(公告)号：US20030130211A1

    公开(公告)日：2003-07-10

    申请号：US10274445

    申请日：2002-10-18

    发明人： Yerramilli V.S.N. Murthy ,  Robert H. Suva

    IPC分类号： A61K031/704 ,  A61K031/496 ,  A61K031/202 ,  A61K031/65 ,  A61K031/63 ,  A61K031/24 ,  A61K031/205

    CPC分类号： A61K31/00 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/24 ,  A61K31/496 ,  A61K31/65 ,  A61K31/7034 ,  A61K31/7048 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K2300/00

    摘要： The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a periods of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.

    摘要翻译： 本发明提供用于延长释放时间并降低药理活性化合物的毒性的组合物和方法。 化合物包含药理活性化合物的盐与亲脂性抗衡离子和药学上可接受的水溶性溶剂组合在一起形成可注射组合物。 亲油抗衡离子可以是饱和或不饱和的C 8 -C 22脂肪酸，优选可以是饱和或不饱和的C 10 -C 18脂肪酸。 当注射到哺乳动物中时，组合物的至少一部分随时间沉淀并释放活性化合物。 因此，组合物在哺乳动物中形成缓慢释放活性化合物的药物贮库。 因此，本发明使得能够提供活性化合物的受控剂量给药长达15天甚至更长时间。 根据本发明可以施用许多化合物，包括但不限于替米考星，土霉素，美托洛尔，氟西汀，罗红霉素和头孢噻吩。