公开(公告)号：US12128138B2

公开(公告)日：2024-10-29

申请号：US17245330

申请日：2021-04-30

申请人： Fertin Pharma A/S

发明人： Helle Wittorff ,  Christine Nøhr Pedersen

IPC分类号： A61K9/16 ,  A61K8/02 ,  A61K8/34 ,  A61K8/37 ,  A61K8/49 ,  A61K9/00 ,  A61K31/191 ,  A61K31/194 ,  A61K33/30 ,  A61K45/06 ,  A61Q11/00

CPC分类号： A61K9/1623 ,  A61K8/022 ,  A61K8/0225 ,  A61K8/345 ,  A61K8/347 ,  A61K8/37 ,  A61K8/498 ,  A61K9/0053 ,  A61K31/191 ,  A61K31/194 ,  A61K33/30 ,  A61K45/06 ,  A61Q11/00 ,  A61K2800/28 ,  A61K2800/41 ,  A61K2800/412 ,  A61K2800/74 ,  A61K2800/92

摘要： A mouthwash and method for oral care benefits includes a swishable powder delivery system having a content of at least two types of sugar alcohol particles with different particle size distributions and one or more active ingredients, the powder delivery system being a dry and flowable population of particles suitable for resembling a liquid mouthwash by swishing the powder delivery system, thereby generating fluid in the oral cavity without adding water.

公开(公告)号：US20240325747A1

公开(公告)日：2024-10-03

申请号：US18621825

申请日：2024-03-29

申请人： NOVOCURE GMBH

发明人： ANAT KLEIN-GOLDBERG ,  ROM PAZ ,  TALI VOLOSHIN-SELA ,  LILACH AVIGDOR

IPC分类号： A61N1/36 ,  A61K31/191 ,  A61P35/00 ,  C07K16/28 ,  G01N33/68

CPC分类号： A61N1/36002 ,  A61K31/191 ,  A61P35/00 ,  C07K16/2896 ,  G01N33/68

摘要： Disclosed are methods of treating a subject in need thereof comprising applying an alternating electric field, at a frequency for a period of time, to a target site of the subject in need thereof; and administering a neural-cadherin (N-cadherin) inhibitor to the subject in need thereof. Disclosed are methods of preventing metastasis comprising applying an alternating electric field, at a frequency for a period of time, to a population of cells comprising one or more cancer cells; and contacting a N-cadherin inhibitor to the population of cells.

公开(公告)号：US20240307278A1

公开(公告)日：2024-09-19

申请号：US18674999

申请日：2024-05-27

申请人： LYCORED LTD.

发明人： Jean KRUTMANN ,  Yoav SHARONI ,  Joseph LEVY ,  Karin LINNEWIEL HERMONI

IPC分类号： A61K8/31 ,  A23L33/15 ,  A61K8/365 ,  A61K9/00 ,  A61K31/015 ,  A61K31/191 ,  A61K31/355 ,  A61Q19/08

CPC分类号： A61K8/31 ,  A23L33/15 ,  A61K8/365 ,  A61K9/0053 ,  A61K31/015 ,  A61K31/191 ,  A61K31/355 ,  A61Q19/08 ,  A61K2800/522 ,  A61K2800/92

摘要： The invention is directed to compositions comprising lycopene and to methods of using the same, such as for improving one or more skin parameters. e.g., prevention or treatment of various skin-related conditions caused by ultraviolet radiation.

公开(公告)号：US20240293346A1

公开(公告)日：2024-09-05

申请号：US18437920

申请日：2024-02-09

申请人： AXCESS GLOBAL SCIENCES, LLC

发明人： Gary MILLET

IPC分类号： A61K31/191 ,  A61K9/00 ,  A61K31/047 ,  A61K45/06

CPC分类号： A61K31/191 ,  A61K9/0095 ,  A61K31/047 ,  A61K45/06

摘要： An energy-promoting composition includes an exogenous ketone body component that provides a source of caloric energy, a vasodilator component, a stimulant component, such as caffeine, and optionally a nootropic component. In most if not all cases, the vasodilator, stimulant, and nootropic components do not themselves provide a source of caloric energy but may increase metabolism of available caloric energy. The separate components beneficially and synergistically interact with one another to enhance the overall energy-promoting effect of the composition more rapidly and to a greater degree than if one or more of the components are omitted. The energy-promoting composition is also formulated to minimize the crash effect common to stimulants such as energy drinks.

公开(公告)号：US20240277773A1

公开(公告)日：2024-08-22

申请号：US18571533

申请日：2022-06-29

申请人： UNIVERSITEIT GENT

发明人： Bernard DEPYPERE ,  Phillip BLONDEEL ,  Ann-Sophie MADELEYN ,  Luc DE BAERDEMAEKER

IPC分类号： A61K35/28 ,  A61K31/19 ,  A61K31/191 ,  A61K33/00 ,  A61K33/06 ,  C12N5/0775

CPC分类号： A61K35/28 ,  A61K31/19 ,  A61K31/191 ,  A61K33/00 ,  A61K33/06 ,  C12N5/0667 ,  C12N2500/30 ,  C12N2509/00

摘要： The present invention relates to the field of medicine, in particular to internal and aesthetic regenerative medicine. More specifically, the present invention relates to a composition suitable for use as a transport medium for adipose tissue and/or cells derived thereof. The invention further relates to a liposuction infiltration formulation and a process to obtain lipoaspirate material.

公开(公告)号：US12064406B2

公开(公告)日：2024-08-20

申请号：US15930532

申请日：2020-05-13

申请人： Pharmosa Biopharm Inc.

发明人： Pei Kan ,  Yi Fong Lin ,  Ko Chieh Chen

IPC分类号： A61K31/192 ,  A61K9/127 ,  A61K31/191 ,  A61P9/12

CPC分类号： A61K31/192 ,  A61K9/127 ,  A61K31/191 ,  A61P9/12

摘要： The present invention relates to a pharmaceutical composition containing liposomes, said liposome comprise an external lipid bilayer; and an internal aqueous medium including a weak acid drug with a half-life of less than 2 hours. Also provided is the use of the pharmaceutical composition disclosed herein to treat pulmonary hypertension with reduced dosing frequency.

公开(公告)号：US20240180897A1

公开(公告)日：2024-06-06

申请号：US18437733

申请日：2024-02-09

申请人： MannKind Corporation

发明人： John J. Freeman ,  Marshall L. Grant ,  Jason J. Antunovich ,  William Elliott Bay

IPC分类号： A61K31/495 ,  A61K9/00 ,  A61K31/191 ,  A61P9/12

CPC分类号： A61K31/495 ,  A61K9/0075 ,  A61K31/191 ,  A61P9/12

摘要： Inhalable compositions for treating pulmonary hypertension comprising treprostinil, derivative thereof or analogs thereof and a method for treating pulmonary arterial hypertension and/or idiopathic pulmonary fibrosis are disclosed herein. Methods of manufacturing pharmaceutical compositions are also disclosed. Compositions are based on diketopiperazine powders for pulmonary inhalation.

公开(公告)号：US11969417B2

公开(公告)日：2024-04-30

申请号：US17419915

申请日：2020-01-28

申请人： TOMORROWLABS GMBH

发明人： Dominik Thor ,  Dominik Duscher

IPC分类号： A61K31/4412 ,  A61K9/00 ,  A61K31/16 ,  A61K31/191 ,  A61K31/4196 ,  A61K31/444 ,  A61P17/14

CPC分类号： A61K31/4412 ,  A61K9/0014 ,  A61K31/16 ,  A61K31/191 ,  A61K31/4196 ,  A61K31/444 ,  A61P17/14

摘要： The invention relates to a composition comprising a HIF-1a activity potentiating agent for use in a method of preventing or treating hair loss, wherein the HIF-1a activity potentiating agent is an iron chelator, preferably Deferiprone. The invention further relates to a composition for topical application, comprising a HIF-1a activity potentiating agent that is an iron chelator. Furthermore, the invention relates to a method for cosmetic treatment or prevention of hair loss, comprising topical application of a composition comprising a HIF-1a activity potentiating agent that is an iron chelator to an area of skin.

公开(公告)号：US20240066086A1

公开(公告)日：2024-02-29

申请号：US18458248

申请日：2023-08-30

申请人： Allergan Sales, LLC

发明人： Tony Wang ,  Kuniko Kadoya ,  Prithwiraj Maitra ,  Rahul Mehta ,  Elizabeth Makino

IPC分类号： A61K36/282 ,  A61K9/00 ,  A61K31/01 ,  A61K31/05 ,  A61K31/075 ,  A61K31/191 ,  A61K31/196 ,  A61K31/197 ,  A61K31/205 ,  A61K31/343 ,  A61K31/351 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4015 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/6615 ,  A61K31/728 ,  A61K31/765 ,  A61K36/03 ,  A61K36/42 ,  A61K36/48 ,  A61K36/73 ,  A61K36/87 ,  A61K36/886 ,  A61K38/07 ,  A61K45/06 ,  A61P17/00

CPC分类号： A61K36/282 ,  A61K9/0014 ,  A61K31/01 ,  A61K31/05 ,  A61K31/075 ,  A61K31/191 ,  A61K31/196 ,  A61K31/197 ,  A61K31/205 ,  A61K31/343 ,  A61K31/351 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4015 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/6615 ,  A61K31/728 ,  A61K31/765 ,  A61K36/03 ,  A61K36/42 ,  A61K36/48 ,  A61K36/73 ,  A61K36/87 ,  A61K36/886 ,  A61K38/07 ,  A61K45/06 ,  A61P17/00

摘要： The present invention relates to topical compositions that can be used to treat melanin or pigmentation disorders and methods of using the compositions.

公开(公告)号：US20240058286A1

公开(公告)日：2024-02-22

申请号：US18500175

申请日：2023-11-02

申请人： VAGINAL BIOME SCIENCE, INC.

发明人： Wendy STRGAR

IPC分类号： A61K31/191 ,  A61K47/36 ,  A61K9/06 ,  A61K9/00 ,  G01N33/50 ,  A61K47/12 ,  A61K47/38 ,  A61K47/02

CPC分类号： A61K31/191 ,  A61K47/36 ,  A61K9/06 ,  A61K9/0034 ,  A61K9/00 ,  G01N33/50 ,  A61K47/12 ,  A61K47/38 ,  A61K47/02

摘要： Vaginal lubricants that have salts which are biomatched to salts that are naturally present in the vagina facilitate intercourse without toxic effects. Topical substances that have a low buffering capacity to promote fertility by providing lubricity while minimizing disturbance to the natural pH levels present during intercourse. A low buffering capacity reduces the extent to which a product interferes with natural pH and buffering capacity of fluids that are present during intercourse.