公开(公告)号：US20240358694A1

公开(公告)日：2024-10-31

申请号：US18764541

申请日：2024-07-05

申请人： G2GBIO, INC.

发明人： Heeyong LEE ,  Eunyoung SEOL ,  Kwonhyeok YOON

IPC分类号： A61K31/445 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61K31/445 ,  A61K9/0019 ,  A61K9/1647

摘要： The present invention relates to a sustained-release injectable preparation comprising biodegradable polymer microspheres containing donepezil as an active ingredient, and a method for producing the same, and a sustained-release preparation of donepezil sustained-release microspheres having a high content of donepezil and a method for producing the same. It is possible to maximize the therapeutic effect by decreasing gastrointestinal side effects frequently encountered in conventional oral administration agents and increasing patients' compliance of medicines.

公开(公告)号：US20240350408A1

公开(公告)日：2024-10-24

申请号：US18675072

申请日：2024-05-27

申请人： RXOS Medical Inc.

发明人： Richard M Millis ,  Jeffrey A Niezgoda ,  Rajagopalan Sridhar

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K31/13 ,  A61K31/15 ,  A61K31/216 ,  A61K31/445 ,  A61K33/38 ,  A61K45/06 ,  A61K47/32 ,  A61L15/32 ,  A61L15/44 ,  A61L15/60

CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/13 ,  A61K31/15 ,  A61K31/216 ,  A61K31/445 ,  A61K33/38 ,  A61K45/06 ,  A61K47/32 ,  A61L15/325 ,  A61L15/44 ,  A61L15/60

摘要： A polyfunctional radical scavenger hydrogel formulation providing extended protection of the extracellular space within a wound site. The polyfunctional radical scavenger hydrogel formulation is generally formed from a hydrogel, a first radical scavenger and a second radical scavenger differing from the first radical scavenger with respect to at least one property. A portion of the first radical scavenger included with the formation and/or second radical scavenger included within the formulation may be dissolved, suspended and/or bonded to a polymer of the hydrogel.

公开(公告)号：US12122853B2

公开(公告)日：2024-10-22

申请号：US17687029

申请日：2022-03-04

申请人： The United States Government As Represented By The Department of Veterans Affairs

发明人： Mark B. Zimering

IPC分类号： C07K7/08 ,  A61K31/445 ,  A61K31/517 ,  A61K38/10 ,  A61P3/10

CPC分类号： C07K7/08 ,  A61K31/445 ,  A61K31/517 ,  A61K38/10 ,  A61P3/10

摘要： Disclosed herein, are decoy peptides or polypeptides capable of inhibiting binding of 5-HT2A autoantibodies to a second extracellular loop region of the 5-HT2A receptor, and a pharmaceutical composition containing the decoy peptides or polypeptides and methods of use.

公开(公告)号：US20240344027A1

公开(公告)日：2024-10-17

申请号：US18587729

申请日：2024-02-26

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Everett Hurteau Meyer ,  Robert S. Negrin

IPC分类号： C12N5/0789 ,  A61K31/436 ,  A61K31/445 ,  A61K35/12 ,  A61K35/17 ,  A61K35/28 ,  A61K39/00 ,  A61P35/02 ,  A61P37/06 ,  C12N5/0783

CPC分类号： C12N5/0647 ,  A61K31/436 ,  A61K31/445 ,  A61K35/17 ,  A61K35/28 ,  A61K39/001 ,  A61P35/02 ,  A61P37/06 ,  C12N5/0637 ,  A61K2035/122 ,  C12N2506/11

摘要： The disclosure provides methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. The disclosure provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the conventional T cells are administered after the hematopoietic stem and progenitor cells and regulatory T cells. The disclosure also provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the regulatory T cells have not been cryopreserved prior to administration.

公开(公告)号：US20240310388A1

公开(公告)日：2024-09-19

申请号：US18608576

申请日：2024-03-18

申请人： AMGEN INC.

发明人： HUIBIN YUE

IPC分类号： G01N33/68 ,  A61K31/445

CPC分类号： G01N33/6893 ,  A61K31/445 ,  G01N2333/521 ,  G01N2333/525 ,  G01N2333/5421 ,  G01N2800/20 ,  G01N2800/52 ,  G01N2800/56

摘要： The present disclosure provides diagnostic methods, that may be combined with medical treatment, using one or more plasma biomarkers that are useful for identifying a subject with Hidradenitis Suppurativa (HS), measuring disease severity of HS, and measuring clinical response in subjects with HS.

公开(公告)号：US12083118B2

公开(公告)日：2024-09-10

申请号：US16982842

申请日：2019-03-29

申请人： Arbutus Biopharma Corporation

发明人： Yingzhi Bi ,  Bruce D. Dorsey ,  Yi Fan ,  Christopher Brooks Moore ,  Duyan Nguyen

IPC分类号： A61K31/506 ,  A61K31/137 ,  A61K31/277 ,  A61K31/4164 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/505 ,  A61K45/06 ,  C07C217/58 ,  C07C255/61 ,  C07D211/60 ,  C07D233/26 ,  C07D239/06 ,  C07D401/12 ,  C07D401/14

CPC分类号： A61K31/506 ,  A61K31/137 ,  A61K31/277 ,  A61K31/4164 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/505 ,  A61K45/06 ,  C07C217/58 ,  C07C255/61 ,  C07D211/60 ,  C07D233/26 ,  C07D239/06 ,  C07D401/12 ,  C07D401/14

摘要： The present invention includes substituted 3,3′bis(phenoxymethyl)-1,1′-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.

公开(公告)号：US20240293427A1

公开(公告)日：2024-09-05

申请号：US18654262

申请日：2024-05-03

申请人： G2GBIO, INC.

发明人： Geonho KIM ,  Jinwoo LEE ,  Hyejung JUNG ,  Jaemook CHOI ,  Jeongsu BYUN ,  Juhan LEE ,  Eunyoung SEOL ,  Heeyong LEE

IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K9/16 ,  A61K31/27 ,  A61K31/407 ,  A61K31/445 ,  A61K31/522 ,  A61K31/5415 ,  A61K31/56 ,  A61K38/08 ,  A61K38/09 ,  A61K38/26 ,  A61P29/00

CPC分类号： A61K31/573 ,  A61K9/0019 ,  A61K9/1647 ,  A61K31/27 ,  A61K31/407 ,  A61K31/445 ,  A61K31/522 ,  A61K31/5415 ,  A61K31/56 ,  A61K38/08 ,  A61K38/09 ,  A61K38/26 ,  A61P29/00

摘要： The present invention is a pharmaceutical kit for combined parenteral administration, comprising a first formulation containing a first drug, and a second formulation containing a second drug and a parenteral drug delivery system, and it can be used for preventing, reducing or treating an inflammatory reaction of a subject caused by the parenteral drug delivery system of the second formulation, controlling decomposition of the parenteral drug delivery system contained in the second formulation, or increasing bioavailability of the second drug contained in the second formulation.

公开(公告)号：US12070453B2

公开(公告)日：2024-08-27

申请号：US16318905

申请日：2017-07-19

申请人： Amicus Therapeutics, Inc.

发明人： Jeff Castelli

IPC分类号： A61K31/445 ,  A61K31/45 ,  A61K31/7008

CPC分类号： A61K31/445 ,  A61K31/45 ,  A61K31/7008

摘要： Provided are dosing regimens for the treatment of Fabry disease in a patient. Certain methods relate to the treatment of ERT-experienced or ERT-nave Fabry patients. Certain methods comprise administering to the patient about 123 mg free base equivalent of migalastat for improving left ventricular mass and/or improving podocyte globotriaosylceramide.

公开(公告)号：US20240261258A1

公开(公告)日：2024-08-08

申请号：US18561529

申请日：2022-05-17

申请人： Sorrento Therapeutics, Inc.

发明人： Alexis Nahama ,  Alvaro Cisternas

IPC分类号： A61K31/357 ,  A61K31/445 ,  A61P29/00 ,  A61P41/00

CPC分类号： A61K31/357 ,  A61K31/445 ,  A61P29/00 ,  A61P41/00

摘要： Disclosed herein are methods, and compositions for use in such methods, of presurgical administering of resiniferatoxin (RTX) perineurally to provide peri-surgical and post-surgical benefits, including but not limited to decreasing post-surgical pain.

公开(公告)号：US20240252520A1

公开(公告)日：2024-08-01

申请号：US18408546

申请日：2024-01-09

申请人： Beth Israel Deaconess Medical Center, Inc. ,  President and Fellows of Harvard College

发明人： Aristidis Veves ,  George Theocharidis ,  Zhuqing Li ,  Ioannis Vlachos ,  David J. Mooney ,  Sangmin Lee

IPC分类号： A61K31/662 ,  A61K9/06 ,  A61K9/70 ,  A61K31/27 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K47/02 ,  A61K47/36 ,  A61L26/00 ,  A61P17/02

CPC分类号： A61K31/662 ,  A61K9/06 ,  A61K9/7023 ,  A61K31/27 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K47/02 ,  A61K47/36 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/008 ,  A61P17/02 ,  A61L2300/102 ,  A61L2300/216 ,  A61L2300/258 ,  A61L2300/622

摘要： In certain aspects, the disclosure relates to devices and methods for treating wounds wherein an acetylcholinesterase inhibitor is delivered to a wound to promote wound healing. In further aspects, metrifonate can be delivered to the wound by time release from a wound dressing. In further aspects a sequence of wound dressings can be applied to the wound to treat different phases of wound healing.