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公开(公告)号:US20230127906A1
公开(公告)日:2023-04-27
申请号:US18066181
申请日:2022-12-14
发明人: Brian KENNEDY , Gordon J. LITHGOW , Thomas WELDON , Daniel EDGAR , Mark LUCANIC
IPC分类号: A61K31/07 , A23K20/126 , A23K20/137 , A23K20/174 , A23L33/155 , A61K8/49 , A61K8/67 , A61K31/194 , A61K31/37 , A61K31/473 , A61Q5/10 , A61Q7/00
摘要: Described herein are compositions for delaying onset or delaying progression of frailty, reversing aging phenotype, extending healthspan, compressing morbidity, increasing lifespan and reducing formation of senescent cells.
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公开(公告)号:US11596664B2
公开(公告)日:2023-03-07
申请号:US14656084
申请日:2015-03-12
发明人: Björn Feistel , Bernd Walbroel
IPC分类号: A61K36/53 , A23L33/105 , A61K31/13 , A61K31/27 , A61K31/4015 , A61K31/445 , A61K31/473 , A61K31/48 , A61K31/4985 , A61K31/55 , A61K45/06
摘要: The invention relates to aboveground plant parts of Sideritis ssp. or extracts produced therefrom for use to boost cognitive performance.
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公开(公告)号:US11571416B2
公开(公告)日:2023-02-07
申请号:US16603907
申请日:2018-04-13
申请人: KAGOSHIMA UNIVERSITY
IPC分类号: A61K31/4706 , A61P31/14 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/5377 , A61K31/541
摘要: Described herein are pharmaceutical compositions capable of blocking entry of a virus into a host cell and containing one or more compounds of the general formula I or a pharmaceutically acceptable derivative thereof and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat viral infections.
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公开(公告)号:US11529362B2
公开(公告)日:2022-12-20
申请号:US16817683
申请日:2020-03-13
IPC分类号: A61K31/675 , A61K31/496 , A61K9/08 , A61K9/00 , A61K9/19 , A61K47/02 , A61K47/18 , A61K47/26 , A61K31/473 , A61P1/08
摘要: Injectable dosages and formulations of fosnetupitant and pharmaceutically acceptable salts thereof are provided that are efficacious, chemically stable and physiologically balanced for safety and efficacy.
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公开(公告)号:US11504379B2
公开(公告)日:2022-11-22
申请号:US16636746
申请日:2018-08-06
IPC分类号: C07C275/36 , C07C275/28 , C07C275/38 , C07C233/46 , C07C233/63 , C07C233/51 , C07C233/87 , C07C271/22 , C07C235/40 , C07D209/88 , C07D209/82 , C07D215/02 , C07D295/195 , C07D233/24 , C07D265/38 , A61P3/04 , A61P29/00 , A61P35/00 , A61K45/06 , A61K31/216 , A61K31/473 , A61K31/198 , A61K31/538 , A61K31/404
摘要: The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.
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公开(公告)号:US11471453B2
公开(公告)日:2022-10-18
申请号:US16834323
申请日:2020-03-30
发明人: Asya Rolls , Tamar Ben Shannan , Hilla Azulay-Debbie , Fahed Hakim , Maya Schiller , Shai Shen-Orr , Elina Starosvetsky
IPC分类号: A61N2/00 , A61N2/02 , A61K31/48 , A61K31/428 , A61K31/473 , A61K31/506 , A61K31/404 , A61K31/4045
摘要: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.
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公开(公告)号:US20220305015A1
公开(公告)日:2022-09-29
申请号:US17617923
申请日:2020-06-10
发明人: Mien-Chie HUNG , Mei-Kuang CHEN , Yu-Yi CHU
IPC分类号: A61K31/5025 , A61P35/00 , A61K31/502 , A61K31/4184 , A61K31/166 , A61K31/55 , A61K31/5517 , A61K31/5377 , A61K31/473 , A61K31/454 , A61K31/519 , A61K31/496 , A61K31/53 , A61K31/4439 , A61K31/498 , A61K31/4545 , A61K31/506 , A61K45/06 , C07K16/40
摘要: Provided herein are methods for identifying and treating cancers that are resistant to PARP inhibition. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided. In some aspects, PARP inhibitor cancers are treated with a PARP inhibitor therapy in combination with a receptor tyrosine kinase inhibitor.
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公开(公告)号:US20220304957A1
公开(公告)日:2022-09-29
申请号:US17421980
申请日:2020-01-13
申请人: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , University of New Orleans
发明人: Krzysztof Reiss , Branko Jursic
IPC分类号: A61K31/165 , A61P35/00 , A61K31/495 , A61K31/5377 , A61K31/4965 , A61K31/47 , A61K31/473 , A61K31/426
摘要: This invention is directed to anticancer compounds, pharmaceutical compositions comprising the same, methods of making anticancer compounds, and methods of treating cancer with compounds and pharmaceutical compositions.
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公开(公告)号:US20220249477A1
公开(公告)日:2022-08-11
申请号:US17545217
申请日:2021-12-08
IPC分类号: A61K31/506 , A61K31/167 , A61K31/19 , A61K31/27 , A61K31/4045 , A61K31/513 , A61K45/06 , A61K31/52 , A61K38/12 , A61K31/18 , A61K9/00 , A61K31/165 , A61K31/473 , A61K31/522 , A61K31/4402 , A61K38/15
摘要: Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
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公开(公告)号:US11408900B2
公开(公告)日:2022-08-09
申请号:US16070053
申请日:2017-01-13
发明人: Benjamin S. Bleier , Angela Nocera
IPC分类号: G01N33/53 , G01N33/68 , A61K9/00 , A61K45/06 , A61K31/277 , A61K31/4725 , A61K31/496 , A61K31/4164 , A61K31/4545 , A61K31/473 , A61K31/55 , A61K38/13 , A61K38/00
摘要: Methods for identifying and optionally treating subjects, e.g., subjects who have Chronic Rhinosinusitis (CRS), based on the detection of elevated levels of soluble P-glycoprotein in nasal secretions. The methods of treatment can include administration of a therapeutically effective amount of a P-glycoprotein inhibitor.
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