公开(公告)号：US11564899B2

公开(公告)日：2023-01-31

申请号：US17005893

申请日：2020-08-28

申请人： SOM INNOVATION BIOTECH, S.L.

发明人： Marc Centellas Casado ,  Raúl Insa Boronat ,  Nuria Reig Bolaño ,  Núria Gavaldà Batalla

IPC分类号： A61K31/165 ,  A61K9/16 ,  A61K31/198 ,  A61K45/06 ,  A61K31/12 ,  A61K31/353 ,  A61K31/603 ,  A61K31/423 ,  A61K31/192

摘要： It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

公开(公告)号：US20210069139A1

公开(公告)日：2021-03-11

申请号：US17013043

申请日：2020-09-04

申请人： Corino Therapeutics, Inc.

发明人： Paul Glidden ,  Michael Roberts

IPC分类号： A61K31/198 ,  A61K45/06 ,  A61K31/12 ,  A61K31/353 ,  A61K31/603 ,  A61K31/423 ,  A61K31/192

摘要： Methods of stabilizing transthyretin (TTR) tetramers in the biological fluids of human patients comprising administering a catechol-O-methyltransferase (COMT) inhibitor are provided. Also provided are methods of treating human patients with TTR-associated amyloidosis comprising administering a COMT inhibitor the crosses the blood brain barrier and stabilizes TTR in the cerebrospinal fluid (CSF) of a patient.

公开(公告)号：US20200009119A1

公开(公告)日：2020-01-09

申请号：US16573384

申请日：2019-09-17

申请人： SEN-JAM PHARMACEUTICAL LLC

发明人： Jacqueline M. Iversen ,  James M. Iversen

IPC分类号： A61K31/445 ,  A61K31/192 ,  A61K9/00 ,  A61K31/196 ,  A61K31/407 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/60 ,  A61K31/603 ,  A61K45/06

摘要： The present invention relates to a method of reducing or preventing the symptoms associated with the intake of alcohol. The method comprises administering to a subject an effective amount of a pharmaceutical composition prior to alcohol intake. The pharmaceutical composition comprises a non-steroidal anti-inflammatory drug and a H1-antihistamine.

公开(公告)号：US20190224211A1

公开(公告)日：2019-07-25

申请号：US15997020

申请日：2018-06-04

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Nicholas E. GOEDERS ,  Christopher Dalton SCHMOUTZ

IPC分类号： A61K31/5513 ,  A61K45/06 ,  A61K31/568 ,  A61K31/5517 ,  A61K31/501 ,  A61K31/603

摘要： A method of treating a condition of in a human patient comprising pharmacologically activating a translocator protein of 18 kDa (TSPO), wherein the condition is one of a chronic methamphetamine addiction, a medical consequence of methamphetamine use; a behavioral consequence of methamphetamine use, an HIV associated cognitive motor disorder, an HIV-associated neurodegenerative disorder, and a neuroinflammatory response.

公开(公告)号：US20190183837A1

公开(公告)日：2019-06-20

申请号：US16284461

申请日：2019-02-25

申请人： Biosuccess Biotech Co., Ltd.

发明人： Hung-Fong CHEN ,  Zheng Tao HAN

IPC分类号： A61K31/225 ,  A61K31/55 ,  A61K31/381 ,  A61K31/216 ,  A61K31/573 ,  A61K31/22 ,  A61K45/06 ,  A61K31/603

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.

公开(公告)号：US20190091188A1

公开(公告)日：2019-03-28

申请号：US16101882

申请日：2018-08-13

申请人： SOM INNOVATION BIOTECH, S.L.

发明人： Marc Centellas Casado ,  Raúl Insa Boronat ,  Núria Reig Bolano ,  Nuria Gavaldà Batalla

IPC分类号： A61K31/198 ,  A61K31/192 ,  A61K31/423 ,  A61K45/06 ,  A61K31/603 ,  A61K31/12 ,  A61K31/353

摘要： It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

公开(公告)号：US09750713B2

公开(公告)日：2017-09-05

申请号：US15154100

申请日：2016-05-13

申请人： Biosuccess Biotech Co. Ltd.

发明人： Hung-Fong Chen ,  Zheng Tao Han

IPC分类号： A61K31/23 ,  A61K31/21 ,  A61K31/235 ,  A61K31/225 ,  A61K45/06 ,  A61K31/573 ,  A61K31/603 ,  A61K31/22 ,  A61K31/216 ,  A61K31/381 ,  A61K31/55

CPC分类号： A61K31/225 ,  A61K31/216 ,  A61K31/22 ,  A61K31/381 ,  A61K31/55 ,  A61K31/573 ,  A61K31/603 ,  A61K45/06 ,  A61K2300/00

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.

公开(公告)号：US09675664B2

公开(公告)日：2017-06-13

申请号：US14676132

申请日：2015-04-01

申请人： Women & Infants' Hospital of Rhode Island

发明人： Surendra Sharma ,  Satyan Kalkunte ,  Udo Markert

IPC分类号： A61K38/16 ,  A61K38/00 ,  A61K38/17 ,  A61K31/196 ,  A61K31/60 ,  A61K31/603 ,  A61K31/616 ,  A61K38/38 ,  A61K45/06 ,  C07K14/47 ,  G01N33/78

CPC分类号： A61K38/1709 ,  A61K31/196 ,  A61K31/60 ,  A61K31/603 ,  A61K31/616 ,  A61K38/38 ,  A61K45/06 ,  C07K14/47 ,  G01N33/78 ,  A61K2300/00

摘要： This invention discloses a method of and composition for treating a PE-type disorder in a subject in need of such treatment comprising administering to the subject a pharmaceutical composition containing a therapeutically effective amount of a TTR polypeptide in admixture with a pharmaceutically acceptable vehicle.

公开(公告)号：US09610270B2

公开(公告)日：2017-04-04

申请号：US14353459

申请日：2012-10-23

申请人： SOM INNOVATION BIOTECH, S.L.

发明人： Marc Centellas Casado ,  Raúl Insa Boronat ,  Nuria Reig Bolaño ,  Núria Gavaldà Batalla

IPC分类号： A61K31/42 ,  A61K31/165 ,  A61K31/12 ,  A61K31/198 ,  A61K45/06 ,  A61K31/353 ,  A61K31/423 ,  A61K31/603 ,  A61K31/192

CPC分类号： A61K31/198 ,  A61K31/12 ,  A61K31/192 ,  A61K31/353 ,  A61K31/423 ,  A61K31/603 ,  A61K45/06 ,  A61K2300/00

摘要： It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

公开(公告)号：US20160287613A1

公开(公告)日：2016-10-06

申请号：US15034938

申请日：2014-10-30

申请人： Werner KREUTZ

发明人： Werner KREUTZ

IPC分类号： A61K31/616 ,  A61K31/603 ,  A61K31/606

CPC分类号： A61K31/616 ,  A61K31/603 ,  A61K31/606 ,  A61K2300/00

摘要： The present invention relates to salicylates for use in the cancer.

摘要翻译： 本发明涉及用于癌症的水杨酸盐。