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1878 条记录 (耗时 0.032 秒)

    SYSTEMS AND METHODS FOR DELIVERY OF HUMANIN OR OTHER PEPTIDES
    7.
    发明公开
    SYSTEMS AND METHODS FOR DELIVERY OF HUMANIN OR OTHER PEPTIDES 审中-公开

    公开(公告)号：US20240156900A1

    公开(公告)日：2024-05-16

    申请号：US17975950

    申请日：2022-10-28

    申请人： Transdermal Biotechnology, Inc.

    发明人： Nicholas V. Perricone

    IPC分类号： A61K38/17 ,  A61K9/00 ,  A61K31/685 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24

    CPC分类号： A61K38/1709 ,  A61K9/0014 ,  A61K31/685 ,  A61K47/14 ,  A61K47/183 ,  A61K47/24

    摘要： The present disclosure generally relates to systems and methods for delivering humanin and/or other peptides to a subject. In some cases, these may be used for treating or preventing aging skin, or for other diseases. Non-limiting examples of other peptides include mitochondrial-derived peptides such as HNG or MOTS-c. In addition, certain embodiments are generally directed to treatments that can be delivered using topical compositions applied to the skin. For example, in some cases, the composition includes lecithin and/or other components that may facilitate delivery through the skin. Further, certain embodiments may include active ingredients such as tributyrin or 2,6-dimethyl-L-tyrosine, which may interact with humanin or other peptides. Compositions such as these may be used in certain embodiments, for example, to reduce inflammation within the skin, or as an anti-aging treatment, etc. Other aspects are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

    TREATMENT OF CYTOKINE RELEASE SYNDROME WITH GM-CSF ANTAGONISTS
    8.
    发明公开
    TREATMENT OF CYTOKINE RELEASE SYNDROME WITH GM-CSF ANTAGONISTS 审中-公开

    公开(公告)号：US20240117058A1

    公开(公告)日：2024-04-11

    申请号：US18485116

    申请日：2023-10-11

    申请人： Kiniksa Pharmaceuticals, Ltd.

    发明人： Joe Pirrello ,  John Paolini ,  Eben Tessari

    IPC分类号： C07K16/28 ,  A61K31/573 ,  A61K31/685 ,  A61P31/14

    CPC分类号： C07K16/2866 ,  A61K31/573 ,  A61K31/685 ,  A61P31/14 ,  A61K2039/545

    摘要： The present invention provides, among other things, a method of treating a subject with infection-induced hyperinflammation comprising administering to the subject a granulocyte-macrophage colony-stimulating factor (GM-CSF) antagonist at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce one or more symptoms of hyperinflammation. The present invention also provides, among other things, a method of inhibiting or reducing cytokine release syndrome (CRS) or acute respiratory distress syndrome (ARDS) in a subject comprising administering to the subject a granulocyte-macrophage colony-stimulating factor (GM-CSF) antagonist at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce one or more symptoms of CRS or ARDS.