公开(公告)号：US20250025615A1

公开(公告)日：2025-01-23

申请号：US18716071

申请日：2022-11-29

Applicant: GAMBRO LUNDIA AB

Inventor： Sture HOBRO ,  Anders NILSSON

IPC: A61M1/28 ,  A61K31/198 ,  A61K31/22 ,  A61K31/7004 ,  A61K47/10 ,  A61K47/42 ,  A61P35/00

Abstract: The present application provides a dialysis fluid comprising ketone bodies such as acetoacetate, beta-hydroxybutyrate or pharmaceutically acceptable derivatives, esters and salts thereof, for use in a peritoneal dialysis therapy method of treating cancer.

公开(公告)号：US20240374534A1

公开(公告)日：2024-11-14

申请号：US18672929

申请日：2024-05-23

Applicant: University of Miami

Inventor： Shaun BROTHERS ,  Claes WAHLESTEDT ,  Claude Henry VOLMAR

IPC: A61K31/05 ,  A61K9/00 ,  A61K31/03 ,  A61K31/09 ,  A61K31/166 ,  A61K31/185 ,  A61K31/194 ,  A61K31/235 ,  A61K31/36 ,  A61K31/423 ,  A61K31/69 ,  A61K31/7004 ,  A61K45/06 ,  A61P3/00

Abstract: The present invention provides methods and compositions for the treatment of mucopolysaccharidoses (MPS).

公开(公告)号：US20240360454A1

公开(公告)日：2024-10-31

申请号：US18623281

申请日：2024-04-01

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Simina Ticau ,  Anna Borodovsky

IPC: C12N15/113 ,  A61K31/555 ,  A61K31/7004 ,  A61P1/16 ,  G01N33/68

CPC classification number: C12N15/1137 ,  A61K31/555 ,  A61K31/7004 ,  A61P1/16 ,  G01N33/6893 ,  C12N2310/11 ,  C12N2310/14 ,  G01N2800/08 ,  G01N2800/60

Abstract: The disclosure provides biomarkers for diagnosis and monitoring of acute hepatic porphyria (AHP). The disclosure further provides methods for selection of agents for treatment of AHP using the biomarkers. The disclosure further provides kits for practicing the methods provided herein.

公开(公告)号：US20240325421A1

公开(公告)日：2024-10-03

申请号：US18740196

申请日：2024-06-11

Applicant: NISIBIS, LLC-S

Inventor： Ronald MICHAEL ,  Fredrick N. MICHAEL

IPC: A61K31/7048 ,  A61K31/404 ,  A61K31/409 ,  A61K31/655 ,  A61K31/661 ,  A61K31/7004 ,  A61K31/702 ,  A61K31/714 ,  A61K45/06

CPC classification number: A61K31/7048 ,  A61K31/404 ,  A61K31/409 ,  A61K31/655 ,  A61K31/661 ,  A61K31/7004 ,  A61K31/702 ,  A61K31/714 ,  A61K45/06

Abstract: The present disclosure relates to pharmaceutical compositions comprising PTEN inhibitors and methods of treating or preventing bone marrow loss in subjects in subjects in need thereof. The compositions and methods of this disclosure are useful in treating or preventing bone marrow loss associated with exposure to nuclear radiation or chemotherapeutic treatment.

公开(公告)号：US20240316012A1

公开(公告)日：2024-09-26

申请号：US18614107

申请日：2024-03-22

Applicant: Northwestern University ,  Technische Universität München

Inventor： Jaehyuk Choi ,  Jay Carroll Daniels ,  Jurgen Ruland ,  Tim Wartewig

IPC: A61K31/436 ,  A61K31/18 ,  A61K31/7004 ,  A61P35/00

CPC classification number: A61K31/436 ,  A61K31/18 ,  A61K31/7004 ,  A61P35/00

Abstract: Provided herein is a method for treating a lymphoma in a subject in need thereof, comprising administering to the subject an effective amount of at least one PD-1 pathway agonist.

公开(公告)号：US20240299429A1

公开(公告)日：2024-09-12

申请号：US18565787

申请日：2023-08-02

Applicant: SUNUS CO., LTD.

Inventor： Kazuhiro YOSHINAGA

IPC: A61K31/7004

CPC classification number: A61K31/7004

Abstract: There is provided a preventive and therapeutic agent for urinary tract infection containing 1-deoxymannose.

公开(公告)号：US20240293473A1

公开(公告)日：2024-09-05

申请号：US18424075

申请日：2024-01-26

Applicant: Viktor Veniaminovich TETS ,  Georgy Viktorovich TETS

Inventor： Viktor Veniaminovich TETS ,  Georgy Viktorovich TETS

IPC: A61K35/74 ,  A61K31/65 ,  A61K31/7004 ,  A61K33/06 ,  A61K35/745 ,  A61K35/747 ,  A61K35/76 ,  A61K38/08 ,  A61K38/17 ,  A61K38/46 ,  A61K39/00 ,  A61K39/108 ,  A61P3/10 ,  C07K16/12 ,  C12N15/113 ,  C12Q1/6883

CPC classification number: A61K35/74 ,  A61K31/65 ,  A61K31/7004 ,  A61K33/06 ,  A61K35/745 ,  A61K35/747 ,  A61K35/76 ,  A61K38/08 ,  A61K38/1709 ,  A61K38/465 ,  A61K39/0258 ,  A61P3/10 ,  C07K16/1232 ,  C12N15/113 ,  C12Q1/6883 ,  A61K2039/505 ,  C12N2310/14 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Methods for preventing, treating or diagnosing Type 1 Diabetes (T1D) are described. Amyloid-producing bacteria within microbiota are inactivated. Amyloid-producing bacteria are inactivated in microbiota, gastrointestinal tract, bodily fluids or tissues. Type-1 Diabetes associated microbial product production or release by microbiota is prevented. Also described is inactivation of bacteria-derived T1DAMP present in microbiota, bodily fluids or tissues of a mammal. Release of bacteria-derived T1DAMP from biofilm or bacteria to gastrointestinal tract is inhibited. Entry of bacteria-derived T1DAMP to microbiota, gastrointestinal tract, bodily fluids or tissues of a mammal is inhibited.

公开(公告)号：US12048694B2

公开(公告)日：2024-07-30

申请号：US17315136

申请日：2021-05-07

Applicant: St. Jude Children's Research Hospital

Inventor： Heather Smallwood ,  Marie Morfouace ,  Martine F. Roussel ,  Paul G. Thomas

IPC: A61K31/4745 ,  A61K31/277 ,  A61K31/34 ,  A61K31/352 ,  A61K31/365 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/505 ,  A61K31/519 ,  A61K31/555 ,  A61K31/7004 ,  A61K45/06

CPC classification number: A61K31/4745 ,  A61K31/277 ,  A61K31/34 ,  A61K31/352 ,  A61K31/365 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/505 ,  A61K31/519 ,  A61K31/555 ,  A61K31/7004 ,  A61K45/06 ,  A61K31/519 ,  A61K2300/00 ,  A61K31/454 ,  A61K2300/00 ,  A61K31/433 ,  A61K2300/00 ,  A61K31/415 ,  A61K2300/00 ,  A61K31/34 ,  A61K2300/00 ,  A61K31/4164 ,  A61K2300/00 ,  A61K31/505 ,  A61K2300/00 ,  A61K31/427 ,  A61K2300/00 ,  A61K31/4745 ,  A61K2300/00

Abstract: The invention generally relates to methods of treating viral infections using known drugs and pharmaceutical compositions comprising same. More specifically, the disclosed methods are useful for the treatment of viral infections that are enveloped viruses. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11998565B2

公开(公告)日：2024-06-04

申请号：US18124391

申请日：2023-03-21

Applicant: AMERICAN REGENT, INC.

Inventor： Gopal Anyarambhatla ,  Richard Lawrence ,  Jasmina Marinkovic

IPC: A61K33/30 ,  A61K9/00 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/22 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34 ,  A61K47/10 ,  A61K47/20 ,  A61P3/02

CPC classification number: A61K33/30 ,  A61K9/0029 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/22 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34 ,  A61K47/10 ,  A61K47/20 ,  A61P3/02

Abstract: Injectable compositions that can be added to parenteral nutrition are provided. In particular, a stable injectable composition is provided which includes water, and at least one of about 800 μg to about 4,000 μg of zinc, about 40 μg to about 400 μg of copper, from about 4 μg to about 90 μg of selenium, or from about 1 μg to about 80 μg of manganese per 1 mL of the injectable composition. Methods of preparing and using of the stable injectable composition are also provided.

公开(公告)号：US11975022B2

公开(公告)日：2024-05-07

申请号：US18482612

申请日：2023-10-06

Applicant: American Regent, Inc.

Inventor： Gopal Anyarambhatla ,  Richard Lawrence ,  Jasmina Marinkovic

IPC: A61K33/30 ,  A61K9/00 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/22 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34 ,  A61K47/10 ,  A61K47/20 ,  A61P3/02

CPC classification number: A61K33/30 ,  A61K9/0029 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/22 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34 ,  A61K47/10 ,  A61K47/20 ,  A61P3/02

Abstract: Injectable compositions that can be added to parenteral nutrition are provided. In particular, a stable injectable composition is provided which includes water, and at least one of about 800 μg to about 4,000 μg of zinc, about 40 μg to about 400 μg of copper, from about 4 μg to about 90 μg of selenium, or from about 1 μg to about 80 μg of manganese per 1 mL of the injectable composition. Methods of preparing and using of the stable injectable composition are also provided.