公开(公告)号：US20240342203A1

公开(公告)日：2024-10-17

申请号：US18750831

申请日：2024-06-21

申请人： GR BIOSYSTEMS, INC.

发明人： Andrew J. GROSS ,  Shane RIRIE

IPC分类号： A61K31/7034 ,  A61K9/00 ,  A61K31/12 ,  A61K31/121 ,  A61K31/16 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/34 ,  A61P35/00

CPC分类号： A61K31/7034 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0063 ,  A61K31/12 ,  A61K31/121 ,  A61K31/16 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/34 ,  A61P35/00

摘要： The present disclosure generally relates to compositions that inhibit matrix metalloproteinases (MMPs). These compositions may be particularly useful in treating oral cancer or an oropharyngeal cancer. The compositions can be prepared as a topical formulation, ointment, mouthwash, or packaged in a syringe.

公开(公告)号：US20240325356A1

公开(公告)日：2024-10-03

申请号：US18741528

申请日：2024-06-12

申请人： Kowa Company, Ltd

发明人： Yusuke Sasaki ,  Masato Asahiyama ,  Toshiya Tanaka

IPC分类号： A61K31/423 ,  A61K31/7034 ,  A61K31/7048 ,  A61P1/16

CPC分类号： A61K31/423 ,  A61P1/16 ,  A61K31/7034 ,  A61K31/7048

摘要： The present invention addresses the problem of providing a medicinal composition and a drug combination by which nonalcoholic fatty liver disease and nonalcoholic steatohepatitis can be prevented and/or treated. The present invention provides a combination of a peroxisome proliferator-activated receptor (PPAR) a agonist with a sodium glucose cotransporter 2 (SGLT2) inhibitor, which is to be used for preventing and/or treating nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

公开(公告)号：US20240226125A1

公开(公告)日：2024-07-11

申请号：US18613381

申请日：2024-03-22

申请人： LEXICON PHARMACEUTICALS, INC.

发明人： Phillip BANKS ,  Sangeeta SAWHNEY

IPC分类号： A61K31/7034 ,  A61K9/00

CPC分类号： A61K31/7034 ,  A61K9/0053

摘要： The invention relates to the use of sotagliflozin to improve glycemic control in adults with type 1 diabetes mellitus with a Body Mass Index (BMI) ≥27 kg/m2.

公开(公告)号：US20240207179A1

公开(公告)日：2024-06-27

申请号：US18364273

申请日：2023-08-02

申请人： Trait Biosciences Inc.

发明人： Richard T. Sayre ,  Elton Carvalho Gonçalves ,  Tawanda Zidenga ,  Stephanie Willette

IPC分类号： A61K9/00 ,  A23L33/105 ,  A23L33/125 ,  A61K9/08 ,  A61K31/7034 ,  A61K47/26 ,  A61K47/36 ,  C12G3/04

CPC分类号： A61K9/0095 ,  A23L33/105 ,  A23L33/125 ,  A61K9/08 ,  A61K31/7034 ,  A61K47/26 ,  A61K47/36 ,  C12G3/04 ,  A23V2002/00

摘要： The present invention includes systems, methods and compositions related to the production and use of chemically modified cannabinoid food and beverage additives having enhanced water solubility and stability.

公开(公告)号：US12016871B2

公开(公告)日：2024-06-25

申请号：US17249976

申请日：2021-03-19

申请人： GR BIOSYSTEMS, INC.

发明人： Andrew J. Gross ,  Shane Ririe

IPC分类号： A61K31/7034 ,  A61K9/00 ,  A61K31/12 ,  A61K31/121 ,  A61K31/16 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/34 ,  A61P35/00

CPC分类号： A61K31/7034 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0063 ,  A61K31/12 ,  A61K31/121 ,  A61K31/16 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/34 ,  A61P35/00

摘要： The present disclosure generally relates to compositions that inhibit matrix metalloproteinases (MMPs). These compositions may be particularly useful in treating oral cancer or an oropharyngeal cancer. The compositions can be prepared as a topical formulation, ointment, mouthwash, or packaged in a syringe.

公开(公告)号：US12016832B2

公开(公告)日：2024-06-25

申请号：US17571731

申请日：2022-01-10

申请人： Clexio Biosciences Ltd.

发明人： Elena Kagan ,  Gina Pastino

IPC分类号： A61K31/135 ,  A61K9/00 ,  A61K9/16 ,  A61K31/136 ,  A61K31/15 ,  A61K31/343 ,  A61K31/36 ,  A61K31/381 ,  A61K31/7034 ,  A61P25/24

CPC分类号： A61K31/135 ,  A61K9/0053 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/167 ,  A61K31/136 ,  A61K31/15 ,  A61K31/343 ,  A61K31/36 ,  A61K31/381 ,  A61K31/7034 ,  A61P25/24

摘要： The present invention provides a method for safe and efficacious administration of esketamine.

公开(公告)号：US20240189257A1

公开(公告)日：2024-06-13

申请号：US18282672

申请日：2021-03-25

申请人： SAMI-SABINSA GROUP LIMITED

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sarang Bani ,  Anjali Pandey

IPC分类号： A61K31/12 ,  A61K31/37 ,  A61K31/7034 ,  A61K36/185 ,  A61K36/48 ,  A61P13/12

CPC分类号： A61K31/12 ,  A61K31/37 ,  A61K31/7034 ,  A61K36/185 ,  A61K36/48 ,  A61P13/12

摘要： The invention discloses the use of a composition comprising 70%-80% w/w tetrahydrocurcuminoids, 10%-20% w/w hexahydrocurcuminoids and 5%-10% w/w octahydrocurcuminoids in the therapeutic management of nephropathy in mammals. The composition further comprises β-glucogallin and total mucic acid gallates, C-glucosides and tannins isolated from Pterocarpus marsupium. The invention also discloses the potential of the composition comprising β-glucogallin and total mucic acid gallates from Emblica officinalis, C-glucosides and tannins isolated from Pterocarpus marsupium in the therapeutic management of nephropathy.

公开(公告)号：US11987598B2

公开(公告)日：2024-05-21

申请号：US17724585

申请日：2022-04-20

申请人： GLYCOMIMETICS, INC.

发明人： John L. Magnani ,  Arun K. Sarkar ,  Myung-Gi Baek ,  Frank E. Anderson, III ,  Yanhong Li

IPC分类号： A61K31/7034 ,  A61K45/06 ,  C07H15/207 ,  C07H15/26 ,  C09C1/62

CPC分类号： C07H15/207 ,  A61K31/7034 ,  A61K45/06 ,  C07H15/26 ,  C09C1/62

摘要： Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

公开(公告)号：US20240156848A1

公开(公告)日：2024-05-16

申请号：US18422333

申请日：2024-01-25

申请人： Boehringer Ingelheim International GmbH

发明人： Uli Christian BROEDL ,  Odd-Erik JOHANSEN ,  Gabriel Woojai KIM ,  Eric Williams MAYOUX ,  Afshin SALSALI ,  Nima SOLEYMANLOU ,  Maximilian von EYNATTEN ,  Hans-Juergen WOERLE ,  David Z.I. CHERNEY ,  Bruce A. PERKINS ,  Andreas DAIBER ,  Thomas MUENZEL

IPC分类号： A61K31/7048 ,  A61K9/20 ,  A61K9/28 ,  A61K31/155 ,  A61K31/522 ,  A61K31/7034 ,  A61K45/06

CPC分类号： A61K31/7048 ,  A61K9/2018 ,  A61K9/2866 ,  A61K31/155 ,  A61K31/522 ,  A61K31/7034 ,  A61K45/06

摘要： The present invention relates to certain SGLT-2 inhibitors for treating and/or preventing oxidative stress, for example in patients with type 1 or type 2 diabetes, as well as to the use of such SGLT-2 inhibitors in treatment and/or prevention of cardiovascular diseases in patients, for example type 1 or type 2 diabetes patients. The present invention further relates to certain SGLT-2 inhibitors for treating and/or preventing a metabolic disorder and preventing, reducing the risk of or delaying the occurrence of a cardiovascular event in patients, for example patients with type 1 or type 2 diabetes.

公开(公告)号：US11963969B2

公开(公告)日：2024-04-23

申请号：US17932781

申请日：2022-09-16

申请人： BUDDHIST TZU CHI MEDICAL FOUNDATION

发明人： Chia-Yu Chang ,  Shinn-Zong Lin ,  Hsiao-Chien Ting ,  Hui-I Yang ,  Horng-Jyh Harn ,  Hong-Lin Su ,  Ching-Ann Liu ,  Yu-Shuan Chen ,  Tzyy-Wen Chiou ,  Tsung-Jung Ho

IPC分类号： A61K31/7034 ,  A61K9/00 ,  A61K31/428 ,  A61P25/28

CPC分类号： A61K31/7034 ,  A61K9/0019 ,  A61K31/428 ,  A61P25/28

摘要： Provided is a pharmaceutical composition including gastrodin and a use thereof for the prevention or the treatment of amyotrophic lateral sclerosis. The pharmaceutical composition is effective in reducing neuronal axon degeneration and neurofibromin accumulation, improving symptoms of amyotrophic lateral sclerosis and extending life of patients of amyotrophic lateral sclerosis.