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    HYDROGEL-BASED BIOLOGICAL DELIVERY VEHICLE
    1.
    发明申请
    HYDROGEL-BASED BIOLOGICAL DELIVERY VEHICLE 有权

    公开(公告)号：US20230080761A1

    公开(公告)日：2023-03-16

    申请号：US17946849

    申请日：2022-09-16

    申请人： InSitu Biologics, Inc.

    发明人： William Taylor ,  Daniel Sipple ,  James Segermark

    IPC分类号： A61K9/00 ,  A61K47/36 ,  A61K9/06 ,  A61K31/327 ,  A61K31/738 ,  C12N9/08

    摘要： A hydrogel-based biological delivery vehicle used to effectively deliver drug and biological material to tissue or organ sites. More specifically, a hydrogel binding matrix having a biopolymer backbone containing carboxyl groups. Tyramine may be substituted for at least a portion of the carboxyl groups, so that, when hydrogen peroxide is added, it causes creation of covalent bonds between tyramine molecules and cross-links the hydrogel binding matrix, thereby enabling the hydrogel binding matrix to transition from liquid to gel state. The hydrogel binding matrix, in its liquid form, is capable of encapsulating drug reservoirs to create a homogenous liquid with evenly distributed particles containing drugs or target molecules. As the hydrogel binding matrix solidifies into a gel state, the newly created cross-links do not disrupt or react with the drugs or target molecules contained within the drug reservoirs. This hydrogel-based biological delivery vehicle can be used in several medical applications.

    Hydrogel-based biological delivery vehicle
    3.
    发明授权
    Hydrogel-based biological delivery vehicle 有权

    公开(公告)号：US11471402B2

    公开(公告)日：2022-10-18

    申请号：US16300660

    申请日：2017-05-12

    申请人： InSitu Biologics, Inc.

    发明人： William Taylor ,  Daniel Sipple ,  James Segermark

    IPC分类号： A61K9/00 ,  A61K47/36 ,  A61K9/06 ,  A61K31/327 ,  A61K31/738 ,  C12N9/08

    摘要： A hydrogel-based biological delivery vehicle used to effectively deliver drug and biological material to tissue or organ sites. More specifically, a hydrogel binding matrix having a biopolymer backbone containing carboxyl groups. Tyramine may be substituted for at least a portion of the carboxyl groups, so that, when hydrogen peroxide is added, it causes creation of covalent bonds between tyramine molecules and cross-links the hydrogel binding matrix, thereby enabling the hydrogel binding matrix to transition from liquid to gel state. The hydrogel binding matrix, in its liquid form, is capable of encapsulating drug reservoirs to create a homogenous liquid with evenly distributed particles containing drugs or target molecules. As the hydrogel binding matrix solidifies into a gel state, the newly created cross-links do not disrupt or react with the drugs or target molecules contained within the drug reservoirs. This hydrogel-based biological delivery vehicle can be used in several medical applications.

    One-step processing of hydrogels for mechanically robust and chemically desired features
    7.
    发明授权
    One-step processing of hydrogels for mechanically robust and chemically desired features 有权

    公开(公告)号：US11246937B2

    公开(公告)日：2022-02-15

    申请号：US16358948

    申请日：2019-03-20

    申请人： Board of Regents, The University of Texas System

    发明人： Sarah Mayes ,  Christine Schmidt

    IPC分类号： A61K31/738 ,  A61K47/36

    摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

    A POLYMER NETWORK, METHOD FOR PRODUCTION, AND USES THEREOF
    8.
    发明申请
    A POLYMER NETWORK, METHOD FOR PRODUCTION, AND USES THEREOF 审中-公开

    公开(公告)号：US20200030368A1

    公开(公告)日：2020-01-30

    申请号：US16321674

    申请日：2017-07-28

    申请人： JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH

    发明人： Jayanta HALDAR ,  Jiaul HOQUE

    IPC分类号： A61K31/738 ,  C08B37/08 ,  C08B37/02 ,  A61K9/06 ,  A61K33/38 ,  A61P31/04

    摘要： The present disclosure relates to a polymer network comprising a compound of Formula I cross-linked to a compound selected from the group consisting of a compound of Formula II; hyaluronate aldehyde, alginate aldehyde, dextran aldehyde, starch aldehyde, and chitosan aldehyde. It also relates to a process of preparing the polymer network. The present disclosure further relates to compositions comprising the polymer network and methods of preventing conditions and diseases that are caused by micro-organism. The present disclosure still further relates to a biocompatible antimicrobial hydrogel, a process for preparing the hydrogel, and methods of using the same, including a variety of tissue-related applications in which rapid adhesion to the tissue and gel formation is desired, as well as local delivery of pharmaceutical drugs to a site of application.