公开(公告)号：US12097223B2

公开(公告)日：2024-09-24

申请号：US17022807

申请日：2020-09-16

申请人： Astellas Institute for Regenerative Medicine

发明人： Erin Anne Kimbrel ,  Robert P. Lanza ,  Jianlin Chu ,  Nicholas Arthur Kouris

IPC分类号： C12N5/0775 ,  A61F2/14 ,  A61F9/08 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/39 ,  A61K35/407 ,  C12N5/071 ,  C12N5/0789 ,  G06F9/54

CPC分类号： A61K35/28 ,  A61F2/141 ,  A61F9/08 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/39 ,  A61K35/407 ,  C12N5/0647 ,  C12N5/0662 ,  C12N5/0668 ,  C12N5/0692 ,  G06F9/542 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/26 ,  C12N2502/1171 ,  C12N2506/02 ,  C12N2506/11 ,  C12N2506/28 ,  C12N2533/54 ,  G06F2218/00 ,  A61K35/30 ,  A61K2300/00 ,  A61K35/34 ,  A61K2300/00 ,  A61K35/36 ,  A61K2300/00 ,  A61K35/39 ,  A61K2300/00 ,  A61K35/407 ,  A61K2300/00 ,  A61K35/28 ,  A61K2300/00

摘要： The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

公开(公告)号：US12066431B2

公开(公告)日：2024-08-20

申请号：US17201036

申请日：2021-03-15

申请人： Accelerated Biosciences Corp.

发明人： Jau-Nan Lee ,  Tony Tung-Ying Lee ,  Yuta Lee

IPC分类号： G01N33/50 ,  A61K35/39 ,  A61K35/54 ,  A61K39/395 ,  C12N5/071 ,  C12N5/073 ,  C12N5/0735 ,  A61K35/12

CPC分类号： G01N33/5073 ,  A61K35/39 ,  A61K35/54 ,  A61K39/395 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0677 ,  A61K35/12 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2506/02 ,  C12N2533/54

摘要： Disclosed herein are human trophoblast stem (hTS) cells, differentiated cells thereof, derivatives thereof such as cellular mass, and uses thereof. The isolation of hTS cells can express FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. The hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In the hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. The hTS cells could apply to human cell differentiation and for gene and cell-based therapies.

公开(公告)号：US20240269194A1

公开(公告)日：2024-08-15

申请号：US18567094

申请日：2022-06-09

申请人： City of Hope

发明人： Fouad Kandeel

IPC分类号： A61K35/39 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/4985 ,  A61K38/22 ,  A61P3/10 ,  C12N5/071

CPC分类号： A61K35/39 ,  A61K9/0019 ,  A61K31/4439 ,  A61K31/4985 ,  A61K38/2207 ,  A61P3/10 ,  C12N5/0676

摘要： Provided herein, inter alia, are compositions and methods for treating diabetes in a subject in need thereof. The methods include administering to the subject gastrin-treated islet cells.

公开(公告)号：US12049646B2

公开(公告)日：2024-07-30

申请号：US18395362

申请日：2023-12-22

申请人： President and Fellows of Harvard College

发明人： Quinn P. Peterson ,  Felicia J. Pagliuca ,  Douglas A. Melton ,  Jeffrey Robert Millman ,  Michael Saris Segel ,  Mads Gurtler

IPC分类号： C12N5/071 ,  A61K35/39 ,  A61P3/10 ,  A61P5/48 ,  A61P5/50 ,  C12N5/0735 ,  C12N5/074

CPC分类号： C12N5/0678 ,  A61K35/39 ,  A61P3/10 ,  A61P5/48 ,  A61P5/50 ,  C12N5/0606 ,  C12N5/0676 ,  C12N5/0696 ,  C12N2501/11 ,  C12N2501/117 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2501/375 ,  C12N2501/385 ,  C12N2501/395 ,  C12N2501/40 ,  C12N2501/41 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2506/22 ,  C12N2506/45

摘要： Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

公开(公告)号：US20240245733A1

公开(公告)日：2024-07-25

申请号：US18435722

申请日：2024-02-07

申请人： The Regents of the University of California ,  U.S. Govenment Represented by the Department of Veterans Affairs

发明人： Casey Ward ,  Qizhi TANG ,  Peter STOCK ,  Gaetano FALEO ,  Gopika NAIR ,  Matthias HEBROK ,  Wenhan CHANG ,  Thuy VO ,  Jeffrey A. BLUESTONE ,  Elenora DE KLERK

IPC分类号： A61K35/55 ,  A61K9/00 ,  A61K35/39 ,  A61P3/10 ,  C12N5/071

CPC分类号： A61K35/55 ,  A61K9/0019 ,  A61K9/0024 ,  A61K35/39 ,  A61P3/10 ,  C12N5/0617 ,  C12N5/0676 ,  A61K2300/00 ,  C12N2506/02 ,  C12N2506/078

摘要： Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.

公开(公告)号：US20240207325A1

公开(公告)日：2024-06-27

申请号：US18554136

申请日：2022-04-08

申请人： BIOCRINE AB

发明人： Per-Olof Berggren ,  Ingo Leibiger ,  Barbara Leibiger

IPC分类号： A61K35/39 ,  A61K38/22 ,  A61K38/26 ,  A61P3/04 ,  C07K14/575 ,  C07K14/605 ,  C12N5/071 ,  C12N15/86

CPC分类号： A61K35/39 ,  A61K38/2264 ,  A61K38/26 ,  A61P3/04 ,  C07K14/5759 ,  C07K14/605 ,  C12N5/0677 ,  C12N15/86 ,  C12N2533/50 ,  C12N2710/10043

摘要： Engineered pancreatic islet organoids encoding a polypeptide not endogenously expressed in pancreatic islet cells and methods for using them to treat diseases and disorders associated with reduced or absent expression of the polypeptide are provided.

公开(公告)号：US20240189365A1

公开(公告)日：2024-06-13

申请号：US18286955

申请日：2022-04-14

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Christopher BURLAK

IPC分类号： A61K35/407 ,  A61K35/22 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/42 ,  A61K35/55 ,  A61P37/06 ,  C12N5/071

CPC分类号： A61K35/407 ,  A61K35/22 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/42 ,  A61K35/55 ,  A61P37/06 ,  C12N5/0676 ,  C12N2510/00

摘要： Provided herein are genetically modified porcine cells comprising a reduced or eliminated level of β1,3-N-acetylglucosaminyltransferase 5 (B3gnt5) activity as compared to a normal porcine cell, and methods of improving a rejection related symptom by transplanting porcine cells, tissues or organs to a subject in need thereof.

公开(公告)号：US11981928B2

公开(公告)日：2024-05-14

申请号：US16633744

申请日：2018-09-28

申请人： SDF BioPharma Inc.

发明人： Gerald F. Swiss ,  David Kiewlich

IPC分类号： C12N5/071 ,  A61K35/17 ,  A61K35/39 ,  A61P3/10 ,  C07K14/52 ,  C12N5/0781 ,  C12N5/0783

CPC分类号： C12N5/0676 ,  A61K35/17 ,  A61K35/39 ,  A61P3/10 ,  C07K14/522 ,  C12N5/0635 ,  C12N5/0638 ,  C12N5/0646 ,  C12N5/0686 ,  C12N2501/998 ,  C12N2502/11 ,  C12N2502/99 ,  C12N2510/00

摘要： Described herein are human transgenic beta cells expressing fugetactic levels of CXCL12 to a subject in need thereof. Also described herein are beta cells comprising a transgene comprising a nucleic acid sequence encoding CXCL12.

公开(公告)号：US20240148642A1

公开(公告)日：2024-05-09

申请号：US18415877

申请日：2024-01-18

申请人： Vertex Pharmaceuticals Incorporated

发明人： CHRISTOPHER THANOS ,  Danya M. Lavin ,  Briannan E. Bintz ,  Divya Bhatnagar ,  John Mills ,  Megan Billings

IPC分类号： A61K9/00 ,  A61K35/39 ,  A61K47/32 ,  A61K47/34

CPC分类号： A61K9/0024 ,  A61K35/39 ,  A61K47/32 ,  A61K47/34

摘要： The present disclosure provides a cell housing device and a method of manufacturing such a device that has an array of channels to increase the ratio of surface area to volume.

公开(公告)号：US11950995B2

公开(公告)日：2024-04-09

申请号：US18193959

申请日：2023-03-31

申请人： ISLA Technologies, Inc.

发明人： Sara Joan Photiadis ,  Douglas Marc Photiadis ,  Thomas A. Kramer

IPC分类号： A61K9/00 ,  A61F2/02 ,  A61F2/07 ,  A61F2/90 ,  A61K35/39 ,  A61L27/56 ,  A61L31/00 ,  A61L31/08 ,  C12N5/071

CPC分类号： A61F2/022 ,  A61F2/07 ,  A61F2/90 ,  A61K35/39 ,  A61L27/56 ,  A61L31/005 ,  A61L31/08 ,  C12N5/0678 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2240/002 ,  A61F2250/0067 ,  A61L2300/608 ,  A61L2300/64 ,  A61L2420/08 ,  C12N2513/00

摘要： A bioartificial device, such as a bioartificial pancreas, for implantation in a patient's vascular system. The bioartificial pancreas includes a scaffold adapted to engage an interior wall of a blood vessel, a cellular complex support by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising one or more pockets bordered by thin film; and cellular complex comprising pancreatic islets disposed in the one or more pockets, the thin film being adapted to permit oxygen and glucose to diffuse from flowing blood into the one or more pockets at a rate sufficient to support the viability of the islets. The invention also includes methods of making and using a bioartificial pancreas.