公开(公告)号：US20240360421A1

公开(公告)日：2024-10-31

申请号：US18630620

申请日：2024-04-09

申请人： JANSSEN BIOTECH, INC.

发明人： Iqbal S GREWAL ,  Rajkumar GANESAN ,  Sanjaya SINGH

IPC分类号： C12N5/074 ,  A61K35/545 ,  C12N15/86

CPC分类号： C12N5/0696 ,  A61K35/545 ,  C12N15/86 ,  C12N2501/2315 ,  C12N2501/999 ,  C12N2502/1114

摘要： Provided here in are methods of producing induced pluripotent stem cells (iPSCs) and isolated population of produced induced pluripotent stem cells (iPSCs). Also provided herein are methods of treating a subject in need thereof using the produced iPSCs or pharmaceutical compositions comprising the produced iPSCs.

公开(公告)号：US20240352426A1

公开(公告)日：2024-10-24

申请号：US18686708

申请日：2022-08-25

申请人： Vanderbilt University ,  The United States as Represented by The Department of Veterans Affairs

发明人： Lauren E. WOODARD ,  Julie BEJOY

IPC分类号： C12N5/071 ,  A61K35/545

CPC分类号： C12N5/0686 ,  A61K35/545 ,  C12N2500/38 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/165 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2501/91 ,  C12N2506/45 ,  C12N2533/52

摘要： Disclosed herein is a method for producing intermediate mesodermal cells from human pluripotent stem cells. Also disclosed is a method for producing nephron progenitor cells from human pluripotent stem cells. Also disclosed is a method for producing podocytes. Also disclosed is a method for treating a kidney disease in a subject, that involves administering to the subject a therapeutically effective amount of the produced intermediate mesodermal cells, nephron progenitor cells, and/or podocytes.

公开(公告)号：US20240316117A1

公开(公告)日：2024-09-26

申请号：US18734602

申请日：2024-06-05

申请人： Koji TANABE ,  I Peace, Inc.

发明人： Koji TANABE ,  Kenta SUTO

IPC分类号： A61K35/545 ,  A61K8/98 ,  A61P17/14 ,  A61Q19/08

CPC分类号： A61K35/545 ,  A61K8/982 ,  A61P17/14 ,  A61Q19/08

摘要： Provided are a pharmaceutical composition or a pharmaceutical composition raw material, which contains supernatant from a culture medium used during culture to induce pluripotent stem cells.

公开(公告)号：US12097220B2

公开(公告)日：2024-09-24

申请号：US17691778

申请日：2022-03-10

申请人： R&D Systems, Inc.

发明人： David Largaespada ,  Branden Moriarity ,  Beau Webber ,  Neil Otto ,  Sandeep Kumar ,  Leah Hogdal

IPC分类号： A61K35/17 ,  A61K35/545 ,  A61K38/00 ,  A61P35/00 ,  C07K14/705 ,  C12N9/12 ,  C12N9/22 ,  C12N15/63

CPC分类号： A61K35/17 ,  A61K35/545 ,  A61P35/00 ,  C07K14/70503 ,  C12N9/1241 ,  C12N9/22 ,  C12N15/63 ,  A61K38/00

摘要： This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.

公开(公告)号：US20240238239A1

公开(公告)日：2024-07-18

申请号：US18471936

申请日：2023-09-21

申请人： Ojai Energetics PBC

发明人： William KLEIDON

IPC分类号： A61K31/352 ,  A61K9/00 ,  A61K9/48 ,  A61K9/51 ,  A61K31/05 ,  A61K35/28 ,  A61K35/50 ,  A61K35/545 ,  A61K45/06 ,  A61P17/02 ,  A61P25/28 ,  A61P35/00 ,  C12N5/0735 ,  C12N5/074

CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0073 ,  A61K9/4833 ,  A61K9/51 ,  A61K9/5107 ,  A61K31/05 ,  A61K35/28 ,  A61K35/50 ,  A61K35/545 ,  A61K45/06 ,  A61P17/02 ,  A61P25/28 ,  A61P35/00 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/76 ,  C12N2501/999

摘要： The present disclosure relates to cannabinoid compositions used in combination with stem cell therapies. These compositions can be encapsulated (e.g., microencapsulated). In particular, these compositions can be administered to a subject, such as through oral consumption or topical treatment.

公开(公告)号：US20240218325A1

公开(公告)日：2024-07-04

申请号：US18450896

申请日：2023-08-16

申请人： New York Medical College

发明人： Paul LUCAS ,  Jessica C. BLACK

IPC分类号： C12N5/074 ,  A61K35/545

CPC分类号： C12N5/0607 ,  A61K35/545

摘要： The present invention relates to biomarkers, methods, and compositions for characterizing and isolating multipotent adult stem cells (MASCs) and uses thereof.

公开(公告)号：US12023356B2

公开(公告)日：2024-07-02

申请号：US15734210

申请日：2019-07-03

申请人： Masanori Saeki

发明人： Masanori Saeki

IPC分类号： A61K35/28 ,  A61K35/35 ,  A61K35/545

CPC分类号： A61K35/28 ,  A61K35/35 ,  A61K35/545

摘要： Provided is a stem cell filtrate preparation useful for hair regeneration, alleviation of pain caused by a disease of an interosseous joint, such as osteoarthrosis or rheumatoid arthritis, and treatment of the disease, and in addition, restoration of a damaged muscle, and prevention or treatment of decubitus. The stem cell filtrate preparation according to one aspect of the present invention is characterized by including a filtrate of a stem cell from which a cell membrane is removed. The stem cell may be at least one selected from at least one selected from an adipose-tissue-derived mesenchymal stem cell, an epithelial stem cell, a pigmented stem cell, an iPS cell, and an ES cell. Furthermore, the stem cell filtrate preparation includes an adipocyte or an effective component extracted from cellular fat.

公开(公告)号：US20240180972A1

公开(公告)日：2024-06-06

申请号：US18553157

申请日：2022-04-01

申请人： The Regents of the University of California

发明人： Irina M. Conboy ,  Daehwan Kim ,  Michael J. Conboy

IPC分类号： A61K35/545 ,  A61K9/00 ,  A61K31/727 ,  A61K38/17 ,  A61P25/28

CPC分类号： A61K35/545 ,  A61K9/0024 ,  A61K31/727 ,  A61K38/1709 ,  A61P25/28

摘要： In various embodiments, neuroprotective compositions and uses thereof are provided. In certain embodiments, a method of protecting mammalian neurons from neurotoxins, oxidative stress or protein aggregation, mitochondrial dysfunction, inflammatory gene expression, induced cell death is provided where the method involves contacting the cells, such as neurons, with an effective amount of: a plurality of proteins that are secreted by induced pluripotent stem cells (iPSCs) derived from a healthy mammal and/or from a mammal with a disease, such as neurodegenerative pathology, exemplified by amyotrophic lateral sclerosis (ALS) where said proteins are secreted when said iPSC cells are pluripotent; and/or biologically active fragments of said proteins; and/or biologically active analogs of said proteins.

公开(公告)号：US20240173355A1

公开(公告)日：2024-05-30

申请号：US18551975

申请日：2022-04-05

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Mara Pavel-Dinu ,  Matthew H. Porteus

IPC分类号： A61K35/28 ,  A61K35/545 ,  A61P37/04 ,  C12N5/074 ,  C12N5/0789 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

CPC分类号： A61K35/28 ,  A61K35/545 ,  A61P37/04 ,  C12N5/0647 ,  C12N5/0696 ,  C12N9/22 ,  C12N15/111 ,  C12N15/86 ,  C12N2310/20 ,  C12N2750/14143

摘要： The present disclosure provides methods and compositions for treating RAG2 deficiencies in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a functional, codon-optimized RAG 2 cDNA at the endogenous RAG2 locus.

公开(公告)号：US11993787B2

公开(公告)日：2024-05-28

申请号：US15770881

申请日：2016-11-16

申请人： University of Georgia Research Foundation, Inc. ,  Aruna Bio, Inc.

发明人： Steven L. Stice ,  Robin Lynn Webb ,  Tracy A. Stice

IPC分类号： A61K35/12 ,  A61K9/51 ,  A61K35/30 ,  A61K35/545 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797 ,  A01N63/00 ,  A01N65/00 ,  A61K9/50 ,  A61P25/28 ,  G01N33/569

CPC分类号： C12N5/0619 ,  A61K9/5176 ,  A61K35/12 ,  A61K35/545 ,  C12N5/0622 ,  C12N5/0623 ,  A61K9/5068 ,  A61K35/30 ,  A61P25/28 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2533/30 ,  G01N33/56966

摘要： Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.