公开(公告)号：US20250066489A1

公开(公告)日：2025-02-27

申请号：US18949107

申请日：2024-11-15

Applicant: Mersana Therapeutics, Inc.

Inventor： Natalya D. BODYAK ,  Michael J. DEVIT ,  Eric M. KRAULAND ,  Timothy B. LOWINGER ,  Peter U. PARK ,  Bianka PRINZ ,  Aleksandr V. YURKOVETSKIY

IPC: C07K16/28 ,  A61K38/08 ,  A61K39/00 ,  A61K45/06 ,  A61K47/68 ,  C07K16/30 ,  C07K16/32

Abstract: This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.

公开(公告)号：US20250034209A1

公开(公告)日：2025-01-30

申请号：US18915533

申请日：2024-10-15

Applicant: Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Meredith Hay ,  John Konhilas ,  Robin L. Polt ,  Evan Jones ,  Lajos Szabo

IPC: C07K7/14 ,  A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  C07K7/06 ,  C07K9/00

Abstract: The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.

公开(公告)号：US12209142B2

公开(公告)日：2025-01-28

申请号：US17336276

申请日：2021-06-01

Applicant: Institute for Systems Biology ,  The United States of America as Represented by The Secretary of the Army

Inventor： James R. Heath ,  Matthew Idso ,  Alexander J. Winton ,  Matthew B. Coppock ,  Sanchao Liu

IPC: A61K38/07 ,  A61K38/08 ,  A61K47/55 ,  A61K47/64 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08 ,  A61K38/00

Abstract: Disclosed are compounds, compositions, and methods relating to epitope-targeted immunostimulants (EPIs), which comprise a synthetic peptide ligand and an antibody-recruiting moiety. The peptide ligand binds an epitope on a target and the antibody-recruiting moiety recruits antibodies to the target when the EPI is bound to the epitope on the target. Also disclosed are compositions comprising any of the disclosed EPIs. Also disclosed are methods of stimulating an immune reaction to a microorganism or other pathogen in a subject where an EPI is administered to the subject. Also disclosed are methods of identifying the peptide ligand by using multi-omic analysis.

公开(公告)号：US20250017954A1

公开(公告)日：2025-01-16

申请号：US18710370

申请日：2022-11-18

Applicant: Kindra Corporation

Inventor： Hasti Fay Nazemzadeh ,  Sundeep Singh Gill

IPC: A61K31/728 ,  A61K9/00 ,  A61K31/198 ,  A61K31/205 ,  A61K31/355 ,  A61K31/455 ,  A61K36/889 ,  A61K38/08 ,  A61K45/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K47/36 ,  A61K47/44 ,  A61P15/00

Abstract: The present disclosure relates to aqueous topical formulations comprising at least one TRPV1 antagonist and at least one specific plant extract. Also disclosed herein are methods of treating at least one symptom of menopause comprising topically administering an effective amount of the formulations disclosed.

公开(公告)号：US20250011363A1

公开(公告)日：2025-01-09

申请号：US18292696

申请日：2022-07-27

Applicant: SKINMED CO., LTD.

Inventor： Sung Hyun KIM ,  Jin Ho BANG ,  Jeung Hoon LEE ,  Min Ho LEE ,  Yong Chul SHIN ,  Won Il CHOI

IPC: C07K7/06 ,  A61K8/64 ,  A61K38/08 ,  A61Q19/08

Abstract: The present disclosure relates to an optimized shortened peptide that binds to an acetylcholine receptor, and a use thereof. It is expected that it is possible to develop a cosmetic composition for alleviating wrinkles, pharmaceuticals for preventing or treating acetylcholine receptor-related diseases, and health functional foods for improvement of the acetylcholine receptor-related diseases, by using the optimized shortened peptide of the present disclosure, which is shorter than conventional acetylcholine receptor inhibitory peptides but has a high acetylcholine receptor binding force and an acetylcholine receptor inhibitory effect.

公开(公告)号：US12186420B2

公开(公告)日：2025-01-07

申请号：US18464024

申请日：2023-09-08

Applicant: Quthero, Inc. ,  UTI Limited Partnership

Inventor： Serena Mandla ,  Jeffrey Alan Biernaskie ,  Holly Danielle Sparks ,  William Michael Scott ,  Milica Radisic

IPC: A61K38/08 ,  A61K8/64 ,  A61K9/00 ,  A61P17/02 ,  A61Q19/08 ,  C07K7/08 ,  A61Q19/00

Abstract: Compositions, formulations and methods of use thereof for treating, preventing and improving the condition and aesthetic appearance of skin are described. Compositions, formulations and methods of use thereof for treatment of dermis wounds, aged dermis, diseased dermis or damaged dermis are also described. The present compositions and formulations comprise a peptide with an amino acid sequence of QHREDGS (SEQ ID NO: 1) and methods of use thereof.

公开(公告)号：US20250000932A1

公开(公告)日：2025-01-02

申请号：US18761250

申请日：2024-07-01

Applicant: University Of Maryland, Baltimore

Inventor： Michael MCCURDY ,  Jonathan CHOW ,  Maniraj Jeyaraju

IPC: A61K38/08 ,  A61P9/02 ,  C12Q1/37 ,  G01N33/74

Abstract: Angiotensin II therapy has been found to increase mean arterial pressure in patients with catecholamine-resistant vasodilatory shock. Secondary analysis of the dataset from the Angiotensin II for the Treatment of High-Output Shock 3 (ATHOS-3) Study demonstrates that serum renin concentration is markedly elevated in some patients with catecholamine-resistant vasodilatory shock. This Invention relates to a method for identifying a subset of patients with elevated serum renin levels who gain a survival advantage when treated with angiotensin II. The invention therefore provides a method for diagnosis and treatment of catecholamine-resistant vasodilatory shock.

公开(公告)号：US20250000931A1

公开(公告)日：2025-01-02

申请号：US18707072

申请日：2022-10-20

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： June Sun KIM ,  Min Ji KWON ,  Hea Yeon YOO

IPC: A61K38/08 ,  A61P25/04 ,  A61P29/00

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating pain, comprising GR82334 as an active ingredient. Particularly, the present invention relates to: a pharmaceutical composition for preventing or treating pain, comprising GR82334 as an active ingredient; and a pain treatment method comprising a step of intra-articularly or intrathecally administering the pharmaceutical composition of the present invention to an individual in which pain arises.

公开(公告)号：US12178840B2

公开(公告)日：2024-12-31

申请号：US17486432

申请日：2021-09-27

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Annette Khaled ,  Jesus Manuel Perez ,  Rania Bassiouni

IPC: A61K38/10 ,  A61K9/14 ,  A61K38/08 ,  C12Q1/02

Abstract: Disclosed herein are compositions comprising a CT20 peptide and methods of using the disclosed compositions to treat cancers expressing chaperonin containing TCP (CCT).

公开(公告)号：US20240424054A1

公开(公告)日：2024-12-26

申请号：US18823192

申请日：2024-09-03

Applicant: Gal Markel

Inventor： Gal Markel

IPC: A61K38/08 ,  A23L3/34 ,  A23L3/3526 ,  A23L33/135 ,  A23L33/195 ,  C07K7/06

Abstract: Prophylactic and/or therapeutic antipathogen agents are provided that disrupt or prevent the formation of at least one homotypic and/or heterotypic protein-protein interaction that has at least one CEA-family protein and that is involved in the establishment and colonization of a pathogen in a suitable host.