公开(公告)号：US20240358825A1

公开(公告)日：2024-10-31

申请号：US18406869

申请日：2024-01-08

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Ramasamy Mannar Mannan ,  Richard Lee Krebs ,  James Richard Thompson ,  Tedd Alan Childers ,  Mary Kathryn Olsen ,  Robert John Yancey, Jr. ,  Risini Dhammika Weeratna ,  Shucheng Zhang ,  Cedo Martin Bagi

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  A61K39/02 ,  A61K39/108 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/13034 ,  C12N2740/13051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/24334 ,  C12N2770/24351 ,  Y02A50/30

摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

公开(公告)号：US12076392B2

公开(公告)日：2024-09-03

申请号：US17698205

申请日：2022-03-18

申请人： Intervet Inc.

发明人： Ian Tarpey

IPC分类号： C12N7/00 ,  A61K39/21 ,  A61P31/14 ,  C12N15/11 ,  C12N15/33 ,  C12N15/48 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61P31/14 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2740/13034 ,  C12N2740/13071 ,  C12N2770/36143

摘要： The present invention provides a vaccine for feline leukemia virus and methods of making and using the vaccine alone, or in combinations with other protective agents.

公开(公告)号：US12070495B2

公开(公告)日：2024-08-27

申请号：US17439198

申请日：2020-03-13

申请人： ModernaTX, Inc. ,  The United States of America, as represented by the Department of Health and Human Services

发明人： Paolo Lusso ,  Peng Zhang ,  Elisabeth Narayanan ,  Sayda Mahgoub Elbashir

IPC分类号： A61K39/21 ,  A61K39/39 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/6018

摘要： Provided herein are methods and compositions for inducing in a subject abroad neutralizing antibody response to human immunodeficiency virus (HIV) infection.

公开(公告)号：US20240269265A1

公开(公告)日：2024-08-15

申请号：US18567621

申请日：2022-06-09

申请人： CHIMERON BIO CORPORATION

发明人： Jolly Mazumdar Chendrimada ,  Thimmaiah Ponnappa Chendrimada

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61K39/145 ,  A61K39/205 ,  A61K39/21 ,  A61P31/14 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61K39/145 ,  A61K39/205 ,  A61K39/21 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5258 ,  A61K2039/575 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2770/20052 ,  C12N2770/20071

摘要： Provided herein are peptide VLP vaccines that deliver at least one immunogenic antigen to a subject and induce a protective immune response in the subject. Additionally, provided are related methods and compositions.

公开(公告)号：US12053520B2

公开(公告)日：2024-08-06

申请号：US17587817

申请日：2022-01-28

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Xuejun Chen ,  Jeffrey Boyington ,  Hongying Duan Holdsworth ,  Cheng Cheng ,  John R. Mascola

IPC分类号： A61K39/21 ,  C07K14/005 ,  C07K14/16 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/21 ,  C07K14/005 ,  C07K14/162 ,  C12N7/00 ,  C12Y205/01078 ,  A61K2039/5258 ,  A61K2039/55555 ,  C07K2319/00 ,  C12N2740/16023 ,  C12N2740/16043 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171

摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US12053519B2

公开(公告)日：2024-08-06

申请号：US17277694

申请日：2019-09-23

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Kwong ,  Li Ou ,  John Mascola ,  Baoshan Zhang ,  Kai Xu ,  Wing-Pui Kong ,  Yaroslav Tsybovsky ,  Cara W. Chao ,  Jeffrey Boyington ,  Yiran Wang

IPC分类号： A61K39/21 ,  A61K9/16 ,  A61K39/00 ,  A61K39/12 ,  A61K47/64 ,  A61K47/69 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K9/1658 ,  A61K47/64 ,  A61K47/644 ,  A61K47/646 ,  A61K47/6925 ,  A61P31/18 ,  A61K2039/6031 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6075 ,  A61K2039/6081 ,  A61K2039/645

摘要： Embodiments of immunogenic conjugates including the HIV-1 Env fusion peptide and methods of their use and production are disclosed. In several embodiments, the immunogenic conjugates can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US20240238407A1

公开(公告)日：2024-07-18

申请号：US18562059

申请日：2022-05-18

申请人： NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION ,  UNIVERSITY OF THE RYUKYUS ,  DAIICHI SANKYO COMPANY, LIMITED

发明人： Ken ISHII ,  Takuya FUKUSHIMA ,  Yuetsu TANAKA ,  Fumihiko TAKESHITA ,  Makoto KOIZUMI ,  Takako NIWA ,  Shoko NOGUSA ,  Nao JONAI ,  Yoshikuni ONODERA

IPC分类号： A61K39/21 ,  A61K9/51 ,  A61P31/14 ,  A61P37/04 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61K9/5123 ,  A61P31/14 ,  A61P37/04 ,  A61K2039/6018

摘要： Provided is a vaccine for preventing and/or treating infection with human T-cell leukemia virus type 1 (HTLV-1).
A lipid particle encapsulating a nucleic acid expressing a gp46 antigen or a Tax antigen of human T-cell leukemia virus type 1 (HTLV-1), wherein the lipid comprises a cationic lipid represented by general formula (Ia):




or a pharmaceutically acceptable salt thereof,
wherein
R1 and R2 each independently represent a C1-C3 alkyl group;
L1 represents a C17-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups;
L2 represents a C10-C19 alkyl group optionally having one or more C2-C4 alkanoyloxy groups, or a C10-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups; and
p is 3 or 4.

公开(公告)号：US20240156958A1

公开(公告)日：2024-05-16

申请号：US18499765

申请日：2023-11-01

申请人： Design-Zyme LLC

发明人： Peter Albert Petillo ,  Dwight O'Dell Deay, III ,  Mary Beth Carter

IPC分类号： A61K39/39 ,  A61K39/018 ,  A61K39/02 ,  A61K39/145 ,  A61K39/21

CPC分类号： A61K39/39 ,  A61K39/018 ,  A61K39/0208 ,  A61K39/145 ,  A61K39/21 ,  A61K2039/55555

摘要： The present invention is broadly concerned with a vaccine composition comprising a central carrier, at least one linear carbohydrate molecule, and at least one immunogen molecule, wherein each of the at least one linear carbohydrate molecule and at least one immunogen molecule are covalently bound to the carrier via respective covalent linkages. Vaccine compositions comprising multivalent carriers and related methods may find various therapeutic and prophylactic applications for inducing an immune response against, treating, or preventing a bacterial, viral, fungal, or protozoan infection, including, but are not limited to, coronaviruses, Lyme Disease, Chlamydia, and the related diseases thereof.

公开(公告)号：US20240156945A1

公开(公告)日：2024-05-16

申请号：US18282423

申请日：2022-03-17

申请人： Joseph COTROPIA ,  Gaurav CHANDRA

发明人： Joseph COTROPIA ,  Gaurav CHANDRA

IPC分类号： A61K39/21 ,  A61K39/00 ,  C07K14/005 ,  C07K16/10 ,  C12Q1/70 ,  G01N33/569

CPC分类号： A61K39/21 ,  C07K14/005 ,  C07K16/1063 ,  C12Q1/703 ,  G01N33/56988 ,  A61K2039/505 ,  C12N2740/16034 ,  G01N2333/162

摘要： Provided are highly conserved antigens and epitopes of HIV that can be used in vaccines and to produce bindings proteins (e.g., antibodies) for detecting, treating, preventing, or reducing the risk of HIV infection and the development of AIDS.

公开(公告)号：US20240132578A1

公开(公告)日：2024-04-25

申请号：US18452002

申请日：2023-08-18

申请人： INTERNATIONAL AIDS VACCINE INITIATIVE, INC. ,  THE SCRIPPS RESEARCH INSTITUTE ,  THERACLONE SCIENCES INC.

发明人： Po-Ying Chan-Hui ,  Katherine Doores ,  Michael Huber ,  Stephen Kaminsky ,  Steven Frey ,  Ole Olsen ,  Jennifer Mitcham ,  Matthew Moyle ,  Sanjay K. Phogat ,  Dennis R. Burton ,  Laura Majorie Walker ,  Pascal Raymond Georges Poignard ,  Wayne Koff ,  Melissa Danielle De Jean De St. Marcel Simek-Lemos

IPC分类号： C07K16/10 ,  A61K39/21

CPC分类号： C07K16/1063 ,  A61K39/21 ,  C07K16/1045 ,  A61K2039/505

摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.