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    Methods for detection of antibiotic resistant
    8.
    发明授权
    Methods for detection of antibiotic resistant 有权

    公开(公告)号：US11708616B2

    公开(公告)日：2023-07-25

    申请号：US16764765

    申请日：2018-11-16

    申请人： AMERICAN MOLECULAR LABORATORIES INC.

    发明人： Hongjun Zhang ,  Yi Zhou ,  Rajarao Kakuturu

    IPC分类号： C12Q1/68 ,  A61K39/40 ,  C12Q1/689

    CPC分类号： C12Q1/689 ,  A61K39/40 ,  C12Q2600/156

    摘要： The present disclosure provides methods and materials for determining if antibiotic resistant H. pylori is present in a sample. The methods may comprise obtaining a threshold level of H. pylori DNA from the sample, amplifying a region of the H. pylori DNA to generate multiple copies of the region of the H. pylori DNA, sequencing the multiple copies of the region of the H. pylori DNA, comparing sequences of multiple copies of the region of the H. pylori DNA to a reference sequence, identifying the presence of a mutation in multiple copies of the region of the H. pylori DNA, and determining a number of the multiple copies of the region of the H. pylori DNA with the mutation, wherein antibiotic resistant H. pylori is present in the sample when the number of the multiple copies of the region of the H. pylori DNA with the mutation is above a predetermined amount.

    CLOSTRIDIUM DIFFICILE ANTIGENS
    9.
    发明公开
    CLOSTRIDIUM DIFFICILE ANTIGENS 审中-公开

    公开(公告)号：US20230165949A1

    公开(公告)日：2023-06-01

    申请号：US17821730

    申请日：2022-08-23

    申请人： Secretary of State for Health and Social Care ,  MicroPharm Limited

    发明人： Clifford Shone ,  April Roberts ,  Helen Ahern ,  Michael Maynard-Smith ,  John Landon

    IPC分类号： A61K39/08 ,  C07K14/33 ,  C07K16/12 ,  A61K38/16 ,  A61K39/40

    CPC分类号： A61K39/08 ,  C07K14/33 ,  C07K16/1282 ,  A61K38/164 ,  A61K39/40 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2039/505

    摘要： The present application relates to recombinant Clostridium difficile antigens based on a fusion protein that consists of or comprises a first amino acid sequence and a second amino acid sequence, wherein: a) the first amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of residues 1500-1850 of a C. difficile Toxin A sequence or residues 1500-1851 of a C. difficile Toxin B sequence; and b) the second amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of a long repeat unit located within amino acid residues 1851-2710 of a C. difficile Toxin A sequence or within amino acid residues 1852-2366 of a C. difficile Toxin B sequence; though with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543-2710 of a C. difficile Toxin A and with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543-2366 of a C. difficile Toxin B. Also provided is the use of said antigens for the prevention/treatment/suppression of Clostridium difficile infection (CDI), together with methods for generating said antigens, methods for generating antibodies that bind to said antigens, and the use of said antibodies for the prevention/treatment/suppression of CDI.