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    NANOROBOT DESIGN, FUNCTION, AND FABRICATION PROCESS
    4.
    发明申请
    NANOROBOT DESIGN, FUNCTION, AND FABRICATION PROCESS 有权

    公开(公告)号：US20250041420A1

    公开(公告)日：2025-02-06

    申请号：US18793823

    申请日：2024-08-04

    Applicant: Andrew Robert Haverly

    Inventor： Andrew Robert Haverly

    IPC: A61K41/00 ,  A61K9/00 ,  B82Y15/00 ,  G01N27/414

    Abstract: The present invention is a system of nanorobots comprising; a fabrication method, a power generator; electrically controlled proteins; sensors; a method of killing an organism's cells; and a method of communicating with the nanorobots with an outside device; wherein a nanorobot is fabricated, put into the organism, powered, uses sensors to determine whether to kill the organism's cells, selectively kills the organism's cells, the nanorobots can communicate with an outside device, and the nanorobots can release drugs.

    MAGNETIC NANO-DRUG WITH DOUBLE TARGETING VEGF-VEGFR, AND PREPARATION METHOD AND APPLICATION THEREOF
    7.
    发明申请
    MAGNETIC NANO-DRUG WITH DOUBLE TARGETING VEGF-VEGFR, AND PREPARATION METHOD AND APPLICATION THEREOF 有权

    公开(公告)号：US20250017920A1

    公开(公告)日：2025-01-16

    申请号：US18765361

    申请日：2024-07-08

    Applicant: The Third Clinical Medical College, Nanjing University of Chinese Medicine

    Inventor： Xin LIU ,  Ran KANG ,  Lin XIE ,  Congyang XUE ,  Bo CHEN ,  Zihan WANG ,  Nan WANG ,  Liping CHEN

    IPC: A61K31/4965 ,  A61K9/51 ,  A61K38/44 ,  A61K41/00 ,  A61K47/60 ,  A61K47/69

    Abstract: The present disclosure provides a magnetic nano-drug with double targeting vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR), and a preparation method and application thereof, and belongs to the technical field of biomedicine. The magnetic nano-drug of the present disclosure includes aminated ZnFe2O4 hollow porous magnetic nano-particles, lactate dehydrogenase-silk fibroin (LDH-SF), ethylene dichloride (EDC), and n-hydroxy succinimide (NHS). A mass ratio of the aminated ZnFe2O4 hollow porous magnetic nano-particles to the EDC to the NHS to the LDH-SF is (5-10):(1-5):(1-6):(1-8). The magnetic nano-drug according to the present disclosure can position a VEGF ligand through magnetic targeting of hollow zinc ferrite particles, use magnetic particles to regulate reprogramming of macrophages in an intervertebral disc so as to indirectly regulate down-regulation of the VEGF, and inhibit angiogenesis. Meanwhile, the VEGFR is targeted through ligustrazine, controlled release of magnetic heat is combined, and an inhibitory function is achieved. Therefore, double targeting of the magnetic nano-drug can effectively inhibit vascularization, block neurotrophic supply, and implement radical treatment of pain.

    Water irradiated with electromagnetic energies for use as a medicament
    8.
    发明授权
    Water irradiated with electromagnetic energies for use as a medicament 有权

    公开(公告)号：US12194097B2

    公开(公告)日：2025-01-14

    申请号：US17053807

    申请日：2019-05-07

    Applicant: LWP Life Water Prevention SRL

    Inventor： Luigi Camisasca

    IPC: C02F1/30 ,  A61K33/00 ,  A61K33/14 ,  A61K41/00 ,  A61P25/00 ,  A61P25/04

    Abstract: The present invention relates to water for use as a medicament, characterized in that to the water, electromagnetic energies in the form of: (i) light energy with a wavelength of between 500 and 700 nm, (ii) light energy with a wavelength of between 701 and 1050 nm, and (iii) an electrical energy with a maximum voltage of 240 V, are simultaneously applied, wherein at least one of the electromagnetic energies (i), (ii) and (iii) is applied to the water in the form of trains of pulses having at least two discrete frequencies, wherein a first frequency is between 0.1 to 10 Hz and a second frequency is between 40 and 1500 Hz.

    Application of dipyrrinato-iridium complexes in anti-tumor and anti-bacterial therapy
    10.
    发明授权
    Application of dipyrrinato-iridium complexes in anti-tumor and anti-bacterial therapy 有权

    公开(公告)号：US12187749B2

    公开(公告)日：2025-01-07

    申请号：US18162205

    申请日：2023-01-31

    Applicant: BIOLITEC UNTERGEHMENSBETEILIGUNGS II AG

    Inventor： Benjamin Florian Hohlfeld ,  Arno Wiehe ,  Burkhard Gitter ,  Dorika Steen ,  Gerhard Wieland ,  Volker Albrecht

    IPC: C07F15/00 ,  A61K41/00 ,  A61K47/54 ,  A61P31/04 ,  A61P35/00 ,  C07F17/02

    Abstract: Biologically active compounds and their methods of preparation are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, otorhinolaryngology disorders, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Embodiments also include methods to synthesize iridium(III) complex structures incorporating a substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetratfluorophenyldipyrrin) unit or a substituted 3-nitrophenyl-dipyrromethene (3-nitrophenyl-dipyrrin) unit. Amphiphilic compounds with increased anti-tumour and anti-bacterial efficacy are also provided. Specifically, this is achieved by substitution with bromine atoms and sugar moieties.

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