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公开(公告)号:US07183302B2
公开(公告)日:2007-02-27
申请号:US10637099
申请日:2003-08-08
申请人: Jeffrey Lee Romine , Scott W. Martin , Lawrence B. Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse , Julie Lemm , Donald O'Boyle , Min Gao , Richard Colonno
发明人: Jeffrey Lee Romine , Scott W. Martin , Lawrence B. Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse , Julie Lemm , Donald O'Boyle , Min Gao , Richard Colonno
IPC分类号: A61K43/78 , C07D277/18
CPC分类号: C07D417/04 , A61K31/00 , A61K31/426 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , A61K45/06 , C07D277/42 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要: Compounds having the structure of formula I are described wherein R, R′, R1, R2, and R3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular the function of the HCV NS5A protein.
摘要翻译: 描述了具有式I结构的化合物,其中R 1,R 2,R 1,R 2和R 3均如 规范。 该化合物可以抑制丙型肝炎病毒(HCV)复制,特别是HCV NS5A蛋白的功能。
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2.Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative 失效
标题翻译: 包含止泻剂和埃坡霉素或埃坡霉素衍生物的组合公开(公告)号:US07030147B2
公开(公告)日:2006-04-18
申请号:US10471904
申请日:2002-03-18
IPC分类号: A61K43/78 , A61K31/425 , A61K43/00 , A61K31/33 , A61K43/02
CPC分类号: A61K45/06 , Y10S514/867 , Y10S514/974
摘要: Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
摘要翻译: 与治疗增殖性疾病的抗腹泻剂(例如DPP-IV抑制剂)共同施用埃博霉素衍生物。
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