公开(公告)号：US20250064754A1

公开(公告)日：2025-02-27

申请号：US18941163

申请日：2024-11-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US12226399B2

公开(公告)日：2025-02-18

申请号：US17826289

申请日：2022-05-27

Applicant: SK BIOPHARMACEUTICALS CO., LTD.

Inventor： Pravada Pendse ,  Murali M Bommana ,  Regina H. Noh ,  Augustin Pegan ,  Travis John Webb ,  Jejuan Maxwell

IPC: A61K31/41 ,  A61K9/10 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61P25/00

Abstract: The present disclosure relates to an aqueous formulation comprising as an active ingredient a carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof, poloxamer, and an aqueous carrier, wherein the aqueous formulation is in the form of a suspension formulation.

公开(公告)号：US12225905B2

公开(公告)日：2025-02-18

申请号：US18212471

申请日：2023-06-21

Applicant: Matoke Holdings Limited

Inventor： Thomas Hall ,  Sophie Constance Cox ,  Liam Michael Grover ,  David Kershaw

IPC: A61K9/06 ,  A01N59/00 ,  A01N63/50 ,  A61K38/36 ,  A61K38/44 ,  A61K38/48 ,  A61K47/26 ,  A61K47/32 ,  A61K47/40 ,  A61L26/00

Abstract: A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.

公开(公告)号：US20250051262A1

公开(公告)日：2025-02-13

申请号：US18930738

申请日：2024-10-29

Applicant: Biothea Pharma, Inc.

Inventor： Jean-Pierre Sommadossi ,  Adel Moussa

IPC: C07C215/60 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38

Abstract: Described herein are epinephrine salts, specifically the epinephrine malonate salt; the epinephrine malonate salt in crystalline form; a pharmaceutical composition comprising epinephrine malonate; a sublingual or buccal pharmaceutical composition comprising epinephrine malonate in crystalline form; and a method for treating a patient comprising administering a pharmaceutical composition of epinephrine malonate in crystalline form.

公开(公告)号：US20250049721A1

公开(公告)日：2025-02-13

申请号：US18931464

申请日：2024-10-30

Applicant: Astellas Pharma Inc. ,  Medivation Prostate Therapeutics LLC

Inventor： Douglas Alan Lorenz ,  Sanjay Konagurthu ,  Randy J. Wald ,  Jason A. Everett ,  Sheila Matz ,  Yuuki Takaishi ,  Toshiro Sakai ,  Ryousuke Irie ,  Shinsuke Oba ,  Hiroyasu Toyota ,  Koji Nishimura ,  Atsushi Kanbayashi

IPC: A61K9/20 ,  A61K9/10 ,  A61K9/16 ,  A61K31/4164 ,  A61K31/4166 ,  A61K47/32 ,  A61K47/38 ,  C07D233/86

Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.

公开(公告)号：US20250041372A1

公开(公告)日：2025-02-06

申请号：US18776013

申请日：2024-07-17

Applicant: UIF (University Industry Foundation), Yonsei University

Inventor： Yong SHIN ,  Zhen QIAO

IPC: A61K36/537 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61P17/02 ,  A61P31/04

Abstract: Proposed is a pharmaceutical composition for antibacterial wound healing, the pharmaceutical composition including chia seeds and biodegradable substances. The pharmaceutical composition may be customized depending on the wound and may also be prepared in a transparent form. The pharmaceutical composition exhibits unique self-adhesive properties, so the pharmaceutical composition may be directly attached to the skin and withstand joint movement through excellent deformation adaptability and has high tensile strength. The pharmaceutical composition also has an antibacterial effect and an excellent wound-healing effect.

公开(公告)号：US20250041253A1

公开(公告)日：2025-02-06

申请号：US18926688

申请日：2024-10-25

Applicant: Florida State University Research Foundation, Inc.

Inventor： Eric HOLMES ,  Gary OSTRANDER

IPC: A61K31/167 ,  A61K9/00 ,  A61K9/28 ,  A61K9/48 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/38 ,  A61K47/40

Abstract: The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

公开(公告)号：US12214084B2

公开(公告)日：2025-02-04

申请号：US16628742

申请日：2018-07-11

Applicant: QUALICAPS CO., LTD.

Inventor： Yoshiro Osaki ,  Makoto Aso ,  Toshimitsu Usui ,  Mamoru Honda

IPC: A61K9/48 ,  A61K9/00 ,  A61K47/32 ,  A61K47/38

Abstract: An object of the present disclosure is providing a hard capsule made of a hard capsule film having enteric properties that can be molded by a cold gel method. An enteric hard capsule comprises a film containing a first component and a second component, and further containing at least one component selected from the group consisting of a third component, a fourth component, and a fifth component, wherein the first component is a nonionic water-soluble cellulose compound having a viscosity value within a range of from 100 mPa·s to 100,000 mPa·s, the second component is an enteric methacrylic acid copolymer, the third component is an enteric cellulose compound, wherein the fourth component is a water-insoluble (meth)acrylic acid alkyl ester copolymer, and the fifth component is at least one kind selected from the group consisting of polyvinyl alcohol, a plasticizer, and a surfactant.

公开(公告)号：US20250032406A1

公开(公告)日：2025-01-30

申请号：US18915901

申请日：2024-10-15

Applicant: Savannah Johnson ,  Ronald K. Hutchens ,  David Neil McClanahan ,  Pankaj Patel ,  Travis O'Neal ,  Dwayne William Beeson ,  Wesley Steven Jones

Inventor： Savannah Johnson ,  Ronald K. Hutchens ,  David Neil McClanahan ,  Pankaj Patel ,  Travis O'Neal ,  Dwayne William Beeson ,  Wesley Steven Jones

IPC: A61K9/00 ,  A24B13/00 ,  A24B15/28 ,  A61K45/06 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

Abstract: The disclosure provides oral products, the oral products including a fleece material that includes fibers and a releasable component. In some embodiments, oral products as described herein may be in the form of a pouchless product including a fleece material having a releasable component associated therewith, or in the form of a pouched product including a fleece material having a releasable component associated therewith in the form of a pouch, containing a substrate material therein.

公开(公告)号：US12208169B2

公开(公告)日：2025-01-28

申请号：US18054816

申请日：2022-11-11

Applicant: CELISTA PHARMACEUTICALS LLC

Inventor： Yogesh Dandiker ,  Maulik K. Panchal

IPC: A61K9/70 ,  A61K31/568 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61M35/00 ,  A61M39/22

Abstract: The invention relates to a sprayable liquid solution for the transdermal delivery of testosterone comprising testosterone, a penetration enhancer, and a film forming excipient, and to methods of treatment using this composition.